{"id":96398,"date":"2023-11-14T02:00:00","date_gmt":"2023-11-13T18:00:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=96398"},"modified":"2023-11-14T02:00:00","modified_gmt":"2023-11-13T18:00:00","slug":"aasld%e6%9c%80%e6%96%b0%e7%aa%81%e7%a0%b4%e7%a0%94%e7%a9%b6%e7%b5%90%e6%9e%9c%e6%98%9f%e6%bc%a2%e5%be%b7%e7%94%9f%e7%89%a9%e5%85%a8%e7%90%83%e9%a6%96%e5%80%8bhbv%e7%89%b9%e7%95%b0%e6%80%a7%e7%9a%84tc","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=96398","title":{"rendered":"AASLD\u6700\u65b0\u7a81\u7834\u7814\u7a76\u7d50\u679c|\u661f\u6f22\u5fb7\u751f\u7269\u5168\u7403\u9996\u500bHBV\u7279\u7570\u6027\u7684TCR-T\u7d30\u80de\u7642\u6cd5\u5be6\u73fe\u665a\u671f\u809d\u764c\u6709\u6548\u816b\u7624\u61c9\u7b54\u548c\u6301\u4e45\u6297\u75c5\u6bd2\u53cd\u61c9"},"content":{"rendered":"
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\u65b0\u52a0\u57612023\u5e7411\u670814\u65e5 \/\u7f8e\u901a\u793e\/ \u2014 11\u670814\u65e5<\/span>\uff0c\u5728\u7f8e\u570b\u6ce2\u58eb\u9813\u8209\u884c\u7684\u7f8e\u570b\u809d\u75c5\u5354\u6703\u5e74\u6703(AASLD \u2013 The Liver Meeting)\u4e0a<\/span>\uff0c\u661f\u6f22\u5fb7\u751f\u7269\u7684HBV\u7279\u7570\u6027\u7684TCR-T\u7d30\u80de\u7642\u6cd5 \u2013 SCG101\u5165\u9078\u6700\u65b0\u7a81\u7834\uff08Late-breaking\uff09\u81e8\u5e8a\u7814\u7a76\u3002\u8a72\u7814\u7a76\u986f\u793a\uff0cSCG101\u5728\u6cbb\u7642\u665a\u671f\u4e59\u578b\u809d\u708e\u75c5\u6bd2\uff08HBV\uff09\u76f8\u95dc\u809d\u7d30\u80de\u764c\uff08HCC\uff09\u60a3\u8005\u4e2d\u8868\u73fe\u51fa\u986f\u8457\u7684\u6297\u75c5\u6bd2\u548c\u6297\u816b\u7624\u6d3b\u6027\uff0c\u4e26\u986f\u8457\u5ef6\u9577\u4e86\u60a3\u8005\u7684\u7121\u9032\u5c55\u751f\u5b58\u671f\u3002<\/p>\n

\u6839\u64da\u516c\u4f48\u5167\u5bb9\uff0c6\u4f8b\u665a\u671fHBV\u76f8\u95dc\u809d\u764c\u60a3\u8005\u63a5\u53d7\u4e86\u55ae\u6b215.0\u00d7107<\/sup>\uff5e1.0\u00d7108<\/sup>\/kg TCR+ T\u7d30\u80de\u8f38\u6ce8, \u5176\u4e2d2\u4f8b\u60a3\u8005\u9054\u5230\u90e8\u5206\u7de9\u89e3(PR)\u2013\u5176\u4e2d1\u4f8b\u60a3\u8005\u809d\u75c5\u7076\u9054\u5230\u75c5\u7406\u5b8c\u5168\u7de9\u89e3\uff08pCR\uff09\uff0c\u53e6\u59162\u4f8b\u60a3\u8005\u75be\u75c5\u7a69\u5b9a(SD)\u4e26\u89c0\u5bdf\u5230\u816b\u7624\u7e2e\u5c0f\u3002<\/p>\n

\u7814\u7a76\u5206\u6790\u986f\u793a\uff0c\u60a3\u8005\u7684\u816b\u7624\u61c9\u7b54\u8207SCG101\u7684\u6297\u75c5\u6bd2\u6d3b\u6027\u9ad8\u5ea6\u76f8\u95dc\u3002\u7814\u7a76\u4e2d\u5168\u90e8\u60a3\u8005(100%)\u63a5\u53d7SCG01\u6cbb\u7642\u5f8c\u5747\u89c0\u5bdf\u5230\u8840\u6e05HBsAg\u4e0b\u964d\uff0c\u5176\u4e2d\u67094\u4f8b\u60a3\u8005\u66f4\u89c0\u5bdf\u5230 1\uff5e3 log\u7684\u8840\u6e05HBsAg\u986f\u8457\u964d\u4f4e\uff0c\u4e26\u7dad\u6301\u5728\u4f4e\u6c34\u5e73\u9577\u905490\u5468\uff08\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff09\uff0c\u6c92\u6709\u53cd\u5f48\u3002\u540c\u6642\uff0c\u8a724\u4f8b\u60a3\u8005\u5747\u89c0\u5bdf\u5230\u816b\u7624\u7e2e\u5c0f\uff0c\u4e14\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08PFS)\u986f\u8457\u5ef6\u9577\u81f325.8\u5468\uff08\u81f3\u6578\u64da\u622a\u6b62\u65e5\uff09\u3002<\/p>\n

\u5317\u4eac\u5354\u548c\u91ab\u9662\u809d\u81df\u5916\u79d1\u4e3b\u4efb\u675c\u9806\u9054\u4e3b\u4efb\u8868\u793a: \u300c \u4e2d\u570b\u662f\u809d\u764c\u5927\u570b,\u8207\u6b50\u7f8e\u570b\u5bb6\u4e0d\u540c\uff0cHBV\u611f\u67d3\u662f\u6211\u570b\u6700\u4e3b\u8981\u7684\u809d\u764c\u75c5\u56e0\u3002SCG101\u91dd\u5c0dHBV\u76f8\u95dc\u809d\u764c\u7684\u767c\u75c5\u6a5f\u5236\uff0c\u901a\u904e\u7279\u7570\u6027T\u7d30\u80de\uff0c\u9776\u5411HBV\u6297\u539f\uff0c\u5f9e\u6839\u6e90\u4e0a\u70ba\u809d\u764c\u7cbe\u6e96\u91ab\u7642\u5e36\u4f86\u65b0\u7684\u601d\u8def\u548c\u65b9\u5411\uff0c\u521d\u6b65\u7684\u81e8\u5e8a\u6578\u64da\u4e5f\u70ba\u5ee3\u5927\u60a3\u8005\u5e36\u4f86\u4e86\u65b0\u7684\u5e0c\u671b\u3002\u300d\u00a0<\/p>\n

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\u661f\u6f22\u5fb7\u751f\u7269\u9996\u5e2d\u57f7\u884c\u5b98\u738b\u6a39\u7acb\u8868\u793a\uff1a\u300c \u661f\u6f22\u5fb7\u751f\u7269\u81f4\u529b\u65bc\u958b\u767c\u91dd\u5c0d\u75c5\u6bd2\u611f\u67d3\u53ca\u5176\u76f8\u95dc\u764c\u75c7\uff08\u809d\u764c\u3001\u5bae\u9838\u764c\u3001\u9f3b\u54bd\u764c\u7b49\uff09\u7684\u65b0\u578b\u9776\u5411\u514d\u75ab\u7642\u6cd5\u3002\u6211\u5011\u5f88\u9ad8\u8208SCG101\u6210\u70ba\u9996\u6b3e\u9776\u5411\u4e59\u809d\u75c5\u6bd2\u7684TCR-T\u7d30\u80de\u7642\u6cd5\uff0c\u4e26\u5728\u6cbb\u7642\u809d\u764c\u75c5\u4f8b\u5c55\u793a\u51fa\u975e\u5e38\u986f\u8457\u7684\u6297\u816b\u7624\u7642\u6548\u548c\u6301\u4e45\u7684\u6297\u75c5\u6bd2\u53cd\u61c9\uff0c\u70ba\u60a3\u8005\u5e36\u4f86\u4e86\u5de8\u5927\u7372\u76ca\u3002SCG101\u7684\u826f\u597d\u8868\u73fe\u4e5f\u8b93\u6211\u5011\u5c0dSCG\u7368\u5bb6\u64c1\u6709\u3001\u5168\u7403\u9818\u5148\u7684GianTTM<\/sup> TCR\u5275\u65b0\u6280\u8853\u5e73\u53f0\u5145\u6eff\u4fe1\u5fc3\u548c\u66f4\u591a\u671f\u5f85\uff0c\u5fc5\u5c07\u63a8\u52d5\u516c\u53f8\u52a0\u901f\u63a2\u7d22\u958b\u767c\u51fa\u66f4\u591a\u653b\u514b\u5be6\u9ad4\u816b\u7624\u7684TCR-T\u7d30\u80de\u6cbb\u7642\u7522\u54c1\u3002\u300d\u00a0<\/p>\n

\u95dc\u65bc<\/b>SCG101<\/b><\/p>\n

SCG101\u662f\u4e00\u7a2e\u91dd\u5c0d\u4e59\u578b\u809d\u708e\u8868\u9762\u6297\u539f\u7279\u7570\u6027\u7684\u81ea\u9ad4T\u7d30\u80de\u53d7\u9ad4(TCR) T\u7d30\u80de\u7642\u6cd5\u3002\u661f\u6f22\u5fb7\u751f\u7269\u4f9d\u6258\u81ea\u4e3b\u7814\u767c\u7684\u7368\u6709GianTTM<\/sup>\u6280\u8853\u5e73\u53f0\uff0c\u7be9\u9078\u9ad8\u89aa\u529b\u4e14\u9ad8\u6d3b\u6027\u7684\u5929\u7136TCR\uff0c\u53ef\u4ee5\u6709\u6548\u9776\u5411\u5be6\u9ad4\u816b\u7624\u4e2d\u901a\u904e\u4e3b\u8981\u7d44\u7e54\u76f8\u5bb9\u6027\u5fa9\u5408\u9ad4(MHC)\u8868\u9054\u7684\u7d30\u80de\u5167\u6297\u539f\u3002\u81e8\u5e8a\u524d\u548c\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u986f\u793a\uff0cSCG101\u5177\u6709\u816b\u7624\u6291\u5236\u548cHBV cccDNA\u6839\u9664\u4f5c\u7528\uff0c\u53ef\u5be6\u73fe\u6297\u816b\u7624\u548c\u6297\u75c5\u6bd2\u529f\u80fd\u3002SCG101\u5df2\u7372\u7f8e\u570b\u98df\u54c1\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(FDA)\u3001\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40(NMPA)\u3001\u65b0\u52a0\u5761\u885b\u751f\u79d1\u5b78\u7ba1\u7406\u5c40(HSA) \u548c\u9999\u6e2f\u885b\u751f\u7f72\uff08DOH\uff09\u6279\u51c6\u7528\u65bc\u4e59\u809d\u611f\u67d3\u76f8\u95dc\u809d\u764c\u7684\u81e8\u5e8a\u8a66\u9a57\u3002<\/p>\n

\u95dc\u65bc\u809d\u7d30\u80de\u764c<\/b><\/p>\n

\u809d\u7d30\u80de\u764c\u662f\u6700\u5e38\u898b\u7684\u809d\u764c\u985e\u578b\uff0c\u64da\u4f30\u8a08\uff0c\u5168\u7403\u6bcf\u5e74\u6709\u8d85\u904e90\u842c\u4f8b\u809d\u764c\u65b0\u767c\u75c5\u4f8b\uff0c\u70ba\u5168\u7403\u764c\u75c7\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u4e4b\u4e00\u3002\u4e59\u578b\u809d\u708e\u75c5\u6bd2\u611f\u67d3\u662f\u5c0e\u81f4\u809d\u764c\u7684\u4e3b\u8981\u539f\u56e0\uff0c\u5728\u4e2d\u570b\u5360\u809d\u7d30\u80de\u764c\u75c5\u4f8b\u7684\u8d85\u904e80%\u3002\u809d\u764c\u767c\u73fe\u7684\u6642\u5019\u4e00\u822c\u90fd\u662f\u665a\u671f\uff0c\u751f\u5b58\u6642\u9593\u77ed\u3001\u75c5\u6b7b\u7387\u9ad8\uff0c5\u5e74\u751f\u5b58\u7387\u4e0d\u8db315% [2],[3]<\/sup>\u3002<\/p>\n

\u95dc\u65bc<\/b>\u661f\u6f22\u5fb7\u751f\u7269<\/b><\/p>\n

\u661f\u6f22\u5fb7\u751f\u7269\u662f\u4e00\u5bb6\u9818\u5148\u7684\u751f\u7269\u6280\u8853\u516c\u53f8\uff0c\u5c08\u6ce8\u65bc\u958b\u767c\u611f\u67d3\u53ca\u5176\u76f8\u95dc\u764c\u75c7\u7684\u65b0\u578b\u514d\u75ab\u7642\u6cd5\u3002\u516c\u53f8\u91dd\u5c0d\u6700\u5e38\u898b\u7684\u81f4\u764c\u611f\u67d3\uff1a\u5e7d\u9580\u87ba\u687f\u83cc\u3001\u4eba\u4e73\u982d\u7624\u75c5\u6bd2\uff08HPV\uff09\u3001\u4e59\u809d\u75c5\u6bd2\uff08HBV\uff09\u548c\u4eba\u985e\u76b0\u75b9\u75c5\u6bd2\uff08EBV\uff09\u7b49\uff0c\u958b\u767c\u5ee3\u6cdb\u800c\u7368\u7279\u7684TCR-T\u7d30\u80de\u7642\u6cd5\u3001\u96d9\u7279\u7570\u6297\u9ad4\u548c\u6cbb\u7642\u6027\u75ab\u82d7\uff0c\u5be6\u73fe\u9810\u9632\u548c\u6cbb\u7652\u611f\u67d3\u548c\u5176\u76f8\u95dc\u7684\u764c\u75c7\u7684\u76ee\u6a19\u3002\u661f\u6f22\u5fb7\u751f\u7e3d\u90e8\u4f4d\u65bc\u65b0\u52a0\u5761\uff0c\u7d50\u5408\u65b0\u52a0\u5761\u3001\u4e2d\u570b\u548c\u5fb7\u570b\u7684\u5340\u57df\u512a\u52e2\uff0c\u6db5\u84cb\u5f9e\u5275\u65b0\u85e5\u7269\u7814\u767c\u3001\u751f\u7522\u3001\u81e8\u5e8a\u8a66\u9a57\u548c\u5546\u696d\u5316\u7684\u5b8c\u6574\u7522\u696d\u50f9\u503c\u93c8\u3002\u6b32\u77ad\u89e3\u66f4\u591a\u95dc\u65bc\u661f\u6f22\u5fb7\u751f\u7269\uff0c\u8acb\u8a2a\u554f\u6211\u5011\u7684\u7db2\u7ad9www.scgcell.com\u3002<\/p>\n

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[1]\u00a0 \u00a0 \u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u539f\u767c\u6027\u809d\u764c\u8a3a\u7642\u6307\u53572018.V1.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[2]\u00a0 \u00a0 Liver cancer statistics: World cancer research fund international. WCRF International. (2022, April 14).<\/span><\/p>\n<\/td>\n<\/tr>\n

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[3]\u00a0 \u00a0 Golabi P, Fazel S, Otgonsuren M, Sayiner M, Locklear CT, Younossi ZM. (2017). Mortality assessment of patients with hepatocellular carcinoma according to underlying disease and treatment modalities. Medicine (Baltimore). 2017 Mar;96(9):e5904. doi: 10.1097\/MD.0000000000005904. PMID: 28248853; PMCID: PMC5340426.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n

\n\u65b0\u805e\u4f86\u6e90\uff1aPR Newswire<\/p>\n

\u4ee5\u4e0a\u65b0\u805e\u6295\u7a3f\u5167\u5bb9\u7531PR Newswire \u7f8e\u901a\u793e\u5168\u6b0a\u81ea\u8ca0\u8cac\u4efb\uff0c\u82e5\u6709\u6d89\u53ca\u4efb\u4f55\u9055\u53cd\u6cd5\u4ee4\u3001\u9055\u53cd\u672c\u7db2\u7ad9\u6703\u54e1\u689d\u6b3e\u3001\u6709\u4fb5\u5bb3\u7b2c\u4e09\u4eba\u6b0a\u76ca\u4e4b\u865e\uff0c\u5c07\u4e00\u6982\u7531PR Newswire \u7f8e\u901a\u793e\u627f\u64d4\u6cd5\u5f8b\u53ca\u640d\u5bb3\u8ce0\u511f\u4e4b\u8cac\u4efb\uff0c\u8207\u65b0\u982d\u689dThehubnews\u7121\u95dc\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

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