{"id":112426,"date":"2024-01-02T19:53:00","date_gmt":"2024-01-02T11:53:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=112426"},"modified":"2024-01-02T19:53:00","modified_gmt":"2024-01-02T11:53:00","slug":"%e7%94%98%e8%90%8aasc41%e8%82%9d%e7%a9%bf%e6%b4%bb%e6%aa%a2%e8%ad%89%e5%af%a6nash52%e5%91%a8%e2%85%b1%e6%9c%9f%e8%87%a8%e5%ba%8a%e5%8f%96%e5%be%97%e7%a9%8d%e6%a5%b5%e6%9c%9f%e4%b8%ad%e7%b5%90%e6%9e%9c","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=112426","title":{"rendered":"\u7518\u840aASC41\u809d\u7a7f\u6d3b\u6aa2\u8b49\u5be6NASH52\u5468\u2161\u671f\u81e8\u5e8a\u53d6\u5f97\u7a4d\u6975\u671f\u4e2d\u7d50\u679c"},"content":{"rendered":"
\n
\n

\u2013\u7d93\u809d\u7a7f\u6d3b\u6aa2\u8b49\u5be6\u7684\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u60a3\u8005\u670d\u7528ASC41\u724712\u5468\u5f8c\uff0c\u809d\u81df\u8102\u80aa\u542b\u91cf\u8f03\u57fa\u7dda\u7684\u76f8\u5c0d\u964d\u5e45\u5e73\u5747\u503c\u9ad8\u905468.2%\u00a0<\/i><\/p>\n

\u2013\u7b2c12\u5468\u6642\uff0c\u9ad8\u905493.3%\u7684\u60a3\u8005\u809d\u81df\u8102\u80aa\u542b\u91cf\u8f03\u57fa\u7dda\u76f8\u5c0d\u964d\u4f4e30%\u53ca\u4ee5\u4e0a<\/i><\/p>\n

\u2013\u7b2c12\u5468\u6642\uff0c\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\u7684\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u548c\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u8f03\u57fa\u7dda\u76f8\u5c0d\u964d\u5e45\u5e73\u5747\u503c\u5206\u5225\u9ad8\u905437.8%\u548c41.5%<\/i><\/p>\n

\u2013\u7b2c12\u5468\u6642\uff0c\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\u7684\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u3001\u7e3d\u81bd\u56fa\u9187\uff08TC\uff09\u548c\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u8f03\u57fa\u7dda\u76f8\u5c0d\u964d\u5e45\u5e73\u5747\u503c\u5206\u5225\u9ad8\u905427.7%\u300123.4%\u548c46.5%<\/i><\/p>\n

\u2013\u670d\u7528ASC41\u7247\u60a3\u8005\u8207\u670d\u7528\u5b89\u6170\u5291\u60a3\u8005\u4e2d\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u76f8\u4f3c\uff0c\u5305\u62ec\u80c3\u8178\u9053\uff08GI\uff09\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\u00a0<\/i><\/p>\n

\u4e0a\u6d77<\/span>2024\u5e741\u67082\u65e5<\/span> \/\u7f8e\u901a\u793e\/ \u2014 \u6b4c\u79ae\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u4ee3\u78bc\uff1a1672\uff0c\u300c\u6b4c\u79ae\u300d\uff09\u65d7\u4e0b\u5168\u8cc7\u5b50\u516c\u53f8\u7518\u840a\u88fd\u85e5\u6709\u9650\u516c\u53f8\uff08\u300c\u7518\u840a\u300d\uff09\u4eca\u65e5\u5ba3\u4f48\u7532\u72c0\u817a\u6fc0\u7d20\u53d7\u9ad4\u03b2\uff08THR\u03b2\uff09\u6fc0\u52d5\u5291ASC41\u7247\u7528\u65bc\u6cbb\u7642\u7d93\u809d\u7a7f\u6d3b\u6aa2\u8b49\u5be6\u7684\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\uff08NASH\uff09\u60a3\u8005\u768452\u5468\u2161\u671f\u81e8\u5e8a\u8a66\u9a57\u53d6\u5f97\u7a4d\u6975\u671f\u4e2d\u7d50\u679c\u3002ASC41\u5177\u6709\u809d\u81df\u9776\u5411\u6027\u548c\u9ad8\u5ea6\u7684THR\u03b2\u9078\u64c7\u6027\u3002\u4e00\u65e5\u670d\u7528\u4e00\u6b21\u7684ASC41\u7247\u5291\u7531\u6b4c\u79ae\u5c08\u6709\u5236\u5291\u6280\u8853\u958b\u767c\u3002ASC41\u7247\u5291\u5236\u5291\u5c08\u5229\u5df2\u5728\u7f8e\u570b\u7372\u5f97\u6388\u6b0a\u3002\u00a0<\/p>\n

\u8a72\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u53ca\u591a\u4e2d\u5fc3\u7684II\u671f\u81e8\u5e8a\u8a66\u9a57\uff08ClinicalTrials.gov: NCT05462353<\/a>\uff09\u6b63\u5728\u4e2d\u570b\u958b\u5c55\uff0c\u9810\u8a08\u5165\u7d44\u7d04180\u540d\u7d93\u809d\u7a7f\u6d3b\u6aa2\u8b49\u5be6\u7684NASH\u60a3\u8005\uff0c\u4ee51:1:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u914d\u9032\u5165\u5169\u500bASC41\u7247\u6cbb\u7642\u968a\u5217\uff082\u6beb\u514b\u62164\u6beb\u514b\uff0c\u4e00\u65e5\u4e00\u6b21\uff09\u548c\u4e00\u500b\u5b89\u6170\u5291\u5c0d\u7167\u968a\u5217\uff0c\u6cbb\u764252\u5468\u4e26\u96a8\u8a2a4\u5468\u3002\u9810\u8a2d\u7684\u671f\u4e2d\u5206\u6790\u572842\u540d\u5165\u7d44\u60a3\u8005\u5b8c\u6210\u70ba\u671f12\u5468\u7684ASC41\u7247\u6216\u5b89\u6170\u5291\u6cbb\u7642\u5f8c\u9032\u884c\u3002<\/p>\n

\u671f\u4e2d\u7d50\u679c<\/b>:<\/b><\/p>\n

\u7b2c<\/b>12<\/b>\u5468\u809d\u81df\u8102\u80aa\u542b\u91cf\u8f03\u57fa\u7dda\u964d\u4f4e<\/b><\/p>\n

\u7d93\u78c1\u5171\u632f\u6210\u50cf\u8cea\u5b50\u5bc6\u5ea6\u8102\u80aa\u5206\u6578\uff08MRI-PDFF\uff09\u8a55\u4f30\uff0c\u670d\u7528ASC41\u7247\u7684\u60a3\u8005\u809d\u81df\u8102\u80aa\u542b\u91cf\u964d\u4f4e\u8207\u670d\u7528\u5b89\u6170\u5291\u7684\u60a3\u8005\u76f8\u6bd4\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\uff08\u88681\uff09\u3002\u5728\u670d\u7528ASC41\u7247\u7684\u60a3\u8005\u4e2d\uff0c\u9ad8\u905493.3%\u7684\u60a3\u8005\u809d\u81df\u8102\u80aa\u542b\u91cf\u8f03\u57fa\u7dda\u76f8\u5c0d\u964d\u4f4e30%\u53ca\u4ee5\u4e0a\uff0c\u809d\u81df\u8102\u80aa\u542b\u91cf\u964d\u4f4e30%\u53ca\u4ee5\u4e0a<\/span>\u8207\u60a3\u8005\u5be6\u73feNASH\u7d44\u7e54\u5b78\u6539\u5584\u9ad8\u5ea6\u76f8\u95dc\uff0c\u5c24\u5176\u662f\u5c0dTHR\u03b2\u6fc0\u52d5\u5291\u6cbb\u7642\u7684\u60a3\u8005\u800c\u8a00\u3002<\/p>\n

\u8868<\/b>1. <\/b>\u7d93<\/b>MRI-PDFF<\/b>\u8a55\u4f30\u7684\u7b2c<\/b>12<\/b>\u5468\u809d\u81df\u8102\u80aa\u542b\u91cf\u964d\u4f4e<\/b><\/p>\n

\n\n\n\n\n\n\n\n\n
<\/td>\n\n

\u5b89\u6170\u5291<\/span><\/b><\/span><\/p>\n

(n = 14)<\/span><\/b><\/span><\/p>\n<\/td>\n

\n

ASC41<\/span><\/b>\u7247<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2<\/span><\/b>\u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/b><\/span><\/p>\n

(n = 13)<\/span><\/b><\/span><\/p>\n<\/td>\n

\n

4<\/span><\/b>\u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/b><\/span><\/p>\n

(n = 15)<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u5e73\u5747\u503c<\/span><\/p>\n<\/td>\n

\n

18.2\u00a0%<\/span><\/p>\n<\/td>\n

\n

17.8\u00a0%<\/span><\/p>\n<\/td>\n

\n

18.9\u00a0%<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u809d\u81df\u8102\u80aa\u542b\u91cf\u8f03\u57fa\u7dda\u7684\u76f8\u5c0d\u8b8a\u5316\u5e73\u5747\u503c<\/span><\/p>\n<\/td>\n

\n

-13.1\u00a0%<\/span><\/p>\n<\/td>\n

\n

-55.0%<\/span><\/p>\n

(p = 0.0001 <\/span>\u5c0d\u6bd4\u5b89\u6170\u5291<\/span>)<\/span><\/p>\n<\/td>\n

\n

-68.2%<\/span><\/p>\n

(p < 0.0001\u00a0<\/span>\u5c0d\u6bd4\u5b89\u6170\u5291<\/span>)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u809d\u81df\u8102\u80aa\u542b\u91cf\u8f03\u57fa\u7dda\u7684\u76f8\u5c0d\u8b8a\u5316\u4e2d\u4f4d\u6578<\/span><\/p>\n<\/td>\n

\n

-5.8\u00a0%<\/span><\/p>\n<\/td>\n

\n

-48.8\u00a0%<\/span><\/p>\n<\/td>\n

\n

-70.1\u00a0%<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u809d\u81df\u8102\u80aa\u542b\u91cf\u8f03\u57fa\u7dda\u76f8\u5c0d\u964d\u4f4e<\/span>\u2265<\/span>30%<\/span>\u7684\u60a3\u8005\u6bd4\u4f8b<\/span><\/p>\n<\/td>\n

\n

21.4\u00a0%<\/span><\/p>\n<\/td>\n

\n

92.3%<\/span><\/p>\n

(p = 0.0002 <\/span>\u5c0d\u6bd4\u5b89\u6170\u5291<\/span>)<\/span><\/p>\n<\/td>\n

\n

93.3%<\/span><\/p>\n

(p < 0.0001 <\/span>\u5c0d\u6bd4\u5b89\u6170\u5291<\/span>)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u00a0<\/p>\n

\u7b2c<\/b>12<\/b>\u5468\u809d\u81df\u708e\u75c7\u751f\u7269\u6a19\u8a8c\u7269\u8f03\u57fa\u7dda\u964d\u4f4e<\/b><\/p>\n

ASC41\u7247\u968a\u5217\u548c\u5b89\u6170\u5291\u968a\u5217\u7684\u57fa\u7dda\u5e73\u5747\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08ALT\uff09\u548c\u5929\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\uff08AST\uff09\u7bc4\u570d\u5206\u5225\u70ba65.9\u81f384.8 U\/L\u548c44.2\u81f353.8 U\/L\u3002\u7b2c12\u5468\u6642\uff0c\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\u7684ALT\u548cAST\u8f03\u57fa\u7dda\u7d55\u5c0d\u4e0b\u964d\u7684\u5e73\u5747\u503c\u5206\u5225\u9ad8\u905434.2 U\/L\u548c21.4 U\/L\u3002\u7b2c12\u5468\u6642\uff0c\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\u7684ALT\u548cAST\u8f03\u57fa\u7dda\u76f8\u5c0d\u964d\u5e45\u7684\u5e73\u5747\u503c\u5206\u5225\u9ad8\u905437.8%\u548c41.5%\u3002\u6b64\u5916\uff0c\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\uff0cALT\u5e73\u5747\u4e0b\u964d\u5927\u65bc17 U\/L\u7684\u60a3\u8005\u6bd4\u4f8b\u9ad8\u905451.9%\u3002\u4e0a\u8ff0ASC41\u7247\u968a\u5217\u6240\u6709ALT\u548cAST\u8b8a\u5316\u8207\u5b89\u6170\u5291\u968a\u5217\u76f8\u6bd4\u5747\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\u3002<\/p>\n

ALT\u548cAST\u662f\u8a55\u4f30\u809d\u640d\u50b7\u548c\u809d\u529f\u80fd\u7570\u5e38\u7684\u91cd\u8981\u751f\u7269\u6a19\u8a8c\u7269\u3002NASH\u60a3\u8005\u8840\u6e05ALT\u7684\u4e0b\u964d\u8207\u809d\u81df\u7d44\u7e54\u5b78\u7684\u6539\u5584\u6709\u95dc\u3002\u8207\u5b89\u6170\u5291\u5c0d\u6bd4\uff0c\u5728\u670d\u7528ASC41\u7247\u7684\u60a3\u8005\u4e2d\u89c0\u5bdf\u5230\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\u4e14\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684ALT\u548cAST\u964d\u4f4e\uff0c\u9019\u662fASC41\u7247\u8207\u5176\u4ed6\u6b63\u5728\u81e8\u5e8a\u6216\u8a3b\u518a\u968e\u6bb5THR\u03b2\u6fc0\u52d5\u5291\u7684\u986f\u8457\u5dee\u7570\u3002<\/p>\n

\u7b2c<\/b>12<\/b>\u5468\u8840\u8102\u8f03\u57fa\u7dda\u964d\u4f4e<\/b><\/p>\n

\u8207\u4e4b\u524d\u7684\u7814\u7a76\u7d50\u679c\u4e00\u81f4\uff0c\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\uff0c\u670d\u7528ASC41\u7247\u7684\u60a3\u8005\u4f4e\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08LDL-C\uff09\u3001\u7e3d\u81bd\u56fa\u9187\uff08TC\uff09\u548c\u7518\u6cb9\u4e09\u916f\uff08TG\uff09\u8f03\u57fa\u7dda\u5e73\u5747\u964d\u5e45\u5206\u5225\u9ad8\u905427.7%\u300123.4%\u548c46.5%\uff08\u88682\uff09\uff0c\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\u4e14\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u3002\u670d\u7528ASC41\u7247\u6216\u5b89\u6170\u5291\u7684\u968a\u5217\u7684\u9ad8\u5bc6\u5ea6\u8102\u86cb\u767d\u81bd\u56fa\u9187\uff08HDL-C\uff09\u8f03\u57fa\u7dda\u4fdd\u6301\u4e0d\u8b8a\u3002\u7d93\u5b89\u6170\u5291\u6821\u6b63\u5f8c\uff0c\u670d\u7528ASC41\u7247\u7684\u60a3\u8005\u8102\u86cb\u767d\uff08a\uff09\uff08Lp(a)\uff09\u4e0b\u964d\u5e73\u5747\u503c\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\u3002\u9019\u4e9b\u8840\u8102\u7684\u964d\u4f4e\u53ef\u6539\u5584\u60a3\u8005\u7684\u6574\u9ad4\u5fc3\u81df\u4ee3\u8b1d\u72c0\u6cc1\uff0c\u4e26\u53ef\u80fd\u964d\u4f4e\u5fc3\u8840\u7ba1\u76f8\u95dc\u4e8b\u4ef6\u7684\u98a8\u96aa\u3002<\/p>\n

\u8868<\/b>2. <\/b>\u7b2c<\/b>12<\/b>\u5468\u8840\u8102\u8f03\u57fa\u7dda\u964d\u4f4e<\/b><\/p>\n

\n\n\n\n\n\n\n\n
<\/td>\n\n

\u5b89\u6170\u5291<\/span><\/b><\/span><\/p>\n

(n = 14)<\/span><\/b><\/span><\/p>\n<\/td>\n

\n

ASC41<\/span><\/b>\u7247<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2<\/span><\/b>\u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/b><\/span><\/p>\n

(n = 13)<\/span><\/b><\/span><\/p>\n<\/td>\n

\n

4<\/span><\/b>\u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/b><\/span><\/p>\n

(n =15)<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

LDL-C<\/span>\uff0c\u8f03\u57fa\u7dda\u8b8a\u5316\u5e73\u5747\u503c<\/span><\/p>\n<\/td>\n

\n

4.3\u00a0%<\/span><\/p>\n<\/td>\n

\n

-19.4%<\/span><\/p>\n

\uff08<\/span>p = 0.0002\u5c0d\u6bd4\u5b89\u6170\u5291<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

-23.4%<\/span><\/p>\n

\uff08<\/span>p < 0.0001\u5c0d\u6bd4\u5b89\u6170\u5291<\/span>\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

TC<\/span>\uff0c\u8f03\u57fa\u7dda\u8b8a\u5316\u5e73\u5747\u503c<\/span><\/p>\n<\/td>\n

\n

3.4\u00a0%<\/span><\/p>\n<\/td>\n

\n

-16.8%<\/span><\/p>\n

\uff08<\/span>p < 0.0001\u5c0d\u6bd4\u5b89\u6170\u5291<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

-20.0%<\/span><\/p>\n

\uff08<\/span>p < 0.0001\u5c0d\u6bd4\u5b89\u6170\u5291<\/span>\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

TG<\/span>\uff0c\u8f03\u57fa\u7dda\u8b8a\u5316\u5e73\u5747\u503c<\/span><\/p>\n<\/td>\n

\n

3.9\u00a0%<\/span><\/p>\n<\/td>\n

\n

-30.6%<\/span><\/p>\n

\uff08<\/span>p = 0.0001\u5c0d\u6bd4\u5b89\u6170\u5291<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

-42.6%<\/span><\/p>\n

\uff08<\/span>p < 0.0001\u5c0d\u6bd4\u5b89\u6170\u5291<\/span>\uff09<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u00a0<\/p>\n

\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027<\/b><\/p>\n

ASC41\u7247\u986f\u793a\u51fa\u4e86\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u3002ASC41\u7247\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\uff0c\u5404\u968a\u5217\uff08\u5305\u62ec\u5b89\u6170\u5291\u968a\u5217\uff09\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08AE\uff09\u5927\u90e8\u5206\u70ba1\u7d1a\uff08\u88683\uff09\u3002\u5728\u670d\u7528ASC41\u7247\u7684\u60a3\u8005\u4e2d\uff0c\u53ea\u6709\u5169\u540d\u60a3\u8005\uff082\/28\uff0c7.1%\uff09\u5831\u544a\u4e86\u8207\u85e5\u7269\u76f8\u95dc\u76842\u7d1a\u6cbb\u7642\u671f\u51fa\u73fe\u7684\u4e0d\u826f\u4e8b\u4ef6\uff08treatment emergent adverse events, TEAE\uff09\u3002\u5728\u6240\u6709\u670d\u7528ASC41\u7247\u7684\u60a3\u8005\u4e2d\uff0c\u672a\u89c0\u5bdf\u5230\u8207\u85e5\u7269\u76f8\u95dc\u76843\u7d1a\u6216\u66f4\u9ad8\u7d1a\u5225\u7684TEAE\u3002\u5728\u670d\u7528ASC41\u7247\u7684\u60a3\u8005\u4e2d\uff0c\u53ea\u6709\u4e00\u540d\u60a3\u8005\uff081\/28\uff0c3.6%\uff09\u56e0\u85e5\u7269\u76f8\u95dc\u76841\u7d1aTEAE\u800c\u9000\u51fa\u7814\u7a76\u3002\u670d\u7528ASC41\u7247\u6216\u5b89\u6170\u5291\u7684\u60a3\u8005\u5747\u672a\u5831\u544a\u8207\u6cbb\u7642\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\uff08SAE\uff09\u3002\u8207\u4e4b\u524d\u7684\u7814\u7a76\u4e00\u6a23\uff0cASC41\u7247\u986f\u793a\u51fa\u4e86\u826f\u597d\u7684\u80c3\u8178\u9053\uff08GI\uff09\u8010\u53d7\u6027\u3002\u5728\u670d\u7528ASC41\u7247\u7684\u60a3\u8005\u4e2d\uff0c\u5641\u5fc3\u3001\u5614\u5410\u3001\u8179\u7009\u3001\u8179\u8139\u3001\u8179\u75db\uff08\u4e0a\u8179\u90e8\uff09\u3001\u4fbf\u79d8\u3001\u6d88\u5316\u4e0d\u826f\u548c\u983b\u7e41\u6392\u4fbf\u7684\u767c\u751f\u7387\u4f4e\uff08\u88683\uff09\u3002ASC41\u7247\u6cbb\u7642\u968a\u5217\u8207\u5b89\u6170\u5291\u968a\u5217\u7684\u7532\u72c0\u817a\u8ef8\u6fc0\u7d20\u6c34\u5e73\u8f03\u57fa\u7dda\u90fd\u76f8\u5c0d\u4e0d\u8b8a\uff0c\u5305\u62ec\u4fc3\u7532\u72c0\u817a\u6fc0\u7d20\uff08TSH\uff09\u3001\u6e38\u96e2\u4e09\u7898\u7532\u72c0\u817a\u539f\u6c28\u9178\uff08fT3\uff09\u548c\u6e38\u96e2\u7532\u72c0\u817a\u7d20\uff08fT4\uff09\u3002\u670d\u7528ASC41\u7247\u7684\u60a3\u8005\u8207\u670d\u7528\u5b89\u6170\u5291\u7684\u60a3\u8005\u5728\u751f\u547d\u9ad4\u5f81\u548c\u5fc3\u96fb\u5716\uff08ECG\uff09\u7684\u8b8a\u5316\u76f8\u4f3c\u3002<\/p>\n

\u8868<\/b>3. <\/b>\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u6578\u64da<\/b><\/p>\n

\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
<\/td>\n\n

\u5b89\u6170\u5291<\/span><\/b><\/span><\/p>\n

\uff08<\/span><\/b>n = 14<\/span><\/b>\uff09<\/span><\/b><\/span><\/p>\n<\/td>\n

\n

ASC41<\/span><\/b>\u7247<\/span><\/b>\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2<\/span><\/b>\u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/b><\/span><\/p>\n

\uff08<\/span><\/b>n = 13<\/span><\/b>\uff09<\/span><\/b><\/span><\/p>\n<\/td>\n

\n

4<\/span><\/b>\u6beb\u514b\uff0c\u6bcf\u65e5\u4e00\u6b21<\/span><\/b>\u00a0<\/span><\/p>\n

\uff08<\/span><\/b>n = 15<\/span><\/b>\uff09<\/span><\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

TEAE[1]
<\/sup><\/span>\u53d7\u8a66\u8005\u6578\u91cf\uff08<\/span>%<\/span>\uff09<\/span><\/p>\n<\/td>\n

\n

13(92.9\u00a0%)<\/span><\/p>\n<\/td>\n

\n

13(100\u00a0%)<\/span><\/p>\n<\/td>\n

\n

15(100\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u85e5\u7269\u76f8\u95dc<\/span>TEAE[2]<\/sup><\/span><\/p>\n<\/td>\n

\n

6(42.9\u00a0%)<\/span><\/p>\n<\/td>\n

\n

7(53.9\u00a0%)<\/span><\/p>\n<\/td>\n

\n

7(46.7\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

1<\/span>\u7d1a<\/span><\/p>\n<\/td>\n

\n

6(42.9\u00a0%)<\/span><\/p>\n<\/td>\n

\n

7(53.9\u00a0%)<\/span><\/p>\n<\/td>\n

\n

7(46.7\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u85e5\u7269\u76f8\u95dc\u7684<\/span>GI<\/span>\u4e0d\u826f\u4e8b\u4ef6<\/span><\/p>\n<\/td>\n

\n

2(14.3\u00a0%)<\/span><\/p>\n<\/td>\n

\n

3(23.1\u00a0%)<\/span><\/p>\n<\/td>\n

\n

1(6.7\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5641\u5fc3<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5614\u5410<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8179\u7009<\/span><\/p>\n<\/td>\n

\n

1(7.1\u00a0%)<\/span><\/p>\n<\/td>\n

\n

3(23.1\u00a0%)<\/span><\/p>\n<\/td>\n

\n

1(6.7\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8179\u8139<\/span><\/p>\n<\/td>\n

\n

1(7.1\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u8179\u75db\uff08\u4e0a\u8179\u90e8\uff09<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u4fbf\u79d8<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u6d88\u5316\u4e0d\u826f<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u983b\u7e41\u6392\u4fbf<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n

\n

0(0.0\u00a0%)<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\n\n\n\n\n\n\n
\n

\u8a3b\uff1a<\/i><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\u5b89\u5168\u6027\u7814\u7a76\u7fa4\u9ad4\uff0c\u5b9a\u7fa9\u70ba\u6240\u6709\u88ab\u96a8\u6a5f\u5206\u7d44\u4e26\u63a5\u53d7\u81f3\u5c11\u4e00\u5291\u7814\u7a76\u85e5\u7269\u7684\u60a3\u8005\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[1] \u6578\u64da\u622a\u81f32023\u5e7411\u670822\u65e5\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[2] \u7814\u7a76\u8005\u8a8d\u70ba\u53ef\u80fd\u3001\u5927\u6982\u6216\u80af\u5b9a\u8207\u7814\u7a76\u85e5\u7269\u76f8\u95dc\u3002<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u00a0<\/p>\n

\u300c\u975e\u5e38\u9ad8\u8208\u6211\u5011\u5728\u7d93\u809d\u7a7f\u6d3b\u6aa2\u8b49\u5be6\u7684NASH\u60a3\u8005\u4e2d\u9032\u884c\u7684II\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u7372\u5f97\u4e86\u7a4d\u6975\u671f\u4e2d\u7d50\u679c\uff0c\u9019\u8868\u660eASC41\u7247\u6709\u671b\u6210\u70ba\u540c\u985e\u6700\u4f73\u7684THR\u03b2\u6fc0\u52d5\u5291\u3002\u7279\u5225\u662f\u6211\u5011\u5728\u9ad8\u905493.3%\u7684\u60a3\u8005\u4e2d\u89c0\u5bdf\u5230\u4e86\u8f03\u57fa\u7dda\u226530%\u7684\u809d\u81df\u8102\u80aa\u542b\u91cf\u76f8\u5c0d\u964d\u4f4e\uff08\u61c9\u7b54\u7387\uff09\uff0c\u61c9\u7b54\u7387\u662f\u9810\u6e2cTHR\u03b2\u6fc0\u52d5\u5291\u985e\u85e5\u7269\u6cbb\u7642NASH\u9054\u5230NASH\u6539\u5584\u4e14\u7e96\u7dad\u5316\u6539\u5584\u22651\u968e\u6bb5\u7684\u95dc\u9375\u6307\u6a19\u3002\u6b64\u5916\uff0c\u5728\u670d\u752812\u5468ASC41\u7247\u7684\u60a3\u8005\u4e2d\u9084\u89c0\u5bdf\u5230\u4e86\u5177\u6709\u7d71\u8a08\u5b78\u986f\u8457\u6027\u5dee\u7570\u4e14\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684ALT\u548cAST\u964d\u4f4e\uff0c\u9019\u662fASC41\u7247\u8207\u5176\u4ed6\u6b63\u5728\u81e8\u5e8a\u6216\u8a3b\u518a\u968e\u6bb5THR\u03b2\u6fc0\u52d5\u5291\u7684\u986f\u8457\u5dee\u7570\u3002\u6211\u5011\u671f\u5f85\u5831\u544a\u9019\u9805\u7814\u7a76\u7b2c52\u5468\u809d\u7a7f\u6d3b\u6aa2\u7d44\u7e54\u5b78\u8a55\u4f30\u7d50\u679c\u3002\u300d\u6b4c\u79ae\u5275\u59cb\u4eba\u3001\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u57f7\u884c\u5b98\u5433\u52c1\u6893\u535a\u58eb\u8868\u793a\u3002<\/p>\n

\u7814\u7a76\u8a2d\u8a08<\/b>\u00a0<\/p>\n

\u8a72\u9805\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u5b89\u6170\u5291\u5c0d\u7167\u53ca\u591a\u4e2d\u5fc3\u7684II\u671f\u81e8\u5e8a\u8a66\u9a57\u65e8\u5728\u8a55\u4f30ASC41\u7247\u6cbb\u7642\u7d93\u809d\u7a7f\u6d3b\u6aa2\u8b49\u5be6\u7684NASH\u60a3\u8005\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u5165\u7d44\u5305\u62ec\u7d93MRI-PDFF\u8a55\u4f30\u57fa\u7dda\u809d\u81df\u8102\u80aa\u542b\u91cf\u70ba7.5%\u53ca\u4ee5\u4e0a\u7684\uff0c\u4ee5\u53ca\u809d\u81df\u7e96\u7dad\u5316\u70baF2\u548cF3\u7684\u60a3\u8005\u3002\u8a72\u7814\u7a76\u5141\u8a31\u5165\u7d44\u81f3\u591a15%\u7684\u809d\u81df\u7e96\u7dad\u5316\u70baF1\u7684\u60a3\u8005\u3002\u7d04180\u540d\u60a3\u8005\u5c07\u4ee51:1:1\u7684\u6bd4\u4f8b\u96a8\u6a5f\u5206\u914d\u9032\u5165\u5169\u500b\u6cbb\u7642\u968a\u5217\u548c\u4e00\u500b\u5b89\u6170\u5291\u5c0d\u7167\u968a\u5217\uff0c\u4e26\u63a5\u53d7\u4e00\u65e5\u4e00\u6b21\u53e3\u670dASC41\u7247\uff082\u6beb\u514b\u62164\u6beb\u514b\uff09\u6216\u5b89\u6170\u5291\uff0c\u6cbb\u764252\u5468\uff0c\u4e26\u96a8\u8a2a4\u5468\u3002\u5728\u57fa\u7dda\u548c52\u5468\u6cbb\u7642\u7d50\u675f\u6642\u5c07\u9032\u884c\u5169\u6b21\u809d\u7a7f\u6d3b\u6aa2\u3002\u5728\u57fa\u7dda\u3001\u7b2c12\u5468\u548c\u7b2c52\u5468\u5c07\u9032\u884cMRI-PDFF\u8a55\u4f30\u3002\u9810\u8a2d\u7684\u671f\u4e2d\u5206\u6790\u5c07\u5728\u7d0445\u540d\u5165\u7d44\u60a3\u8005\u5b8c\u621012\u5468\u7684ASC41\u7247\u6216\u5b89\u6170\u5291\u6cbb\u7642\u5f8c\u9032\u884c\u3002<\/p>\n

\u95dc\u65bc\u6b4c\u79ae<\/b><\/p>\n

\u6b4c\u79ae\u662f\u4e00\u5bb6\u5728\u9999\u6e2f\u8b49\u5238\u4ea4\u6613\u6240\u4e0a\u5e02\uff081672.HK\uff09\u7684\u5275\u65b0\u7814\u767c\u9a45\u52d5\u578b\u751f\u7269\u79d1\u6280\u516c\u53f8\uff0c\u6db5\u84cb\u4e86\u5f9e\u65b0\u85e5\u7814\u767c\u81f3\u751f\u7522\u548c\u5546\u696d\u5316\u7684\u5b8c\u6574\u50f9\u503c\u93c8\u3002\u6b4c\u79ae\u7684\u7ba1\u7406\u5718\u968a\u5177\u5099\u6df1\u539a\u7684\u5c08\u696d\u77e5\u8b58\u53ca\u512a\u79c0\u7684\u904e\u5f80\u6210\u5c31\uff0c\u5728\u5718\u968a\u7684\u5e36\u9818\u4e0b\uff0c\u6b4c\u79ae\u805a\u7126\u4e09\u5927\u81e8\u5e8a\u9700\u6c42\u5c1a\u672a\u6eff\u8db3\u7684\u91ab\u7642\u9818\u57df\uff1a\u75c5\u6bd2\u6027\u75be\u75c5\u3001\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e\u548c\u816b\u7624\uff0c\u4e26\u4ee5\u5168\u7403\u5316\u7684\u8996\u91ce\u9032\u884c\u4f48\u5c40\u3002\u6191\u501f\u5353\u8d8a\u7684\u57f7\u884c\u529b\uff0c\u6b4c\u79ae\u5feb\u901f\u63a8\u9032\u85e5\u7269\u7ba1\u7dda\u958b\u767c\uff0c\u722d\u53d6\u5728\u570b\u969b\u7af6\u722d\u4e2d\u4f54\u64da\u9818\u5148\u5730\u4f4d\u3002\u6b4c\u79ae\u76ee\u524d\u64c1\u6709\u591a\u6b3e\u5728\u7814\u85e5\u7269, \u6700\u524d\u6cbf\u7684\u5019\u9078\u85e5\u7269\u5305\u62ecASC22\uff08\u4e59\u809d\u529f\u80fd\u6027\u6cbb\u7652\uff09\u3001ASC40\uff08\u75e4\u7621\uff09\u3001ASC40\uff08\u5fa9\u767c\u6027\u81a0\u8cea\u6bcd\u7d30\u80de\u7624\uff09\u3001ASC40(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u3001ASC41(\u975e\u9152\u7cbe\u6027\u8102\u80aa\u6027\u809d\u708e)\u53caASC61\uff08\u665a\u671f\u5be6\u9ad4\u7624\uff09\u3002<\/p>\n

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