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\u4e0a\u6d77<\/span>2024\u5e741\u67084\u65e5<\/span> \/\u7f8e\u901a\u793e\/ \u2014 \u85e5\u660e\u5de8\u8afe\uff08\u6e2f\u4ea4\u6240\u4ee3\u78bc\uff1a2126\uff09\uff0c\u4e00\u5bb6\u5c08\u6ce8\u65bc\u958b\u767c\u3001\u751f\u7522\u53ca\u5546\u696d\u5316\u7d30\u80de\u514d\u75ab\u6cbb\u7642\u7522\u54c1\u7684\u7368\u7acb\u7684\u5275\u65b0\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u5ba3\u4f48\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5df2\u53d7\u7406\u5176\u9776\u5411CD19\u7684\u81ea\u9ad4\u5d4c\u5408\u6297\u539f\u53d7\u9ad4T\uff08CAR-T\uff09\u7d30\u80de\u514d\u75ab\u6cbb\u7642\u7522\u54c1\u500d\u8afe\u9054\u00ae<\/sup>\uff08\u745e\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff09\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\u6216\u96e3\u6cbb\u5957\u7d30\u80de\u6dcb\u5df4\u7624\uff08r\/r MCL\uff09\u60a3\u8005\u7684\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff08sBLA)\u3002\u9019\u662f\u85e5\u660e\u5de8\u8afe\u91dd\u5c0d\u500d\u8afe\u9054\u00ae<\/sup>\u905e\u4ea4\u7684\u7b2c\u4e09\u9805\u4e0a\u5e02\u8a31\u53ef\u7533\u8acb\uff0c\u4e26\u6709\u671b\u6210\u70ba\u9996\u500b\u5728\u4e2d\u570b\u6279\u51c6\u7528\u65bc\u6cbb\u7642r\/r MCL\u60a3\u8005\u7684\u7d30\u80de\u6cbb\u7642\u7522\u54c1\u3002\u500d\u8afe\u9054\u00ae<\/sup>\u65bc2022\u5e743\u6708\u88abNMPA\u6388\u4e88\u6cbb\u7642r\/r MCL\u7684\u7a81\u7834\u6027\u6cbb\u7642\u85e5\u7269\u8a8d\u5b9a\uff0c\u4e26\u65bc2023\u5e7412\u6708\u7372\u5f97\u512a\u5148\u5be9\u8a55\u8cc7\u683c\u3002<\/p>\n

MCL\u662f\u4e00\u7a2e\u7f55\u898b\u7684B\u7d30\u80de\u975e\u970d\u5947\u91d1\u6dcb\u5df4\u7624\uff0c\u7570\u8cea\u6027\u9ad8\uff0c\u76ee\u524d\u7121\u6cbb\u7652\u63aa\u65bd[1]<\/sup>\u3002MCL\u60a3\u8005\u4ee5\u8001\u5e74\u7537\u6027\u60a3\u8005\u70ba\u4e3b\uff0c\u8a3a\u65b7\u6642\u591a\u5df2\u8655\u65bc\u665a\u671f\uff0c\u9810\u5f8c\u8f03\u5dee[2]<\/sup>\u3002\u96d6\u8fd1\u5e74\u4f86\u6cbb\u7642\u65b9\u6848\u6709\u6240\u767c\u5c55\uff0c\u5f9e\u50b3\u7d71\u5316\u7642\u8f49\u8b8a\u70ba\u65b0\u578b\u9776\u5411\u85e5\u7269\u5982\u5e03\u9b6f\u9813\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08BTKi\uff09\u7b49\uff0c\u6539\u5584\u4e86\u90e8\u5206r\/r MCL\u60a3\u8005\u7684\u9810\u5f8c\uff0c\u4f46\u7d55\u5927\u591a\u6578\u60a3\u8005\u4ecd\u6703\u9032\u5c55\u6216\u5fa9\u767c\uff0c\u4e14\u6cbb\u7642\u5931\u6557\u7684\u60a3\u8005\u7e3d\u9ad4\u751f\u5b58\u671f\uff08OS\uff09\u8f03\u77ed\uff086~10\u500b\u6708\uff09[3]<\/sup>\u3002\u56e0\u6b64\uff0c\u4ecd\u9700\u958b\u767c\u5b89\u5168\u3001\u6709\u6548\u7684\u65b0\u7b56\u7565\uff0c\u4ee5\u514b\u670d\u76ee\u524dr\/r MCL\u6cbb\u7642\u7684\u5c40\u9650\u6027\u3002<\/p>\n

\u672c\u6b21\u65b0\u9069\u61c9\u75c7\u4e0a\u5e02\u7533\u8acb\u662f\u57fa\u65bc\u4e00\u9805\u5c07\u500d\u8afe\u9054\u00ae<\/sup>\u7528\u65bc\u6cbb\u7642r\/r MCL\u4e2d\u570b\u6210\u4eba\u53d7\u8a66\u8005\u7684\u55ae\u81c2\u3001\u591a\u4e2d\u5fc3\u3001\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\u7684\u7d50\u679c\u3002\u9019\u9805\u5728\u4e2d\u570b\u958b\u5c55\u76842\u671f\u55ae\u81c2\u958b\u653e\u7814\u7a76\u7d0d\u5165\u4e86\u63a5\u53d7\u904e\u9776\u5411CD20\u6297\u9ad4\u3001\u84bd\u74b0\u985e\u6216\u82ef\u9054\u83ab\u53f8\u6c40\u3001BTKi\u6cbb\u7642\u5f8c\u7684r\/r MCL\u53d7\u8a66\u8005\u3002\u53d7\u8a66\u8005\u5728\u6e05\u6dcb\u5316\u7642\u5f8c\u63a5\u53d7\u4e86100\u00d7106<\/sup> CAR+T\u7d30\u80de\u3002\u622a\u81f32023\u5e7410\u670825\u65e5\uff0c\u5df2\u5b8c\u621059\u4f8b\u53d7\u8a66\u8005\u7684\u56de\u8f38\uff0c\u57fa\u65bc56\u4f8b\u53ef\u9032\u884c\u7642\u6548\u8a55\u4f30\u7684\u53d7\u8a66\u8005\uff0c\u745e\u57fa\u5967\u4f96\u8cfd\u5c55\u73fe\u4e86\u826f\u597d\u7684\u81e8\u5e8a\u53cd\u61c9\uff0c\u5be6\u73fe\u4e86\u8f03\u9ad8\u7684ORR\u548cCRR\uff083\u500b\u6708\u7684\u6700\u4f73ORR\u70ba81.36%\uff0c3\u500b\u6708\u7684\u6700\u4f73CRR\u70ba66.10%\uff09\uff0c\u91cd\u5ea6\uff08\u22653\u7d1a\uff09\u7684\u7d30\u80de\u56e0\u5b50\u91cb\u653e\u7d9c\u5408\u5f81\uff08CRS\uff09\u767c\u751f\u7387\u70ba6.8%\uff0c\u91cd\u5ea6\uff08\u22653\u7d1a\uff09\u795e\u7d93\u6bd2\u6027\uff08NT\uff09\u7684\u767c\u751f\u7387\u70ba6.8%\u3002<\/p>\n

\u85e5\u660e\u5de8\u8afe\u9996\u5e2d\u91ab\u5b78\u5b98Mark J. Gilbert\u535a\u58eb\u8868\u793a\uff1a\u300c\u6211\u5011\u5f88\u9ad8\u8208\u6709\u4e00\u6b3e\u7522\u54c1\u80fd\u5920\u5c0d\u9019\u7a2e\u75be\u75c5\u7522\u751f\u6709\u610f\u7fa9\u7684\u7642\u6548\uff0c\u8fd1\u4e03\u6210\u5fa9\u767c\u6216\u96e3\u6cbb\u6027\u5957\u7d30\u80de\u6dcb\u5df4\u7624\u53d7\u8a66\u8005\u7d93\u745e\u57fa\u5967\u4f96\u8cfd\u6cbb\u7642\u5f8c\u7372\u5f97\u5b8c\u5168\u7de9\u89e3\uff0c\u5b89\u5168\u6027\u6578\u64da\u8868\u660e\uff0c\u8a72\u6cbb\u7642\u7e3d\u9ad4\u4e0a\u8010\u53d7\u6027\u826f\u597d\uff0c\u500d\u8afe\u9054\u00ae<\/sup>\u6709\u671b\u6210\u70ba\u4e2d\u570b\u7b2c\u4e00\u6b3e\u7528\u65bc\u6cbb\u7642\u5fa9\u767c\u6216\u96e3\u6cbb\u6027\u5957\u7d30\u80de\u6dcb\u5df4\u7624\u7684\u5546\u696d\u5316CAR-T\u7d30\u80de\u7522\u54c1\u3002\u300d<\/p>\n

\u53c3\u8003\u6587\u737b
[1].<\/sup> \u4e2d\u570b\u6297\u764c\u5354\u6703\u8840\u6db2\u816b\u7624\u5c08\u696d\u59d4\u54e1\u6703, \u4e2d\u83ef\u91ab\u5b78\u6703\u8840\u6db2\u5b78\u5206\u6703\u767d\u8840\u75c5\u6dcb\u5df4\u7624\u5b78\u7d44, \u4e2d\u570b\u6297\u6dcb\u5df4\u7624\u806f\u76df. \u5957\u7d30\u80de\u6dcb\u5df4\u7624\u8a3a\u65b7\u8207\u6cbb\u7642\u4e2d\u570b\u5c08\u5bb6\u5171\u8b58(2016\u5e74\u7248)[J]. \u4e2d\u83ef\u8840\u6db2\u5b78\u96dc\u8a8c, 2016, 37(9):735-741.
[2]. <\/sup>Herrmann A, Hoster E, Zwingers T, et al. Improvement of Overall Survival in Advanced Stage Mantle Cell Lymphoma[J]. Journal of Clinical Oncology, 2009, 27(4):511-518.
[3]. <\/sup>Burkart M, Karmali R. Relapsed\/Refractory Mantle Cell Lymphoma: Beyond BTK Inhibitors. J Pers Med. 2022 Mar 1<\/span>;12(3):376.<\/p>\n

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\u745e\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u7c21\u7a31\uff1arelma-cel\uff1b\u5546\u54c1\u540d\uff1a\u500d\u8afe\u9054\u00ae<\/sup>\uff09\u662f\u85e5\u660e\u5de8\u8afe\u5728\u5de8\u8afe\u91ab\u7642\uff08\u4e00\u5bb6\u767e\u6642\u7f8e\u65bd\u8cb4\u5bf6\u7684\u516c\u53f8\uff09\u7684CAR-T\u7d30\u80de\u5de5\u85dd\u5e73\u53f0\u7684\u57fa\u790e\u4e0a\uff0c\u81ea\u4e3b\u958b\u767c\u7684\u4e00\u6b3e\u9776\u5411CD19\u7684\u81ea\u9ad4CAR-T\u7d30\u80de\u514d\u75ab\u6cbb\u7642\u7522\u54c1\u3002\u4f5c\u70ba\u85e5\u660e\u5de8\u8afe\u7684\u9996\u6b3e\u7522\u54c1\uff0c\u500d\u8afe\u9054\u00ae<\/sup>\u5df2\u65bc2021\u5e749\u6708\u88ab\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u6279\u51c6\u7528\u65bc\u6cbb\u7642\u7d93\u904e\u4e8c\u7dda\u6216\u4ee5\u4e0a\u7cfb\u7d71\u6027\u6cbb\u7642\u5f8c\u6210\u4eba\u60a3\u8005\u7684\u5fa9\u767c\u6216\u96e3\u6cbb\u6027\u5927B\u7d30\u80de\u6dcb\u5df4\u7624\uff08r\/r LBCL\uff09\uff0c\u6210\u70ba\u4e2d\u570b\u9996\u500b\u7372\u6279\u70ba1\u985e\u751f\u7269\u88fd\u54c1\u7684CAR-T\u7522\u54c1\u3002\u500d\u8afe\u9054\u00ae<\/sup>\u662f\u4e2d\u570b\u76ee\u524d\u552f\u4e00\u4e00\u6b3e\u540c\u6642\u7372\u5f97\u300c\u91cd\u5927\u65b0\u85e5\u5275\u88fd\u300d\u5c08\u9805\u3001\u65b0\u85e5\u4e0a\u5e02\u7533\u8acb\u512a\u5148\u5be9\u8a55\u8cc7\u683c\u53ca\u7a81\u7834\u6027\u6cbb\u7642\u85e5\u7269\u8a8d\u5b9a\u7b49\u4e09\u9805\u6b8a\u69ae\u7684CAR-T\u7d30\u80de\u514d\u75ab\u6cbb\u7642\u7522\u54c1\u3002<\/p>\n

\u95dc\u65bc\u85e5\u660e\u5de8\u8afe<\/b><\/p>\n

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\n\u65b0\u805e\u4f86\u6e90\uff1aPR Newswire<\/p>\n

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