{"id":94223,"date":"2023-11-06T12:20:00","date_gmt":"2023-11-06T04:20:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=94223"},"modified":"2023-11-06T12:20:00","modified_gmt":"2023-11-06T04:20:00","slug":"%e7%94%98%e8%90%8a%e5%9c%a8drugs-in-rd%e6%9c%9f%e5%88%8a%e4%b8%8a%e7%99%bc%e8%a1%a8%e6%96%b0%e5%9e%8b%e6%b3%95%e5%b0%bc%e9%86%87x%e5%8f%97%e9%ab%94%e6%bf%80%e5%8b%95%e5%8a%91asc42%e7%9a%84i%e6%9c%9f","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=94223","title":{"rendered":"\u7518\u840a\u5728Drugs in R&D\u671f\u520a\u4e0a\u767c\u8868\u65b0\u578b\u6cd5\u5c3c\u9187X\u53d7\u9ad4\u6fc0\u52d5\u5291ASC42\u7684I\u671f\u6578\u64da"},"content":{"rendered":"
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\u4e0a\u6d77<\/span>2023\u5e7411\u67086\u65e5<\/span> \/\u7f8e\u901a\u793e\/ \u2014\u00a0 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff09\u65d7\u4e0b\u5168\u8cc7\u5b50\u516c\u53f8\u7518\u840a\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u300c\u7518\u840a\u300d\uff09\u4eca\u65e5\u5ba3\u4f48\u65b0\u578b\u6cd5\u5c3c\u9187X\u53d7\u9ad4\uff08FXR\uff09\u6fc0\u52d5\u5291ASC42\u5728\u5065\u5eb7\u53d7\u8a66\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u85e5\u4ee3\u52d5\u529b\u5b78\uff08PK\uff09\u548c\u85e5\u6548\u5b78\uff08PD\uff09\u6578\u64da\u5df2\u5728Drugs in R&D<\/i>\u671f\u520a\u4e0a\u767c\u8868\u3002<\/i><\/p>\n

ASC42\u662f\u4e00\u6b3e\u7531\u7518\u840a\u81ea\u4e3b\u7814\u767c\u3001\u64c1\u6709\u5168\u7403\u77e5\u8b58\u7522\u6b0a\u3001\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\uff08best-in-class\uff09\u7684\u65b0\u578b\u9ad8\u6548\u9078\u64c7\u6027\u975e\u753e\u985eFXR\u6fc0\u52d5\u5291\u3002<\/p>\n

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\u4e00\u9805\u6d41\u884c\u75c5\u5b78\u7814\u7a76\u986f\u793a\uff0c<\/span>\u4e2d\u570b\u7684PBC\u60a3\u8005\u4eba\u6578\u7d04\u70ba65.6\u842c\uff0c\u5176\u4e2d40\u6b72\u4ee5\u4e0a\u5973\u6027\u60a3\u8005\u4eba\u6578\u70ba44\u842c[1]<\/sup>\u3002\u718a\u53bb\u6c27\u81bd\u9178\uff08UDCA\uff09\u662f\u76ee\u524d\u4e2d\u570b\u552f\u4e00\u7372\u6279\u7684\u6cbb\u7642PBC\u7684\u85e5\u7269\uff0c\u7d0440%\u7684PBC\u60a3\u8005\u5c0dUDCA\u61c9\u7b54\u4e0d\u8db3\u6216\u4e0d\u8010\u53d7[2]<\/sup>\u3002\u5967\u8c9d\u81bd\u9178\uff08OCA\uff09\u662f\u7f8e\u570b\u552f\u4e00\u7372\u6279\u7528\u65bc\u6cbb\u7642\u5c0dUDCA\u4e0d\u8010\u53d7\u6216\u61c9\u7b54\u4e0d\u8db3\u7684PBC\u60a3\u8005\u7684\u85e5\u7269\uff0c\u4f46\u4e26\u672a\u5728\u4e2d\u570b\u7372\u6279\u3002\u7136\u800cOCA\u6cbb\u7642\u6703\u4f7f\u60a3\u8005\u7684\u7619\u7662\u75c7\u767c\u751f\u7387\u5927\u5e45\u589e\u52a0\uff0c\u4e26\u5f15\u8d77LDL-C\u6c34\u5e73\u5347\u9ad8[3]<\/sup>\u3002<\/p>\n

2023\u5e747\u670820\u65e5\uff0c\u7518\u840a\u5ba3\u4f48ASC42\u6cbb\u7642PBC\u7684II\u671f\u81e8\u5e8a\u8a66\u9a57\u5df2\u5b8c\u6210\u60a3\u8005\u5165\u7d44\u3002<\/p>\n

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[1]\u00a0<\/sup>\u4e2d\u83ef\u91ab\u5b78\u6703\u98a8\u6fd5\u75c5\u5b78\u5206\u6703, \u539f\u767c\u6027\u81bd\u6c41\u6027\u81bd\u7ba1\u708e\u8a3a\u7642\u898f\u7bc4(2021)[J]. \u4e2d\u83ef\u5167\u79d1\u96dc\u8a8c, 2021, 60(8): 709-15. DOI: 10.3760\/cma.j.cn112138-20210520-00360.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[2]\u00a0<\/sup>Lindor K D, Bowlus C L, Boyer J, et al. Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases [J]. Hepatology 2019, 69(1): 394-419. DOI: 10.1002\/hep.30145.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[3]\u00a0<\/sup>Nevens, Frederik et al. \u300cA Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis.\u300d The New England journal of medicine vol. 375,7 (2016): 631-43. doi:10.1056\/NEJMoa1509840.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

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\u95dc\u65bc\u6b4c\u79ae<\/b><\/p>\n

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