{"id":96413,"date":"2023-11-14T06:40:00","date_gmt":"2023-11-13T22:40:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=96413"},"modified":"2023-11-14T06:40:00","modified_gmt":"2023-11-13T22:40:00","slug":"%e9%a8%b0%e7%9b%9b%e5%8d%9a%e8%97%a5%e5%9c%a82023%e5%b9%b4%e7%be%8e%e5%9c%8b%e8%82%9d%e7%97%85%e7%a0%94%e7%a9%b6%e5%8d%94%e6%9c%83%e5%b9%b4%e6%9c%83%ef%bc%88aasld%ef%bc%89%e4%b8%8a%e7%99%bc%e4%bd%88","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=96413","title":{"rendered":"\u9a30\u76db\u535a\u85e5\u57282023\u5e74\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5354\u6703\u5e74\u6703\uff08AASLD\uff09\u4e0a\u767c\u4f48\u6700\u65b0\u6578\u64da\uff0c\u5f37\u8abf\u5728\u5be6\u73feHBV\u529f\u80fd\u6027\u6cbb\u7652\u65b9\u9762\u7684\u9032\u5c55"},"content":{"rendered":"<div>\n<div>\n<table name=\"logo_release\" border=\"0\" cellspacing=\"10\" cellpadding=\"5\" align=\"right\">\n<tbody>\n<tr>\n<td><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><i>\u76f4\u63a5\u8b49\u64da\u986f\u793a\uff0c<\/i><i>BRII-179\u8a98\u5c0e\u7684\u529f\u80fd\u6027\u6297\u9ad4\u61c9\u7b54\u6709\u52a9\u65bc\u63d0\u9ad8\u548c\u7dad\u6301HBsAg\u6e05\u9664\u7387<\/i><\/p>\n<p><i>\u5728\u5229\u7528<\/i><i>BRII-179\u5bcc\u96c6\u5177\u6709\u5167\u5728\u9ad4\u6db2\u514d\u75ab\u61c9\u7b54\u7684\u60a3\u8005\u4ee5\u63d0\u9ad8HBsAg\u6e05\u9664\u7387\u6216HBV\u529f\u80fd\u6027\u6cbb\u7652\u7387\u65b9\u9762\u7372\u5f97\u65b0\u7684\u6d1e\u5bdf<\/i><\/p>\n<p><i>\u65b0\u6578\u64da\u652f\u6301\u9032\u5165\u5f8c\u671f\u81e8\u5e8a\u958b\u767c\u968e\u6bb5\uff0c\u9019\u4e9b\u6578\u64da\u6709\u671b\u70ba\u6162\u6027\u4e59\u578b\u809d\u708e\u7684\u6cbb\u7652\u6027\u7642\u6cd5\u63d0\u4f9b\u4f9d\u64da<\/i><\/p>\n<p>\u5317\u4eac\u7f8e\u570b\u548c\u5317\u5361\u7f85\u4f86\u7d0d\u5dde\u9054\u52d2\u59c62023\u5e7411\u670814\u65e5 \/\u7f8e\u901a\u793e\/ \u2014\u00a0<a href=\"https:\/\/www.briibio.com\/cn\/\" target=\"_blank\" rel=\"nofollow noopener\">\u9a30\u76db\u535a\u85e5\u751f\u7269\u79d1\u6280\u6709\u9650\u516c\u53f8<\/a>\uff08\u300c\u9a30\u76db\u535a\u85e5\u300d\u6216\u300c\u516c\u53f8\u300d\uff0c\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u91dd\u5c0d\u60a3\u8005\u672a\u88ab\u6eff\u8db3\u7684\u9700\u6c42\u4ee5\u53ca\u91cd\u5927\u516c\u5171\u885b\u751f\u6027\u75be\u75c5\u958b\u767c\u5275\u65b0\u7642\u6cd5\u7684\u8de8\u570b\u4f01\u696d\uff0c\u4eca\u65e5\u5728\u99ac\u85a9\u8af8\u585e\u5dde\u6ce2\u58eb\u9813\u8209\u884c\u7684\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5354\u6703\u5e74\u6703\uff08AASLD\uff09\u4e0a\u5206\u4eab\u4e86\u4e09\u5f35\u58c1\u5831\uff0c\u5176\u4e2d\u5169\u5f35\u58c1\u5831\u70ba\u6700\u65b0\u7a81\u7834\u58c1\u5831\uff0c\u63d0\u4f9b\u4e86\u6162\u6027\u4e59\u578b\u809d\u708e\uff08CHB\uff09\u81e8\u5e8a\u9805\u76ee\u4e2d\u7684\u5169\u9805\u8655\u65bc2\u671f\u7814\u767c\u968e\u6bb5\u7684\u7522\u54c1BRII-179\uff08VBI-2601\uff09\u548cBRII-835\uff08VIR-2218\uff09\u7684\u6700\u65b0\u6578\u64da\u3002<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder1\">\n<\/div>\n<p>\u9a30\u76db\u535a\u85e5\u9996\u5e2d\u91ab\u5b78\u5b98David Margolis\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u5f88\u9ad8\u8208\u80fd\u5728\u809d\u75c5\u5e74\u6703\u4e0a\u5206\u4eab\u9019\u4e9b\u6578\u64da\u3002\u9019\u4e9b\u6578\u64da\u8b49\u5be6\u6211\u5011HBV\u7ba1\u7dda\u7d44\u5408\u7684\u591a\u529f\u80fd\u6027\uff0c\u4e26\u5c55\u793a\u4e86\u6211\u5011\u5728\u5c0b\u627eHBV\u529f\u80fd\u6027\u6cbb\u7652\u65b9\u6cd5\u904e\u7a0b\u4e2d\u7684\u91cd\u8981\u6d1e\u898b\u3002HBsAg\u6e05\u9664\u8207\u6297\u9ad4\u61c9\u7b54\u4e4b\u9593\u7684\u91cd\u8981\u806f\u7e6b\uff0c\u70ba\u9032\u4e00\u6b65\u63d0\u9ad8\u529f\u80fd\u6027\u6cbb\u7652\u7387\u548c\u8b58\u5225\u6700\u6709\u53ef\u80fd\u5c0d\u6cbb\u7652\u6027\u7642\u6cd5\u7522\u751f\u61c9\u7b54\u7684\u60a3\u8005\u6307\u660e\u4e86\u65b9\u5411\u3002\u6211\u5011\u7684\u76ee\u6a19\u662f\u5728\u76e1\u53ef\u80fd\u5ee3\u6cdb\u7684\u4eba\u7fa4\u4e2d\u70ba\u5408\u9069\u7684\u60a3\u8005\u958b\u767c\u9069\u7576\u7684\u6cbb\u7642\u65b9\u6848\uff0c\u540c\u6642\u8b93\u60a3\u8005\u907f\u514d\u9078\u64c7\u6602\u8cb4\u6216\u8010\u53d7\u6027\u8f03\u5dee\u4e14\u4e0d\u6703\u7d66\u4ed6\u5011\u5e36\u4f86\u7372\u76ca\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n<p>\u5728\u6700\u65b0<a href=\"https:\/\/www.briibio.com\/media\/pjzdkb2t\/1-aasld-poster-brii-179-002.pdf\" target=\"_blank\" rel=\"nofollow noopener\">\u7a81\u7834\u58c1\u5831\u5831\u544a<\/a>\u4e2d\uff0c\u9a30\u76db\u535a\u85e5\u516c\u4f48\u4e86BRII-179\u806f\u5408\u805a\u4e59\u4e8c\u9187\u5e72\u64fe\u7d20\u03b1\uff08PEG-IFN\u03b1\uff09\u6cbb\u7642CHB\u60a3\u8005\u7684\u96a8\u6a5f\u3001\u5b89\u6170\u5291\u5c0d\u7167\u548c\u96d9\u76f2\u76842\u671f\u7814\u7a76\u6cbb\u7642\u7d44\u5225\u5c64\u9762\u63ed\u76f2\u7684\u9032\u4e00\u6b65\u6578\u64da\u3002\u5831\u544a\u7d50\u679c\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5728\u73fe\u6709PEG-IFN\u03b1\u6cbb\u7642\u57fa\u790e\u4e0a\u806f\u5408BRII-179\u7e3d\u9ad4\u4e0a\u5b89\u5168\u4e14\u8010\u53d7\u6027\u826f\u597d\uff0c\u5176\u4e0d\u826f\u4e8b\u4ef6\u8207\u65e2\u5f80\u5831\u9053\u7684PEG-IFN\u03b1\u6cbb\u7642\u548cBRII-179\u7684\u4e0d\u826f\u4e8b\u4ef6\u76f8\u4f3c\u3002<\/li>\n<li>\u5728\u7b2c36\u5468\uff08\u6cbb\u7642\u7d50\u675f\u5f8c [EOT] 12\u5468\uff09\uff0c\u8207\u5b89\u6170\u5291 + PEG-IFN\u03b1\u7d44\u76f8\u6bd4\uff0cBRII-179 + PEG-IFN\u03b1\u7d44\u7684HBsAg\u6e05\u9664\u7387\u66f4\u9ad8\uff08\u5168\u5206\u6790\u96c6 [FAS]\uff1a24.6% vs. 14.0%\uff0c\u7b26\u5408\u65b9\u6848\u96c6 [PPS]\uff1a31.8% vs. 14.9%\uff09\u3002\u5728\u7b2c24\u5468\uff08EOT\uff09\u5df2\u89c0\u5bdf\u5230\u8a72HBsAg\u6e05\u9664\u7387\u65b9\u9762\u7684\u5dee\u7570\uff0c\u9019\u7a2e\u5dee\u7570\u4e00\u76f4\u7dad\u6301\u5230\u7b2c36\u5468\u3002\u81e8\u5e8a\u7814\u7a76\u9084\u767c\u73fe\uff0c\u5728\u7b2c24\u5468\uff08EOT\uff09\uff0c\u806f\u5408\u7d66\u85e5\u7d44\u7684HBsAg\u8840\u6e05\u5b78\u8f49\u63db\u7387\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291 + PEG-IFN\u03b1\u7d44\uff08FAS\uff1a15.8% vs. 1.8%\uff0c<i>p=0.0163<\/i>\uff1bPPS\uff1a19.6% vs. 2.0%\uff0c<i>p=0.0058<\/i>\uff09\u3002<\/li>\n<li>\u806f\u5408BRII-179\u53ef\u8a98\u5c0e\u91dd\u5c0dHBsAg\u7684\u7a69\u5065\u7684\u3001\u529f\u80fd\u6027\u7684\u6297\u9ad4\u61c9\u7b54\u3002BRII-179 + PEG-IFN\u03b1\u806f\u5408\u7d66\u85e5\u7d44\u7684\u53d7\u8a66\u8005\u5728\u7b2c24\u5468\u548c\u7b2c36\u5468\u7684\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u9ad4\uff08HBsAb\uff09\u61c9\u7b54\u7387\u986f\u8457\u9ad8\u65bc\u5b89\u6170\u5291 + PEG-IFN\u03b1\u7d44\uff08\u7b2c24\u5468FAS\uff1a38.6% vs. 14.0%\uff0c<i>p=0.0052<\/i>\uff1bPPS\uff1a39.1% vs. 13.7%\uff0c<i>p=0.0054<\/i>\uff1b\u7b2c36\u5468FAS\uff1a33.3% vs. 12.3%\uff0c<i>p=0.0131<\/i>\uff1bPPS\uff1a34.1% vs. 10.6%\uff0c<i>p=0.0105<\/i>\uff09\u3002\u5728\u7b2c24\u5468\u548c\u7b2c36\u5468\uff0cHBsAb\u6ef4\u5ea6\u8207HBsAg\u6e05\u9664\u986f\u8457\u76f8\u95dc\uff0cHBsAg\u53cd\u5f48\u76845\u4f8b\u60a3\u8005\u4e2d\u67094\u4f8b\u6aa2\u6e2c\u4e0d\u5230\u6297\u9ad4\u61c9\u7b54\u3002<\/li>\n<li>\u9019\u9805\u6982\u5ff5\u9a57\u8b49\u6027\u7814\u7a76\u7684\u6578\u64da\u8868\u660e\uff0c\u806f\u5408BRII-179\u53ef\u8a98\u5c0e\u529f\u80fd\u6027\u514d\u75ab\u61c9\u7b54\uff0c\u63d0\u9ad8\u63a5\u53d7PEG-IFN\u03b1\u6cbb\u7642\u7684CHB\u60a3\u8005\u7684HBsAg\u6e05\u9664\u7387\u548c\u6e05\u9664\u6301\u7e8c\u6642\u9593\uff0c\u9032\u800c\u63d0\u9ad8CHB\u529f\u80fd\u6027\u6cbb\u7652\u7387\u3002<\/li>\n<\/ul>\n<p>\u5728\u7b2c\u4e8c\u5f35\u6700\u65b0<a href=\"https:\/\/www.briibio.com\/media\/qrlnl304\/2-aasld-poster-brii-179-835-001.pdf\" target=\"_blank\" rel=\"nofollow noopener\">\u7a81\u7834\u58c1\u5831\u5831\u544a<\/a>\u4e2d\uff0c\u9a30\u76db\u535a\u85e5\u5c55\u793a\u4e86BRII-179-001\u548cBRII-179-835-001\u7814\u7a76\u7684\u8f49\u5316\u7814\u7a76\u6578\u64da\uff0c\u8868\u660e\u50c5\u5728\u90e8\u5206CHB\u53d7\u8a66\u8005\u4e2d\u89c0\u5bdf\u5230BRII-179\u53ef\u8a98\u5c0e\u7368\u7279\u7684HBsAg\u6297\u9ad4\u61c9\u7b54\uff0c\u9019\u8aaa\u660e\u4e00\u4e9b\u60a3\u8005\u5c0dHBV\u7684\u5167\u5728\u514d\u75ab\u61c9\u7b54\u53ef\u80fd\u53d7\u5230\u4e86\u66f4\u56b4\u91cd\u7684\u640d\u5bb3\u3002\u6b64\u5916\uff0c\u7814\u7a76\u4eba\u54e1\u9084\u767c\u73fe\uff1a<\/p>\n<ul type=\"disc\">\n<li>BRII-179\u806f\u5408BRII-835\uff08VIR-2218\uff09\u6bcf\u6708\u4e00\u6b21\u7d66\u85e5\uff0c\u9023\u7e8c\u7d66\u85e59\u500b\u6708\u7684\u8010\u53d7\u6027\u7e3d\u9ad4\u826f\u597d\uff0c\u6c92\u6709\u767c\u751f2\u7d1a\u4ee5\u4e0a\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u3002<\/li>\n<li>\u5728\u63a5\u53d7\u6838\u7518\uff08\u9178\uff09\u9006\u8f49\u9304\u9176\u6291\u5236\u5291\uff08NrtI\uff09\u6cbb\u7642\u7684CHB\u53d7\u8a66\u8005\u4e2d\uff0cBRII-179\u55ae\u85e5\u6cbb\u7642\u6216\u806f\u5408BRII-835\u6cbb\u7642\u5747\u53ef\u8a98\u5c0e\u7522\u751f\u986f\u8457\u7684HBV\u7279\u7570\u6027T\u7d30\u80de\u61c9\u7b54\uff0c\u800c\u50c5\u5728\u90e8\u5206CHB\u53d7\u8a66\u8005\u4e2d\uff0c\u5728\u8207BRII-835\u806f\u5408\u63a5\u7a2e9\u5291\u5f8c\uff08\u4e00\u7a2eHBV\u9776\u5411siRNA\uff0c\u53ef\u964d\u4f4e\u514d\u75ab\u6291\u5236\u6027\u75c5\u6bd2\u6297\u539f\u5982HBsAg\uff09\uff0c\u5f15\u8d77\u986f\u8457\u7684\u6297HBsAg\u6297\u9ad4\u61c9\u7b54\u3002<\/li>\n<li>\u514d\u75ab\u5206\u6790\u8868\u660e\uff0cBRII-179\u53ef\u4ee5\u63d0\u4f9b\u4e00\u500b\u7368\u7279\u7684\u6a5f\u6703\uff0c\u53ef\u4ee5\u5bcc\u96c6\u80fd\u5920\u7522\u751f\u5fc5\u8981\u7684\u6297HBsAg\u6297\u9ad4\u61c9\u7b54\u7684CHB\u60a3\u8005\uff0c\u5728\u4e00\u4e9b\u60a3\u8005\u4e2d\u5be6\u73fe\u66f4\u9ad8\u7684\u529f\u80fd\u6027\u6cbb\u7652\u7387\uff0c\u540c\u6642\u907f\u514d\u5176\u4ed6\u60a3\u8005\u63a5\u53d7\u4e0d\u5fc5\u8981\u7684\u6cbb\u7642\u3002<\/li>\n<\/ul>\n<p>\u5728\u53e6\u4e00\u500b<a href=\"https:\/\/www.briibio.com\/media\/iyshdux0\/3-aasld-poster-vir-2218-pk.pdf\" target=\"_blank\" rel=\"nofollow noopener\">\u58c1\u5831\u5831\u544a<\/a>\u4e2d\uff0c\u9a30\u76db\u535a\u85e5\u91cd\u9ede\u4ecb\u7d39\u4e861b\/2\u671f\u548c2\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2dBRII-835\uff08VIR-2218\uff09\u5728\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u4e2d\u7684\u591a\u6b21\u7d66\u85e5\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\uff0c\u4ee5\u53ca\u5340\u57df\u6216\u7a2e\u65cf\u80cc\u666f\u53ef\u80fd\u5c0d\u85e5\u7269PK\u7522\u751f\u7684\u5f71\u97ff\u3002\u91cd\u9ede\u5167\u5bb9\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>BRII-835\u5728\u6162\u6027HBV\u611f\u67d3\u60a3\u8005\u4e2d\u7684PK\u7279\u6027\u8207\u5728\u5065\u5eb7\u5fd7\u9858\u8005\u4e2d\u7684PK\u7279\u6027\u57fa\u672c\u76f8\u4f3c\u3002\u5291\u91cf\u70ba50 mg\u548c100 mg\u6642\uff0c\u89c0\u5bdf\u5230\u5168\u8eab\u66b4\u9732\u91cf\u5448\u5291\u91cf\u4f9d\u8cf4\u6027\u589e\u52a0\u3002\u56db\u5468\u5f8c\u7b2c2\u6b21\u7d66\u85e5\u5f8c\uff0c\u8840\u6f3f\u4e2d\u7121\u660e\u986f\u84c4\u7a4d\u3002<\/li>\n<li>\u4e9e\u592a\u5730\u5340\u548c\u4e2d\u570b\u5927\u9678\u5165\u7d44\u60a3\u8005\u7684PK\u7279\u5fb5\u76f8\u4f3c\uff0c\u8868\u660e\u4f86\u81ea\u4e2d\u570b\u5927\u9678\u7684\u4e2d\u570b\u60a3\u8005\u7684\u7a2e\u65cf\u80cc\u666f\u672a\u7522\u751f\u986f\u8457\u5f71\u97ff\uff0c\u9019\u53ef\u4ee5\u652f\u6301\u4e2d\u570b\u5927\u9678\u53c3\u8207\u672a\u4f86\u5168\u7403\u8a66\u9a57\uff0c\u4ee5\u9032\u4e00\u6b65\u8a55\u4f30BRII-835\u3002<\/li>\n<\/ul>\n<p>\u4f5c\u70ba\u9a30\u76db\u535a\u85e5\u958b\u767cHBV\u529f\u80fd\u6027\u6cbb\u7652\u7368\u7279\u65b9\u6cd5\u7684\u4e00\u90e8\u5206\uff0c\u516c\u53f8\u8207\u5176\u5408\u4f5c\u5925\u4f34\u6b63\u5728\u9032\u884c\u591a\u9805\u81e8\u5e8a2\u671f\u7814\u7a76\uff0c\u5305\u62ecBRII-835\u548cBRII-179\u806f\u5408\u7528\u85e5\u3001BRII-179\u548cPEG-IFN\u237a\u806f\u5408\u7528\u85e5\u3001BRII-835\u3001BRII-877\uff08VIR-3434\uff09\u806f\u5408\u6216\u4e0d\u806f\u5408PEG-IFN\u237a\u3002\u6b64\u5916\uff0cVir Biotechnology, Inc.\uff08\u300cVir\u300d\uff09\u9084\u5728\u7814\u7a76VIR-2218\u548c\/\u6216VIR-3434\u7528\u65bc\u6cbb\u7642HBV\/HDV\u5408\u4f75\u611f\u67d3\u3002<\/p>\n<p><b>\u95dc\u65bc\u4e59\u578b\u809d\u708e<br \/><\/b>\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u662f\u4e16\u754c\u4e0a\u6700\u91cd\u5927\u7684\u611f\u67d3\u6027\u75be\u75c5\u5a01\u8105\u4e4b\u4e00\uff0c\u5168\u7403\u611f\u67d3\u4eba\u6578\u8d85\u904e2.9\u5104\u3002<sup>1<\/sup>\u6162\u6027HBV\u611f\u67d3\u662f\u809d\u81df\u75be\u75c5\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u6bcf\u5e74\u7d04\u670982\u842c\u4eba\u6b7b\u65bc\u6162\u6027HBV\u611f\u67d3\u7684\u4f75\u767c\u75c7\u3002<sup>1<\/sup>\u4e2d\u570b\u6162\u6027HBV\u611f\u67d3\u4eba\u6578\u90548,700\u842c\uff0c\u975e\u5e38\u503c\u5f97\u95dc\u6ce8\u3002<sup>2<\/sup><\/p>\n<p><b>\u95dc\u65bc<\/b><b>BRII-179<br \/><\/b>BRII-179\uff08VBI-2601\uff09\u662f\u4e00\u7a2e\u57fa\u65bc\u91cd\u7d44\u86cb\u767d\u8cea\u7684\u65b0\u578bHBV \u514d\u75ab\u6cbb\u7642\u5019\u9078\u85e5\u7269\uff0c\u53ef\u8868\u9054Pre-S1\u3001Pre-S2\u548cS HBV\u8868\u9762\u6297\u539f\uff0c\u65e8\u5728\u8a98\u5c0e\u589e\u5f37\u548c\u5ee3\u6cdb\u7684B\u7d30\u80de\u548cT\u7d30\u80de\u514d\u75ab\u61c9\u7b54\u3002\u4f5c\u70ba\u6cbb\u7642\u6162\u6027HBV\u611f\u67d3\u7684\u6f5b\u5728\u529f\u80fd\u6027\u6cbb\u7652\u65b9\u6848\u7684\u4e00\u90e8\u5206\uff0c\u9a30\u76db\u535a\u85e5\u6b63\u5728\u958b\u5c55BRII-179\u8207BRII-835\uff08VIR-2218\uff09\u806f\u5408\u7528\u85e5\uff0c\u53caBRII-179\u8207PEG-IFN\u03b1\u806f\u5408\u7528\u85e5\u7684\u5169\u98052\u671f\u7814\u7a76\u3002<\/p>\n<p>\u9a30\u76db\u535a\u85e5\u65bc2018\u5e7412\u6708\u5f9eVBI Vaccines, Inc.\uff08\u300cVBI\u300d\uff09\u5f15\u9032\u4e86BRII-179\uff0c\u7372\u5f97\u4e86\u5728\u5305\u62ec\u4e2d\u570b\u5927\u9678\uff0c\u9999\u6e2f\uff0c\u6fb3\u9580\u548c\u53f0\u7063\u5730\u5340\u7684\u5546\u696d\u5316\u6b0a\u76ca\u3002\u516c\u53f8\u9084\u81ea2023\u5e747\u6708\u8d77\uff0c\u5c07BRII-179\u7684\u7368\u5bb6\u8a31\u53ef\u64f4\u5c55\u81f3\u5168\u7403\u5e02\u5834\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>BRII-835<br \/><\/b>BRII-835\uff08VIR-2218\uff09\u662f\u4e00\u7a2e\u7d93\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5\u7684\u9776\u5411HBV\u7684siRNA\u7814\u7a76\u6027\u85e5\u7269\uff0c\u5177\u6709\u5c0dHBV\u76f4\u63a5\u6297\u75c5\u6bd2\u6d3b\u6027\u548c\u8a98\u5c0e\u6709\u6548\u514d\u75ab\u61c9\u7b54\u7684\u6f5b\u529b\u3002\u5b83\u662f\u9996\u500b\u9032\u5165\u81e8\u5e8a\u7684\u63a1\u7528\u589e\u5f37\u578b\u7a69\u5b9a\u5316\u5b78+\uff08ESC+\uff09\u6280\u8853\u7684siRNA\uff0c\u53ef\u589e\u5f37\u7a69\u5b9a\u6027\u4e26\u6700\u5927\u7a0b\u5ea6\u5730\u964d\u4f4e\u812b\u9776\u6548\u61c9\uff0c\u5f9e\u800c\u53ef\u63d0\u5347\u6cbb\u7642\u6548\u529b\u3002\u9a30\u76db\u535a\u85e5\u65bc2020\u5e74\u5f9eVir Biotechnology, Inc.\uff08\u300cVir\u300d\uff09\u7372\u5f97\u4e86\u5728\u5927\u4e2d\u83ef\u5730\u5340\u958b\u767c\u548c\u5546\u696d\u5316BRII-835\u7684\u5c08\u6709\u6b0a\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b> BRII-877<br \/><\/b>BRII-877\uff08VIR-3434\uff09\u662f\u4e00\u7a2e\u76ae\u4e0b\u6ce8\u5c04\u7684\u7814\u7a76\u6027HBV\u4e2d\u548c\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u65e8\u5728\u963b\u65b7\u6240\u670910\u7a2e\u57fa\u56e0\u578b\u7684HBV\u9032\u5165\u809d\u7d30\u80de\uff0c\u4e26\u964d\u4f4e\u8840\u6db2\u4e2d\u75c5\u6bd2\u9846\u7c92\u548c\u4e9e\u75c5\u6bd2\u9846\u7c92\u7684\u6c34\u5e73\u3002BRII-877\uff08VIR-3434\uff09\u7d50\u5408\u4e86Xencor\u7684Xtend <img decoding=\"async\" src=\"https:\/\/s.w.org\/images\/core\/emoji\/14.0.0\/72x72\/2122.png\" alt=\"\u2122\" class=\"wp-smiley\" style=\"height: 1em; max-height: 1em;\">\u548c\u5176\u4ed6Fc\u6280\u8853\uff0c\u901a\u904e\u9019\u4e9b\u6539\u9020\u6709\u5e0c\u671b\u5728\u611f\u67d3\u60a3\u8005\u4e2d\u4f5c\u70ba\u91dd\u5c0dHBV\u7684T\u7d30\u80de\u75ab\u82d7\uff0c\u4e26\u5177\u6709\u5ef6\u9577\u7684\u534a\u8870\u671f\u3002\u9a30\u76db\u535a\u85e5\u65bc2022\u5e74\u5f9eVir Biotechnology, Inc.\uff08\u201dVir\u201d\uff09\u7372\u5f97\u4e86BRII-877\u5728\u5927\u4e2d\u83ef\u5340\u7684\u7368\u5bb6\u958b\u767c\u548c\u5546\u696d\u5316\u6b0a\u76ca\u3002<\/p>\n<p><b>\u95dc\u65bc\u9a30\u76db\u535a\u85e5<br \/><\/b>\u9a30\u76db\u535a\u85e5\uff08\u80a1\u7968\u4ee3\u78bc\uff1a2137.HK\uff09\u662f\u4e00\u5bb6\u5546\u696d\u5316\u968e\u6bb5\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u81f4\u529b\u65bc\u91dd\u5c0d\u5b58\u5728\u5de8\u5927\u672a\u88ab\u6eff\u8db3\u7684\u60a3\u8005\u9700\u6c42\u3001\u6cbb\u7642\u624b\u6bb5\u6709\u9650\uff0c\u4ee5\u53ca\u7d66\u60a3\u8005\u5e36\u4f86\u56b4\u91cd\u793e\u6703\u6b67\u8996\u7684\u91cd\u5927\u516c\u5171\u885b\u751f\u6311\u6230\u958b\u767c\u5275\u65b0\u7642\u6cd5\u3002\u516c\u53f8\u5c08\u6ce8\u65bc\u611f\u67d3\u6027\u75be\u75c5\u548c\u4e2d\u6a1e\u795e\u7d93\u7cfb\u7d71\u75be\u75c5\uff0c\u6b63\u5728\u63a8\u9032\u4e00\u689d\u6db5\u84cb\u591a\u7a2e\u7368\u7279\u5019\u9078\u85e5\u7269\u7684\u7522\u54c1\u7ba1\u7dda\uff0c\u4e26\u901a\u904e\u9818\u5148\u7684\u9805\u76ee\u958b\u767c\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u7684\u65b0\u578b\u529f\u80fd\u6027\u6cbb\u7652\u65b9\u6848\uff0c\u548c\u91dd\u5c0d\u7522\u5f8c\u6291\u9b31\u75c7\uff08PPD\uff09\u4ee5\u53ca\u91cd\u5ea6\u6291\u9b31\u75c7\uff08MDD\uff09\u7684\u9996\u5275\u6cbb\u7642\u65b9\u6848\u3002\u5728\u5bcc\u6709\u9060\u898b\u5353\u8b58\u548c\u7d93\u9a57\u8c50\u5bcc\u7684\u9818\u5c0e\u5718\u968a\u5e36\u9818\u4e0b\uff0c\u516c\u53f8\u5728\u4f4d\u65bc\u7f85\u5229-\u9054\u52d2\u59c6\u3001\u820a\u91d1\u5c71\u7063\u5340\u3001\u5317\u4eac\u548c\u4e0a\u6d77\u7684\u4e3b\u8981\u751f\u7269\u6280\u8853\u4e2d\u5fc3\u958b\u5c55\u696d\u52d9\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f<a href=\"http:\/\/www.briibio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.briibio.com<\/a>\u3002<\/p>\n<p>\u00a0<\/p>\n<p>1\u00a0World Health Organization. (<span class=\"xn-chron\">June 2022<\/span>). <i>Hepatitis B.<\/i> World Health Organization. Retrieved from <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-b\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/hepatitis-b<\/a><br \/>2\u00a0World Health Organization. <i>Hepatitis.<\/i> World Health Organization. Retrieved from <a href=\"https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C\" target=\"_blank\" rel=\"nofollow noopener\">https:\/\/www.who.int\/china\/health-topics\/hepatitis#:~:text=There%20are%2087%20million%20people,living%20with%20chronic%20hepatitis%20C<\/a>.<\/p>\n<p>\u00a0<\/p>\n<\/div>\n<p>\n\u65b0\u805e\u4f86\u6e90\uff1aPR Newswire<\/p>\n<p>\u4ee5\u4e0a\u65b0\u805e\u6295\u7a3f\u5167\u5bb9\u7531PR Newswire \u7f8e\u901a\u793e\u5168\u6b0a\u81ea\u8ca0\u8cac\u4efb\uff0c\u82e5\u6709\u6d89\u53ca\u4efb\u4f55\u9055\u53cd\u6cd5\u4ee4\u3001\u9055\u53cd\u672c\u7db2\u7ad9\u6703\u54e1\u689d\u6b3e\u3001\u6709\u4fb5\u5bb3\u7b2c\u4e09\u4eba\u6b0a\u76ca\u4e4b\u865e\uff0c\u5c07\u4e00\u6982\u7531PR Newswire \u7f8e\u901a\u793e\u627f\u64d4\u6cd5\u5f8b\u53ca\u640d\u5bb3\u8ce0\u511f\u4e4b\u8cac\u4efb\uff0c\u8207\u65b0\u982d\u689dThehubnews\u7121\u95dc\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u76f4\u63a5\u8b49\u64da\u986f\u793a\uff0cBRII-179\u8a98\u5c0e\u7684\u529f\u80fd\u6027\u6297<\/p>\n","protected":false},"author":6,"featured_media":96414,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[423],"class_list":["post-96413","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-life","tag-423","two-columns"],"_links":{"self":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts\/96413","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=96413"}],"version-history":[{"count":0,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts\/96413\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/media\/96414"}],"wp:attachment":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=96413"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=96413"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=96413"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}