{"id":118579,"date":"2024-01-23T12:13:00","date_gmt":"2024-01-23T04:13:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=118579"},"modified":"2024-01-23T12:13:00","modified_gmt":"2024-01-23T04:13:00","slug":"%e7%94%98%e8%90%8a%e6%88%b0%e7%95%a5%e5%90%88%e4%bd%9c%e5%a4%a5%e4%bc%b4sagimet-biosciences%e5%ae%a3%e4%bd%88asc40%ef%bc%88%e5%9c%b0%e5%b0%bc%e6%b3%95%e5%8f%b8%e4%bb%96%ef%bc%89%e6%b2%bb%e7%99%82","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=118579","title":{"rendered":"\u7518\u840a\u6230\u7565\u5408\u4f5c\u5925\u4f34Sagimet Biosciences\u5ba3\u4f48ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u6cbb\u7642\u7d93\u809d\u7a7f\u6d3b\u6aa2\u8b49\u5be6\u7e96\u7dad\u53162\/3\u671fNASH\u60a3\u8005\u7684IIb\u671fFASCINATE-2\u81e8\u5e8a\u8a66\u9a57\u53d6\u5f97\u7a4d\u6975\u9802\u7dda\u7d50\u679c"},"content":{"rendered":"<div>\n<div>\n<p><i>\u5728\u4e00\u9805\u91dd\u5c0d<\/i><i>168<\/i><i>\u4f8b\u7e96\u7dad\u5316<\/i><i>2<\/i><i>\u671f\u6216<\/i><i>3<\/i><i>\u671f<\/i><i>NASH<\/i><i>\u60a3\u8005\u9032\u884c\u7684<\/i><i>52<\/i><i>\u5468\u81e8\u5e8a\u8a66\u9a57\u4e2d\uff0c\u5730\u5c3c\u6cd5\u53f8\u4ed6\u5728\u4e3b\u8981\u7d42\u9ede\u548c\u591a\u500b\u6b21\u8981\u7d42\u9ede\u5747\u53d6\u5f97\u4e86\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\u7684\u7d50\u679c<\/i><\/p>\n<p class=\"prnml40\"><span id=\"spanHghltbb59\"><i><span id=\"spanHghltad6b\">\u2013\u00a0 \u00a0 \u00a0 <\/span>\u4e3b\u8981\u7642\u6548\u7d42\u9ede\uff1a<\/i><\/span><\/p>\n<ul type=\"disc\">\n<li style=\"list-style-type: none;\">\n<ul type=\"disc\">\n<li><i>\u5730\u5c3c\u6cd5\u53f8\u4ed6\u6cbb\u7642\u7d44<\/i><i>36%<\/i><i>\u7684\u60a3\u8005\u9054\u5230<\/i><i>NASH<\/i><i>\u6539\u5584\u4e14\u7e96\u7dad\u5316\u7121\u60e1\u5316\u4e14<\/i><i>NAS<\/i><i>\uff08<\/i><i>NAFLD<\/i><i>\u6d3b\u52d5\u5ea6\u8a55\u5206\uff09\u964d\u4f4e\u2265<\/i><i>2<\/i><i>\u5206\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba<\/i><i>13%<\/i><i>\uff08<\/i><i>p=0.002<\/i><i>\uff09<\/i><\/li>\n<li><i>\u5730\u5c3c\u6cd5\u53f8\u4ed6\u6cbb\u7642\u7d44<\/i><i>52%<\/i><i>\u7684\u60a3\u8005\u9054\u5230<\/i><i>NAS<\/i><i>\u964d\u4f4e\u2265<\/i><i>2<\/i><i>\u5206\u4e14\u7e96\u7dad\u5316\u7121\u60e1\u5316\uff0c\u800c\u5b89\u6170\u5291\u7d44\u70ba<\/i><i>20%<\/i><i>\uff08<\/i><i>p=0.0001<\/i><i>\uff09<\/i><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><i>\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d<\/i><\/p>\n<p><i>\u57fa\u65bc\u548c<\/i><i>Sagimet Biosciences Inc.<\/i><i>\u7684\u7368\u5bb6\u8a31\u53ef\u5354\u8b70\uff0c\u6b4c\u79ae\u7684\u5168\u8cc7\u5b50\u516c\u53f8\u7518\u840a\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u300c\u7518\u840a\u300d\uff09\u64c1\u6709<\/i><i>ASC40<\/i><i>\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u5728\u5927\u4e2d\u83ef\u5340\u7684\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u6b0a\u76ca<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2024\u5e741\u670823\u65e5<\/span> \/\u7f8e\u901a\u793e\/ \u2014 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u6b4c\u79ae\uff0c\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff09\u65d7\u4e0b\u5168\u8cc7\u5b50\u516c\u53f8\u7518\u840a\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u300c\u7518\u840a\u300d\uff09\u5ba3\u4f48\u5176\u6230\u7565\u5408\u4f5c\u5925\u4f34Sagimet Biosciences Inc.\uff08Sagimet\uff0c\u7d0d\u65af\u9054\u514b\uff1aSGMT\uff09<span id=\"spanHghlt7121\">\u4eca<\/span>\u65e5\u767c\u4f48\u4e86ASC40\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\uff09\u5c0d\u7167\u5b89\u6170\u5291\u6cbb\u7642\u7d93\u809d\u7a7f\u6d3b\u6aa2\u8b49\u5be6\u7684\u7e96\u7dad\u53162\u671f\u62163\u671f\uff08F2\/F3\uff09\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u60a3\u8005\u7684FASCINATE-2 IIb\u671f\u81e8\u5e8a\u8a66\u9a57\u5728\u7b2c52\u5468\u53d6\u5f97\u7684\u7a4d\u6975\u9802\u7dda\u7d50\u679c\u3002\u5728\u6b64\u9805\u8a66\u9a57\u4e2d\uff0c\u8207\u5b89\u6170\u5291\u76f8\u6bd4\uff0c\u53e3\u670d\u9078\u64c7\u6027FASN\u6291\u5236\u5291\u5730\u5c3c\u6cd5\u53f8\u4ed6\u5728\u5169\u500b\u4e3b\u8981\u7d42\u9ede\uff08NASH\u6539\u5584\u4e14\u7e96\u7dad\u5316\u7121\u60e1\u5316\u4e14NAS\u964d\u4f4e\u22652\u5206\uff0c\u4ee5\u53caNAS\u964d\u4f4e\u22652\u5206\u4e14\u7e96\u7dad\u5316\u7121\u60e1\u5316\uff09\u9054\u5230\u4e86\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\u7684\u6539\u5584\u3002\u8207\u5b89\u6170\u5291\u7d44\u76f8\u6bd4\uff0c\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7d44\u60a3\u8005\u7684\u7e96\u7dad\u5316\u6539\u5584\u22651\u671f\u4e14NASH\u7121\u60e1\u5316\u9054\u5230\u4e86\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\uff0c\u78c1\u5171\u632f\u8cea\u5b50\u5bc6\u5ea6\u8102\u80aa\u5206\u6578\uff08MRI-PDFF\uff09\u4e0b\u964d\u226530%\u7684\u61c9\u7b54\u8005\u6bd4\u4f8b\u66f4\u9ad8\u3002<\/p>\n<p>\u57fa\u65bc<span id=\"spanHghlt4139\">\u548cSagimet\u7684\u7368<\/span>\u5bb6\u8a31\u53ef\u5354\u8b70\uff0c\u7518\u840a\u64c1\u6709ASC40\u5728\u5927\u4e2d\u83ef\u5340\u7684\u958b\u767c\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u6b0a\u76ca\u3002\u6709\u95dc\u5ba3\u4f48FASCINATE-2\u7684IIb\u671f\u81e8\u5e8a\u7814\u7a76\u9802\u7dda\u7d50\u679c\u65b0\u805e\u53ef\u898b<b><a href=\"https:\/\/ir.sagimet.com\/news-releases\/news-release-details\/sagimet-biosciences-announces-positive-topline-results-phase-2b\" target=\"_blank\" rel=\"nofollow noopener\">\u6b64\u8655<\/a><\/b>\u3002\u00a0<\/p>\n<p>IIb\u671fFASCINATE-2\u9802\u7dda\u7d50\u679c<br \/><b>\u5730\u5c3c\u6cd5\u53f8\u4ed6\u6cbb\u7642\u7b2c<\/b><b>52<\/b><b>\u5468\u6642\uff0c\u4e3b\u8981\u7d42\u9ede\u548c\u5176\u4ed6\u7d42\u9ede\u7684\u6539\u5584\u9054\u5230\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570<\/b><\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prnpr2 prnpl2 prnvab prntac prncbts prnbrbrs prnbbbs prnsblb1\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5730\u5c3c\u6cd5\u53f8\u4ed6<\/b><br \/><b>50\u6beb\u514b(n=81)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5b89\u6170\u5291<\/b><br \/><b>(n=45)<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>P\u503c<\/b><br \/><b>\u5c0d\u6bd4\u5b89\u6170\u5291<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u4e3b\u8981\u7d42\u9ede<\/b><\/span><\/p>\n<\/td>\n<td class=\"prnpr10 prnpl2 prnvab prncbts prnbrbrs prnbbbs prnsblb1\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen2\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">NASH\u6539\u5584\u4e14\u7e96\u7dad\u5316\u7121\u60e1\u5316\u4e14NAS\u964d\u4f4e\u22652\u5206<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">36\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">13\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen5\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">NAS\u964d\u4f4e\u22652\u5206\u4e14\u7e96\u7dad\u5316\u7121\u60e1\u5316<\/span><\/p>\n<\/td>\n<td class=\"prngen4\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">52\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">20\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><b>\u5176\u4ed6\u7d42\u9ede<\/b><\/span><\/p>\n<\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\"><\/td>\n<td class=\"prngen10\" colspan=\"1\" rowspan=\"1\"><\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">\u7e96\u7dad\u5316\u6539\u5584\u22651\u5206\u4e14NASH\u7121\u60e1\u5316<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">41\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">18\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.005<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">NASH\u6539\u5584\u4e14\u7e96\u7dad\u5316\u7121\u60e1\u5316<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">38\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">16\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">\u4eba\u5de5\u667a\u80fd\u75c5\u7406\u7e96\u7dad\u5316\u8a55\u4f30(qFibrosis)*<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-0.3<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.1<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.002<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">ALT\u8f03\u57fa\u7dda\u8b8a\u5316\u7684\u767e\u5206\u6bd4<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-30.5\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-17.2\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">0.03<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">MRI-PDFF\u61c9\u7b54\u7387**<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">65\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">21\u00a0%<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">FibroScan AST (FAST)\u8a55\u5206<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-0.3<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-0.1<\/span><\/p>\n<\/td>\n<td class=\"prngen7\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><0.0001<\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen9\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml40\"><span class=\"prnews_span\">\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d(mg\/dL)***<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-19.1<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">-9.1<\/span><\/p>\n<\/td>\n<td class=\"prngen8\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">\u2014<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><i><span class=\"prnews_span\">\u6539\u826f\u610f\u5411\u6cbb\u7642\u4eba\u7fa4\uff08mITT\uff09\u5305\u62ec\u9032\u884c\u4e86\u5169\u6b21\u6d3b\u6aa2\u7684\u6240\u6709\u60a3\u8005\uff1b\u5305\u62ec\u622a\u81f3\u672c\u65b0\u805e\u7a3f\u767c\u4f48\u4e4b\u65e5\u5df2\u5b8c\u6210\u5206\u6790\u7684\u6b21\u8981\u7d42\u9ede<\/span><\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><i><span class=\"prnews_span\">*\u4eba\u5de5\u667a\u80fd\uff08AI\uff09\u6578\u5b57\u75c5\u7406\u8a55\u4f30\u57fa\u65bc\u4e8c\u6b21\u8ae7\u6ce2\u751f\u6210\uff08SHG\uff0cHistoIndex\uff09<\/span><\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><i><span class=\"prnews_span\">** MRI-PDFF\u97ff\u61c9\u662f\u6307\u6cbb\u7642\u7d50\u675f\u6642\u809d\u81df\u8102\u80aa\u76f8\u5c0d\u6e1b\u5c11\u226530%\u7684\u60a3\u8005<\/span><\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<tr>\n<td class=\"prngen11\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\"><i><span class=\"prnews_span\">***\u57fa\u7ddaLDL-C > 100 mg\/dL; \u5206\u5225\u5c0dn=32\u548cn=27\u7684\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7d44\u548c\u5b89\u6170\u5291\u7d44\u60a3\u8005\u9032\u884c\u63a2\u7d22\u6027\u5206\u6790<\/span><\/i><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\u00a0<\/p>\n<p><b>\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027<\/b><\/p>\n<p>\u8207\u4e4b\u524d\u7684\u7814\u7a76\u4e00\u6a23\uff0c\u672a\u89c0\u5bdf\u5230\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\uff0c\u5927\u591a\u6578\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u6027\u8cea\u70ba\u8f15\u81f3\u4e2d\u5ea6\uff081\u7d1a\u548c2\u7d1a\uff09\u3002\u7121\u22653\u7d1a\u8207\u6cbb\u7642\u76f8\u95dc\u7684AE\u3002\u6309\u7cfb\u7d71\u5668\u5b98\u5206\u985e\uff08\u5728\u672c\u7814\u7a76\u4e2d\u22655%\u7684\u60a3\u8005\u4e2d\u89c0\u5bdf\u5230\uff09\u6700\u5e38\u898b\u7684\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u773c\u90e8\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7d4415.2%\uff0c\u5b89\u6170\u5291\u7d4416.1%\uff09\u3001\u80c3\u8178\u9053\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7d4411.6%\uff0c\u5b89\u6170\u5291\u7d448.9%\uff09\u4ee5\u53ca\u76ae\u819a\u548c\u76ae\u4e0b\u7d44\u7e54\uff08\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7d4422.3%\uff0c\u5b89\u6170\u5291\u7d447.1%\uff09\u3002\u5c0e\u81f4\u6cbb\u7642\u505c\u6b62\u7684\u6cbb\u7642\u671f\u9593\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08TEAE\uff09\u767c\u751f\u7387\uff1a\u5730\u5c3c\u6cd5\u53f8\u4ed6\u7d44\u70ba19.6%\uff0c\u5b89\u6170\u5291\u7d44\u70ba5.4%\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>IIb<\/b><b>\u671f<\/b><b>FASCINATE-2<\/b><b>\u81e8\u5e8a\u8a66\u9a57<\/b><\/p>\n<p>IIb\u671fFASCINATE-2\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u70ba\u671f52\u5468\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u8a66\u9a57\uff0c\u5728168\u4f8b\u7d93\u809d\u7a7f\u6d3b\u6aa2\u8b49\u5be6\u7684NAS\u22654\u3001\u6709\u4e2d\u81f3\u91cd\u5ea6\u7e96\u7dad\u5316\uff08F2\u671f\u6216F3\u671f\uff09\u7684NASH\u60a3\u8005\u4e2d\u8a55\u4f30\u4e86\u5730\u5c3c\u6cd5\u53f8\u4ed6\u76f8\u8f03\u65bc\u5b89\u6170\u5291\u7684\u5b89\u5168\u6027\u548c\u7d44\u7e54\u5b78\u5f71\u97ff\u3002<\/p>\n<p><b>\u95dc\u65bc\u7518\u840a<\/b><\/p>\n<p>\u7518\u840a\u6210\u7acb\u65bc2019\u5e74\uff0c\u662f\u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\u7684\u5168\u8cc7\u5b50\u516c\u53f8\uff0c\u81f4\u529b\u65bcNASH\u9818\u57df\u65b0\u85e5\u7684\u7814\u767c\u548c\u5546\u696d\u5316\u3002\u7518\u840a\u6709\u4e09\u7a2e\u91dd\u5c0d\u4e09\u7a2e\u4e0d\u540c\u9776\u9ede\uff08FASN\u3001THR\u03b2\u548cFXR\uff09\u7684\u81e8\u5e8a\u968e\u6bb5\u5019\u9078\u85e5\u7269\uff0c\u4ee5\u53ca\u4e09\u7a2e\u806f\u5408\u7642\u6cd5\u3002<\/p>\n<p>\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554f<a href=\"http:\/\/www.gannexpharma.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.gannexpharma.com<\/a>\u3002<\/p>\n<p><b>\u95dc\u65bc\u6b4c\u79ae<\/b><\/p>\n<p>\u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3\u751f\u7522\u548c\u5546\u696d\u5316\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u805a\u7126\u4e09\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u75c5\u6bd2\u6027\u75be\u75c5\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u816b\u7624\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6191\u501f\u5353\u8d8a\u7684\u57f7\u884c\u529b\uff0c\u6b4c\u79ae\u5feb\u901f\u63a8\u9032\u85e5\u7269\u7ba1\u7dda\u958b\u767c\uff0c\u722d\u53d6\u5728\u570b\u969b\u7af6\u722d\u4e2d\u4f54\u64da\u9818\u5148\u5730\u4f4d\u3002\u6b4c\u79ae\u76ee\u524d\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269, \u6700\u524d\u6cbf\u7684\u5019\u9078\u85e5\u7269\u5305\u62ecASC22\uff08\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u7652\uff09\u3001ASC40\uff08\u75e4\u7621\uff09\u3001ASC40\uff08\u5fa9\u767c\u6027\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\uff09\u3001ASC40(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u3001ASC41(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u53caASC61\uff08\u665a\u671f\u5be6\u9ad4\u7624\uff09\u3002<\/p>\n<p>\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u656c\u8acb\u767b\u9304\u7db2\u7ad9\uff1a<a href=\"https:\/\/10.86.178.52\/C%24\/ConvertWordToHTML\/PrimaryContentDownloadPath\/www.ascletis.com\" target=\"_blank\" rel=\"nofollow noopener\">www.ascletis.com<\/a>\u3002<\/p>\n<\/div>\n<p>\n\u65b0\u805e\u4f86\u6e90\uff1aPR Newswire<\/p>\n<p>\u4ee5\u4e0a\u65b0\u805e\u6295\u7a3f\u5167\u5bb9\u7531PR Newswire \u7f8e\u901a\u793e\u5168\u6b0a\u81ea\u8ca0\u8cac\u4efb\uff0c\u82e5\u6709\u6d89\u53ca\u4efb\u4f55\u9055\u53cd\u6cd5\u4ee4\u3001\u9055\u53cd\u672c\u7db2\u7ad9\u6703\u54e1\u689d\u6b3e\u3001\u6709\u4fb5\u5bb3\u7b2c\u4e09\u4eba\u6b0a\u76ca\u4e4b\u865e\uff0c\u5c07\u4e00\u6982\u7531PR Newswire \u7f8e\u901a\u793e\u627f\u64d4\u6cd5\u5f8b\u53ca\u640d\u5bb3\u8ce0\u511f\u4e4b\u8cac\u4efb\uff0c\u8207\u65b0\u982d\u689dThehubnews\u7121\u95dc\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u5728\u4e00\u9805\u91dd\u5c0d168\u4f8b\u7e96\u7dad\u53162\u671f\u62163\u671fNASH\u60a3<\/p>\n","protected":false},"author":6,"featured_media":118580,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[423],"class_list":["post-118579","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-life","tag-423","two-columns"],"_links":{"self":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts\/118579","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=118579"}],"version-history":[{"count":0,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts\/118579\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/media\/118580"}],"wp:attachment":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=118579"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=118579"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=118579"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}