{"id":94145,"date":"2023-11-06T08:00:00","date_gmt":"2023-11-06T00:00:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=94145"},"modified":"2023-11-06T08:00:00","modified_gmt":"2023-11-06T00:00:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%9c%a82023%e5%b9%b4%e7%be%8e%e5%9c%8b%e7%9c%bc%e7%a7%91%e5%ad%b8%e6%9c%83%ef%bc%88aao%ef%bc%89%e5%b9%b4%e6%9c%83%e5%85%ac%e4%bd%88%e5%89%b5%e6%96%b0%e7%9c%bc","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=94145","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u57282023\u5e74\u7f8e\u570b\u773c\u79d1\u5b78\u6703\uff08AAO\uff09\u5e74\u6703\u516c\u4f48\u5275\u65b0\u773c\u79d1\u96d9\u9776\u5019\u9078\u85e5\u7269IBI302\uff08\u6297VEGF\/\u88dc\u9ad4\uff09\u548cIBI324 (\u6297VEGF-A\/ANG-2)\u7684\u5169\u9805\u6700\u65b0\u81e8\u5e8a\u7814\u7a76\u7d50\u679c"},"content":{"rendered":"<div>\n<div>\n<p><span class=\"legendSpanClass\">\u7f8e\u570b\u99ac\u91cc\u862d\u5dde\u7f85\u514b\u7dad\u723e\u5e02\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2023\u5e7411\u67086\u65e5<\/span> \/\u7f8e\u901a\u793e\/ \u2014 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mg\u7d44<b>BCVA\u8f03\u57fa\u7dda\u8b8a\u5316\u5747\u503c\u5206\u5225\u70ba+10.6\u3001+11.4\u548c+12.0\u500b\u5b57\u6bcd<\/b>\u3002\u5404\u7d44\u9593\u5149\u5b78\u76f8\u5e72\u65b7\u5c64\u6383\u7784\uff08OCT\uff09\u6e2c\u91cf\u7684\u8996\u7db2\u819c\u4e2d\u592e\u539a\u5ea6\uff08CST\uff09\u6539\u5584\u60c5\u6cc1\u76f8\u7576\u3002<\/li>\n<li><b><span id=\"spanHghlt433f\">\u89c0\u5bdf\u5230IBI302\u9810\u9632\u9ec3\u6591\u840e\u7e2e\u548c\u7e96\u7dad\u5316\u767c\u751f\u7684\u521d\u6b65\u4fe1\u865f<\/span>\uff1a<\/b>\u7b2c52\u5468\u6642IBI302 2 mg\u7d44\u3001IBI302 4 mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2 mg\u7d44OCT\u4e0a\u9ec3\u6591\u840e\u7e2e\u7684\u767c\u751f\u7387\u5206\u5225\u70ba5.2%\u30015.2%\u30019.1%\uff1b\u5f69\u8272\u773c\u5e95\u7167\u76f8\u4e0a\u7e96\u7dad\u5316\u7684\u767c\u751f\u7387\u5206\u5225\u70ba16.9%\u300111.7%\u300114.3%\u3002<\/li>\n<li>\u5b89\u5168\u6027\u65b9\u9762\uff0cIBI302 2 mg\u7d44\u3001IBI302 4 mg\u7d44\u3001\u963f\u67cf\u897f\u666e 2 mg\u7d44\u5b89\u5168\u6027\u76f8\u7576\uff0cIBI302\u7d44\u7121\u773c\u5167\u708e\u6216\u8996\u7db2\u819c\u8840\u7ba1\u708e\u767c\u751f\u3002<\/li>\n<\/ul>\n<p><b>IBI324<\/b><b>\uff08\u6297VEGF-A\/Ang-2\u96d9\u7279\u7570\u6027\u6297\u9ad4\uff09\u6cbb\u7642\u7cd6\u5c3f\u75c5\u6027\u9ec3\u6591\u6c34\u816b\uff08DME\uff09\u7684I\u671f\u7814\u7a76<\/b><\/p>\n<p>\u6458\u8981\u7de8\u865f\uff1aPO524<\/p>\n<p>\u672c\u9805\u7814\u7a76\u70ba1\u671f\u81e8\u5e8a\u7814\u7a76\uff0c\u65e8\u5728\u8a55\u4f30IBI324\u6cbb\u7642DME\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u53ca\u6709\u6548\u6027\uff08\u7814\u7a76\u767b\u8a18\u865f\uff1aNCT05489718\uff09\u3002\u7814\u7a76\u5206\u70ba\u5169\u500b\u968e\u6bb5\uff0c\u55ae\u6b21\u7d66\u85e5\uff08SAD\uff09\u968e\u6bb5\u548c\u591a\u6b21\u7d66\u85e5\uff08MAD\uff09\u968e\u6bb5\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u5b89\u5168\u6027\u65b9\u9762\uff0c4 mg\/\u773c\u70ba\u7814\u7a76\u4e2d\u6700\u5927\u8010\u53d7\u5291\u91cf\u3002<b>\u7814\u7a76\u671f\u9593\u672a\u767c\u751f\u773c\u90e8\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u3001\u773c\u5167\u708e\u75c7\u53ca\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027<\/b>\u3002<\/li>\n<li>SAD\u968e\u6bb5\uff0c\u81f3\u7d66\u85e5\u5f8c\u7b2c42\u5929\uff0cIBI324\u5404\u5291\u91cf\u7d44BCVA\u548cCST\u5747\u8f03\u57fa\u7dda\u6709\u6240\u6539\u5584\u3002<\/li>\n<li>MAD\u968e\u6bb5\uff0c\u81f3\u7b2c\u4e09\u6b21\u7d66\u85e5\u5f8c4\u5468\uff08\u7b2c84\u5929\uff09\uff0cIBI324 2 mg\u548c4 mg\u7d44BCVA\u8f03\u57fa\u7dda\u5206\u5225\u6539\u55846.7\u00b15.4\u548c7.7\u00b14.7\u500b\u5b57\u6bcd\u3002<\/li>\n<\/ul>\n<p><b>\u5169\u9805\u81e8\u5e8a\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u4e0a\u6d77\u5e02\u7b2c\u4e00\u4eba\u6c11\u91ab\u9662\u526f\u9662\u9577\u3001<\/b>\u570b\u5bb6\u773c\u90e8\u75be\u75c5\u81e8\u5e8a\u91ab\u5b78\u4e2d\u5fc3\u4e3b\u4efb 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