{"id":94497,"date":"2023-11-07T09:48:00","date_gmt":"2023-11-07T01:48:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=94497"},"modified":"2023-11-07T09:48:00","modified_gmt":"2023-11-07T01:48:00","slug":"%e9%bd%8a%e9%ad%af%e8%a3%bd%e8%97%a5%e8%89%be%e5%b8%95%e6%b4%9b%e5%88%a9%e5%96%ae%e6%8a%97%ef%bc%88ql1604%ef%bc%89i%e6%9c%9f%e7%a0%94%e7%a9%b6%e7%b5%90%e6%9e%9c%e7%99%bc%e8%a1%a8","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=94497","title":{"rendered":"\u9f4a\u9b6f\u88fd\u85e5\u827e\u5e15\u6d1b\u5229\u55ae\u6297\uff08QL1604\uff09I\u671f\u7814\u7a76\u7d50\u679c\u767c\u8868"},"content":{"rendered":"
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\u6fdf\u5357<\/span>2023\u5e7411\u67086\u65e5<\/span> \/\u7f8e\u901a\u793e\/ \u2014 \u8fd1\u65e5\uff0c\u9f4a\u9b6f\u88fd\u85e5\u827e\u5e15\u6d1b\u5229\u55ae\u6297\uff08\u7814\u767c\u4ee3\u865f\uff1aQL1604\uff09I\u671f\u7814\u7a76\u7d50\u679c\u5728\u7dda\u767c\u8868\u65bc\u5b78\u8853\u671f\u520a\u300a\u514d\u75ab\u5b78\u524d\u6cbf\u300b\u300aFrontiers in Immunology\u300b\uff082022\u5e74\u5f71\u97ff\u56e0\u5b50\uff1a7.3\uff09\u3002\u8ad6\u6587\u984c\u76ee\u70ba\u300a\u8a55\u4f30\u4eba\u6e90\u5316\u6297PD-1\u55ae\u514b\u9686\u6297\u9ad4QL1604\u5728\u665a\u671f\u6216\u8f49\u79fb\u6027\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\/\u85e5\u6548\u5b78\u548c\u6297\u816b\u7624\u7642\u6548\u7684\u9996\u6b21\u4eba\u9ad4\u3001\u958b\u653e\u3001\u5291\u91cf\u905e\u589e\u548c\u5291\u91cf\u64f4\u5c55\u7684I\u671f\u7814\u7a76\u300b\u3002\u8a72\u7814\u7a76\u662f\u827e\u5e15\u6d1b\u5229\u55ae\u6297\u9996\u6b21\u4eba\u9ad4\u7814\u7a76\uff0c\u7531\u6d59\u6c5f\u7701\u816b\u7624\u91ab\u9662\u8303\u96f2\u6559\u6388\u5718\u968a\u727d\u982d\u958b\u5c55\u3002<\/p>\n

\n<\/div>\n

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\uff08\u5b98\u7db2\u539f\u6587\u93c8\u63a5\uff1ahttps:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2023.1258573\/full\uff09<\/p>\n

\u4e00\uff0e\u00a0<\/b>\u7814\u7a76\u80cc\u666f\u548c\u76ee\u7684<\/b><\/p>\n

\u672c\u7814\u7a76\u662f\u827e\u5e15\u6d1b\u5229\u55ae\u6297\u5728\u665a\u671f\u6216\u8f49\u79fb\u6027\u5be6\u9ad4\u7624\u60a3\u8005\u4e2d\u958b\u5c55\u7684\u958b\u653e\u6a19\u7c64\u3001I\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u7814\u7a76\u7684\u4e3b\u8981\u76ee\u7684\u662f\u89c0\u5bdf\u827e\u5e15\u6d1b\u5229\u55ae\u6297\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\uff0c\u78ba\u5b9a\u5f8c\u7e8c\u81e8\u5e8a\u7814\u7a76\u7684\u63a8\u85a6\u5291\u91cf\u3002<\/p>\n

\u4e8c\uff0e\u00a0<\/b>\u7814\u7a76\u8a2d\u8a08\u548c\u60a3\u8005\u5206\u4f48<\/b><\/p>\n

\u672c\u7814\u7a76\u5305\u62ec\u5291\u91cf\u905e\u589e\u548c\u5291\u91cf\u64f4\u5c55\u5169\u500b\u968e\u6bb5\u30022019\u5e745\u670829\u65e5\u81f32020\u5e747\u670824\u65e5\uff0c\u517135\u4f8b\u60a3\u8005\u5165\u7d44\u4e26\u63a5\u53d7\u827e\u5e15\u6d1b\u5229\u55ae\u6297\u6cbb\u7642\u3002\u81f3\u6578\u64da\u622a\u6b62\u6642\u9593\uff082022\u5e747\u670814\u65e5\uff09\uff0c\u4ecd\u67094\u4f8b\u60a3\u8005\u5728\u63a5\u53d7\u6cbb\u7642\u3002<\/p>\n

\u4e09\uff0e\u00a0<\/b>\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u548c\u7642\u6548\u7d50\u679c<\/b><\/p>\n

\u5728\u827e\u5e15\u6d1b\u5229\u55ae\u62973 mg\/kg\u6bcf2\u54681\u6b21\uff08Q2W\uff09\u7d44\u76846\u4f8b\u60a3\u8005\u4e2d\uff0c1\u4f8b\uff0816.7%\uff09\u60a3\u8005\uff08\u80f8\u817a\u764c\uff09\u767c\u751f\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027\uff08DLT\uff09\uff0c\u70ba3\u7d1a\u91cd\u75c7\u808c\u7121\u529b\u548c\u514d\u75ab\u4ecb\u5c0e\u7684\u808c\u708e\u3002\u5728\u64ec\u5b9a\u6700\u9ad8\u905e\u589e\u5291\u91cf10 mg\/kg\u6c34\u5e73\u672a\u51fa\u73feDLT\uff0c\u56e0\u6b64\u672a\u627e\u5230\u660e\u78ba\u7684\u6700\u5927\u8010\u53d7\u5291\u91cf\uff08MTD\uff09\uff0c\u8010\u53d7\u6027\u826f\u597d\u3002<\/p>\n

\u5171\u670994.3%\uff0833\/35\uff09\u7684\u60a3\u8005\u767c\u751f\u4e0d\u826f\u4e8b\u4ef6\uff08AEs\uff09\uff0c\u5176\u4e2d82.9%\uff0829\/35\uff09\u70ba\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6(TRAEs)\u3002\u5b89\u5168\u6027\u7279\u5fb5\u8207\u65e2\u5f80\u5831\u9053\u7684PD-1\u55ae\u514b\u9686\u6297\u9ad4\u4e00\u81f4\u3002\u6700\u5e38\u898b\u7684TRAEs\uff08\u226510%\uff09\u70ba\u75b2\u52de\uff0837.1%\uff09\u3001\u8ca7\u8840\uff0822.9%\uff09\u3001\u8840\u4fc3\u7532\u72c0\u817a\u6fc0\u7d20\u589e\u52a0\uff0817.1%\uff09\u3001\u5929\u9580\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u5347\u9ad8\uff0817.1%\uff09\u3001\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u5347\u9ad8\uff0814.3%\uff09\u3001\u767d\u7d30\u80de\u8a08\u6578\u6e1b\u5c11\uff0811.4%\uff09\uff0c\u76ae\u75b9\uff0814.3%\uff09\u548c\u7619\u7662\uff0814.3%\uff09\u3002\u5927\u591a\u6578TRAEs\u70ba1\u81f32\u7d1a\u30023\u7d1a\u53ca\u4ee5\u4e0aTRAEs\u767c\u751f\u7387\u70ba17.1%\uff086\/35\uff09\u3002\u672a\u767c\u751f5\u7d1aTRAE\u3002<\/p>\n

\u5171\u670917\u4f8b\uff0848.6%\uff09\u60a3\u8005\u767c\u751f\u514d\u75ab\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08irAEs\uff09\uff0c\u6700\u5e38\u898b\u7684irAEs\u70ba\u8840\u4fc3\u7532\u72c0\u817a\u7d20\u5347\u9ad8\uff0817.1%\uff09\uff1b4\u4f8b\uff0811.4%\uff09\u60a3\u8005\u767c\u751f3\u7d1a\u53ca\u4ee5\u4e0airAEs\uff0c3\u4f8b\uff088.6%\uff09\u60a3\u8005\u767c\u751f\u8f38\u6ce8\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08\u5747\u70ba1-2\u7d1a\uff09\u3002<\/p>\n

\u5b89\u5168\u6027\u6578\u64da\u986f\u793a\uff0c\u827e\u5e15\u6d1b\u5229\u55ae\u6297\u5b89\u5168\u53ef\u7ba1\u7406\uff0c\u672a\u89c0\u5bdf\u5230\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f<\/p>\n

\u5171\u67097\u4f8b\uff0820.0%\uff09\u60a3\u8005\u9054\u5230\u90e8\u5206\u7de9\u89e3\uff08PR\uff09\uff0c5\u4f8b\uff0814.3%\uff09\u60a3\u8005\u9054\u5230\u75be\u75c5\u7a69\u5b9a\uff08SD\uff09\u3002\u5ba2\u89c0\u7de9\u89e3\u7387\uff08ORR\uff09\u70ba20.0%\uff087\/35\uff09\uff0c\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u70ba34.3%\uff0812\/35\uff09\u3002\uff08\u57163\uff09\u7de9\u89e3\u60a3\u8005\u7684\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08DOR\uff09\u70ba26.64\u500b\u6708\uff0895% CI\uff0c2.79-\u4e0d\u53ef\u8a55\u4f30\uff09\u3002<\/p>\n

\u56db\uff0e\u00a0<\/b>\u85e5\u52d5<\/b>\/<\/b>\u85e5\u6548\u5b78\u7d50\u679c<\/b><\/p>\n

\u57280.3 mg\/kg\u81f310 mg\/kg\u5291\u91cf\u7bc4\u570d\u5167\uff0c\u827e\u5e15\u6d1b\u5229\u55ae\u6297\u7684\u534a\u8870\u671f\uff08T1\/2<\/sub>\uff09\u70ba3\u81f311\u5929\uff0c\u85e5\u7269\u66b4\u9732\u8207\u5291\u91cf\u5448\u7dda\u6027\u95dc\u4fc2\u3002<\/p>\n

\u85e5\u6548\u5b78\u7d50\u679c\u986f\u793a\uff0c\u827e\u5e15\u6d1b\u5229\u55ae\u62973 mg\/kg Q2W, 3 mg\/kg Q3W, 10 mg\/kg Q2W\u548c200 mg Q3W\u56fa\u5b9a\u5291\u91cf\u7d66\u85e5\u5f8c\uff0c\u5728\u7d66\u85e5\u5f8c\u76841\u500b\u9031\u671f\u5167\uff0cPD-1\u5e73\u5747\u53d7\u9ad4\u4f54\u6709\u7387\uff08RO\uff09\u5747\u5927\u65bc80%\u3002<\/p>\n

\u4e94\uff0e\u00a0<\/b>\u7e3d\u7d50<\/b><\/p>\n

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\n\u65b0\u805e\u4f86\u6e90\uff1aPR Newswire<\/p>\n

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