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\u4e2d\u570b\u676d\u5dde\u548c\u7d39\u8208<\/span>2023\u5e7411\u670813\u65e5<\/span> \/\u7f8e\u901a\u793e\/ \u2014 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u4eca\u65e5\u5ba3\u5e03\u57282023\u5e74\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5354\u6703\uff08AASLD\uff09\u5e74\u6703\uff08The Liver Meeting\u00ae<\/sup> 2023\uff09\u4e0a\uff0c\u4ee5\u6700\u65b0\u7a81\u7834\u6458\u8981\u58c1\u5831\u5f62\u5f0f\u5c55\u793aASC22\uff08\u6069\u6c83\u5229\u55ae\u6297\uff09\u7528\u65bc\u6162\u6027\u4e59\u578b\u809d\u708e\uff08\u6162\u6027\u4e59\u809d\uff09\u529f\u80fd\u6027\u6cbb\u6108\u7684IIb\u671f\u64f4\u5c55\u968a\u5217\u671f\u4e2d\u7d50\u679c\uff0c\u4e26\u4ee5\u6458\u8981\u58c1\u5831\u5f62\u5f0f\u5c55\u793aASC41\u6cbb\u7642\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u7684I\u671f\u7814\u7a76\u7d50\u679c\u3002<\/p>\n

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\u58c1\u5831\u7de8\u865f\uff1a5052-C<\/b><\/p>\n

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\u80cc\u666f\uff1a<\/b><\/p>\n

49\u4f8b\u57fa\u7dda\u4e59\u809d\u8868\u9762\u6297\u539f\uff08HBsAg\uff09\u2264100 IU\/mL\u7684\u60a3\u8005\u64f4\u5c55\u968a\u5217\u5df2\u555f\u52d5\uff0c\u65e8\u5728\u63a2\u7d22\u5728\u6b64\u7279\u5b9a\u4eba\u7fa4\u4e2d\u5be6\u73feHBsAg\u6301\u7e8c\u6e05\u9664\u3002<\/p>\n

\u65b9\u6cd5\uff1a<\/b><\/p>\n

ASC22\u64f4\u5c55\u968a\u5217\u5165\u7d44\u4e8649\u4f8b\u57fa\u7ddaHBsAg\u2264100 IU\/mL\u7684\u60a3\u8005\u3002\u60a3\u8005\u63a5\u53d7\u6bcf\u5169\u5468\u4e00\u6b21\uff08Q2W\uff09\u76ae\u4e0b\u8a3b\u5c041.0\u6beb\u514b\/\u516c\u65a4ASC22\uff08ASC22\u968a\u5217\uff0cn=40\uff09\u6216\u5b89\u6170\u5291\uff08n=9\uff09\uff0c\u6bd4\u4f8b\u7d04\u70ba4:1\uff0c\u6cbb\u764224\u5468\uff0c\u6240\u6709\u60a3\u8005\u5747\u63a5\u53d7\u6838\u82f7\uff08\u9178\uff09\u985e\u4f3c\u7269\uff08NAs\uff09\u4f5c\u70ba\u80cc\u666f\u6cbb\u7642\u3002\u6cbb\u7642\u7d50\u675f\u5f8c\uff0c\u518d\u9032\u884c24\u5468\u96a8\u8a2a\u3002\u63a5\u53d7ASC22\u6cbb\u764224\u5468\u5f8c\u5be6\u73feHBsAg\u6e05\u9664\u7684\u60a3\u8005\u9810\u8a08\u5728\u96a8\u8a2a\u968e\u6bb5\u505c\u6b62NAs\u80cc\u666f\u6cbb\u7642\u3002\u4e3b\u8981\u7642\u6548\u7d42\u9ede\u70baHBsAg\u4e0b\u964d\u3002\u671f\u4e2d\u5206\u6790\u5728\u7d0450%\u5165\u7d44\u60a3\u8005\u5b8c\u621024\u5468ASC22\u6216\u5b89\u6170\u5291\u6cbb\u7642\u6642\u9032\u884c\u3002<\/p>\n

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\u58c1\u5831\u5c55\u793a\uff1a<\/b><\/p>\n

\u58c1\u5831\u7de8\u865f: 2401-C<\/b><\/p>\n

\u6a19\u984c\uff1a<\/b><\/p>\n

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\u80cc\u666f\uff1a<\/b><\/p>\n

ASC41\u5728\u7f8e\u570b\u5065\u5eb7\u53d7\u8a66\u8005\u4e2d\u7684\u85e5\u7269-\u85e5\u7269\u76f8\u4e92\u4f5c\u7528\uff08DDI\uff09\u4ee5\u53ca\u5728\u4e2d\u570b\u5065\u5eb7\u53d7\u8a66\u8005\u6216\u7f8e\u570b\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u75c5\uff08NAFLD\uff09\u53d7\u8a66\u8005\u4e2d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u3001\u5b89\u5168\u6027\u548c\u85e5\u6548\u5b78\uff08PD\uff09\u7d50\u679c\u5df2\u767c\u5e03\u3002<\/p>\n

\u65b9\u6cd5\uff1a<\/b><\/p>\n

NCT04527250<\/span><\/a><\/span> \u662f\u4e00\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u55ae\u6b21\u548c\u591a\u6b21\u5291\u91cf\u905e\u589e\u53e3\u670dASC41\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\u548c\u85e5\u6548\u5b78\u3002NCT04845646<\/span><\/a><\/span> \u662f\u4e00\u9805\u958b\u653e\u6a19\u7c3d\u3001DDI\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30\u670d\u75285\u6beb\u514b\u55ae\u5291\u91cf\u7684ASC41\u7247\u5291\u5f8c\uff0c\u4f0a\u66f2\u5eb7\u5511\uff08CYP3A\u5f37\u6291\u88fd\u5291\uff09\u548c\u82ef\u59a5\u82f1\uff08CYP3A\u5f37\u8a98\u5c0e\u5291\uff09\u5c0dASC41\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u5f71\u97ff\u4ee5\u53caASC41\u5728NAFLD\u60a3\u8005\u4e2d\u7684\u85e5\u4ee3\u52d5\u529b\u5b78\u3002<\/p>\n

\u7d50\u8ad6\uff1a<\/b><\/p>\n

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\u300c\u975e\u5e38\u69ae\u5e78\u57282023\u5e74\u7f8e\u570b\u809d\u75c5\u7814\u7a76\u5354\u6703\u5e74\u6703\u4ee5\u6700\u65b0\u7a81\u7834\u6458\u8981\u58c1\u5831\u548c\u6458\u8981\u58c1\u5831\u5206\u5225\u5c55\u793a\u4e86ASC22\u6162\u6027\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108IIb\u64f4\u5c55\u968a\u5217\u7684\u671f\u4e2d\u7d50\u679c\u548cASC41\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u7684I\u671f\u7814\u7a76\u7d50\u679c\uff0c\u9019\u6a19\u8a8c\u8457\u6b4c\u79ae\u5728\u6162\u6027\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u6108\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u9818\u57df\u53d6\u5f97\u4e86\u65b0\u7684\u7a4d\u6975\u9032\u5c55\u3002\u6162\u6027\u4e59\u809d\u548c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u5728\u4e16\u754c\u7bc4\u570d\u5167\u4ecd\u5b58\u5728\u5927\u91cf\u672a\u88ab\u6eff\u8db3\u7684\u91ab\u7642\u9700\u6c42\uff1a\u4e2d\u570b\u7d04\u67098,600\u842c\u4eba\u611f\u67d3\u4e59\u809d\u75c5\u6bd2[1]<\/sup>\uff0c\u5176\u4e2d\u7d04\u670915%~22%\u7684\u60a3\u8005\u4e59\u809d\u8868\u9762\u6297\u539f\u5c0f\u65bc\u7b49\u65bc100 IU\/mL[2][3]<\/sup>\uff1b\u52302030\u5e74\u4e2d\u570b\u9810\u8a08\u7d04\u67094,800\u842c\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u60a3\u8005[4]<\/sup>\uff0c\u76ee\u524d\u5c1a\u7121\u4efb\u4f55\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u85e5\u7269\u7372\u6279\u4e0a\u5e02\u3002\u6211\u5011\u5c07\u52a0\u5feb\u81e8\u5e8a\u7814\u7a76\uff0c\u7e7c\u7e8c\u63d0\u9ad8\u6211\u5011\u5728\u809d\u75c5\u6cbb\u7642\u9818\u57df\u7684\u7af6\u722d\u529b\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u6703\u4e3b\u5e2d\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\u3002<\/p>\n

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[1]Lim J K, Nguyen M H, Kim W R, et al. Prevalence of Chronic Hepatitis B Virus Infection in the United States [J]. The American journal of gastroenterology 2020, 115(9): 1429-38.<\/span><\/p>\n<\/p>\n<\/td>\n<\/tr>\n

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[2]Xie, Y., Li, M., Ou, X. et al. HBeAg-positive patients with HBsAg < 100 IU\/mL and negative HBV RNA have lower risk of virological relapse after nucleos(t)ide analogues cessation. J Gastroenterol 56, 856\u2013867 (2021).\u00a0<\/span><\/p>\n<\/p>\n<\/td>\n<\/tr>\n

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[3]Coffin, Carla S et al. \u300cClinical Outcomes and Quantitative HBV Surface Antigen Levels in Diverse Chronic Hepatitis B Patients in Canada: A Retrospective Real-World Study of CHB in Canada (REVEAL-CANADA).\u300d Viruses vol. 14,12 2668. 29 Nov. 2022<\/span><\/p>\n<\/p>\n<\/td>\n<\/tr>\n

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[4]Estes, Chris et al. \u300cModeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016-2030.\u300d Journal of hepatology vol. 69,4 (2018): 896-904.\u00a0<\/span><\/p>\n<\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u95dc\u65bcAASLD<\/b><\/p>\n

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