{"id":111207,"date":"2023-12-29T07:30:00","date_gmt":"2023-12-28T23:30:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=111207"},"modified":"2023-12-29T07:30:00","modified_gmt":"2023-12-28T23:30:00","slug":"%e4%b8%89%e8%91%89%e8%8d%89%e7%94%9f%e7%89%a9%e5%85%ac%e5%b8%83%e9%87%9d%e5%b0%8d%e8%85%ab%e7%98%a4%e5%8c%96%e7%99%82%e7%9b%b8%e9%97%9c%e6%80%a7%e8%a1%80%e5%b0%8f%e6%9d%bf%e6%b8%9b%e5%b0%91%e7%97%87","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=111207","title":{"rendered":"\u4e09\u8449\u8349\u751f\u7269\u516c\u5e03\u91dd\u5c0d\u816b\u7624\u5316\u7642\u76f8\u95dc\u6027\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7 (CIT) \u7684\u9776\u5411\u85e5\u7269SCB-219M \u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u7a4d\u6975\u6578\u64da"},"content":{"rendered":"
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\u2013\u6240\u6709 CIT \u60a3\u8005\uff08\u53d7\u8a66\u8005\uff09\u5728\u63a5\u53d7\u65b0\u4e00\u8f2a\u5316\u7642\u548c\u55ae\u6b21 SCB-219M \u7d66\u85e5\u5f8c 1 \u5468\uff0c\u8840\u5c0f\u677f\u8a08\u6578\u7dad\u6301\u5927\u65bc 75 x 109<\/sup>\/L\uff0c\u4e14\u7642\u6548\u6301\u7e8c\u81f3\u5c11 3 \u5468\u2013<\/i><\/p>\n

\u2013\u6301\u4e45\u7684\u7642\u6548\u548c PK \u6578\u64da\u6709\u671b\u652f\u6301\u22652 \u5468\u7684\u7d66\u85e5\u9593\u9694\uff0c\u9019\u8207\u76ee\u524d\u5728\u4e2d\u570b[1] <\/sup>\u548c\u5168\u7403\u8303\u570d\u5167[2]<\/sup>\u6bcf\u5929\u7d66\u85e5\u6216\u6bcf\u5468\u7d66\u85e5\u7684\u6a19\u51c6\u6cbb\u7642\u76f8\u8f03\u66f4\u70ba\u4fbf\u6377\u2013<\/i><\/p>\n

\u2013\u4e09\u8449\u8349\u751f\u7269\u8a08\u5283\u65bc 2024 \u5e74\u555f\u52d5\u91dd\u5c0d CIT \u548c CTIT\uff08\u816b\u7624\u6cbb\u7642\u5f15\u8d77\u7684\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7\uff09\u60a3\u8005\u7684\u91cd\u5fa9\u7d66\u85e5\u81e8\u5e8a\u2160b<\/span>\u671f\u8a66\u9a57\u2013<\/i><\/p>\n

\u6210\u90fd2023\u5e7412\u670829\u65e5 \/\u7f8e\u901a\u793e\/ \u2014 \u8655\u65bc\u5546\u696d\u5316\u968e\u6bb5\u7684\u5168\u7403\u751f\u7269\u5236\u85e5\u516c\u53f8\u2013\u4e09\u8449\u8349\u751f\u7269\u5236\u85e5\u6709\u9650\u516c\u53f8<\/a>\uff08\u4ee5\u4e0b\u7c21\u7a31\u300c\u4e09\u8449\u8349\u751f\u7269\u300d\uff1b \u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a02197\uff09\u4eca\u5929\u5ba3\u5e03\uff0c\u5728\u4e00\u9805\u8a55\u4f30\u4e00\u985e\u65b0\u85e5 SCB-219M \u7684\u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u4e2d\u7372\u5f97\u4e86\u7a4d\u6975\u7684\u5b89\u5168\u6027\u3001\u6709\u6548\u6027\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u521d\u6b65\u6578\u64da\uff0cSCB-219M\u662f\u901a\u904eCHO\u7d30\u80de\u751f\u7522\u7684\u4e00\u7a2e\u5275\u65b0\u578b\u5305\u542b\u8840\u5c0f\u677f\u751f\u6210\u7d20\u53d7\u9ad4\u6fc0\u52d5\u5291 (TPO-RA) \u6a21\u80bd\u7684\u96d9\u7279\u7570\u6027 Fc \u878d\u5408\u86cb\u767d\u9776\u5411\u85e5\u7269\uff0c\u7528\u65bc\u816b\u7624\u60a3\u8005\u5316\u7642\u5f15\u8d77\u7684\u8840\u5c0f\u677f\u6e1b\u5c11\u75c7 (CIT) \u3002<\/p>\n

\u8fc4\u4eca\u70ba\u6b62\uff0c\u6240\u6709\u63a5\u53d7\u5316\u7642\u548c\u76ae\u4e0b\u6ce8\u5c04\u55ae\u6b21SCB-219M\u7d66\u85e5\u7684\u816b\u7624\u60a3\u8005\uff089 \u4f8b\uff09\uff0c\u4e00\u5468\u5f8c\u5747\u89c0\u5bdf\u5230\u8840\u5c0f\u677f\u8a08\u6578\u53ef\u4fdd\u6301\u6216\u6062\u5fa9\u5230\u5927\u65bc 75 x 109<\/sup>\/L\uff08CIT\u8b66\u6212\u7dda\uff09\uff0c\u4e14\u7642\u6548\u81f3\u5c11\u6301\u7e8c\u4e09\u5468\uff0c\u81f3\u672c\u5316\u7642\u5468\u671f\u7d50\u675f\u3002\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u5728\u53c3\u52a0\u8a72\u81e8\u5e8a\u8a66\u9a57\u524d\uff0c\u540c\u6279\u816b\u7624\u60a3\u8005\u5728\u63a5\u53d7\u76f8\u540c\u7684\u5316\u7642\u5f8c\uff08\u4f46\u4e0d\u542bSCB-219M\u7d66\u85e5\uff09\uff0c\u8840\u5c0f\u677f\u8a08\u6578\u5728\u4e00\u5230\u4e09\u5468\u5167\u5747\u964d\u81f3\u5c0f\u65bc75 x 109<\/sup>\/L\u3002\u64da\u521d\u6b65\u7684\u89c0\u5bdf\uff0cSCB-219M\u6301\u4e45\u7684\u7642\u6548\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u5f81\u53ef\u80fd\u652f\u6301\u22652 \u5468\u7d66\u85e5\u7684\u9593\u9694\uff1b\u5982\u7814\u7a76\u7d50\u679c\u9032\u4e00\u6b65\u88ab\u9a57\u8b49\uff0cSCB-219M\u5c31\u80fd\u914d\u5408\u5316\u7642\u7642\u7a0b\u5be6\u73fe\u540c\u6b65\u7d66\u85e5\uff08\u4e00\u500b\u5316\u7642\u5468\u671f\u901a\u5e38\u70ba2-3\u5468\uff09\uff0c\u9019\u6a23\u4fdd\u8b49\u7642\u6548\u7684\u540c\u6642\u7d66\u4e88\u816b\u7624\u60a3\u8005\u66f4\u5927\u7684\u4fbf\u5229\u3002\u76ee\u524d\u81e8\u5e8a\u6578\u64da\u986f\u793aSCB-219M\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u6c92\u6709\u89c0\u5bdf\u5230\u4efb\u4f55\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6 (SAEs) \u548c\u5291\u91cf\u9650\u5236\u6027\u6bd2\u6027 (DLT)\u3002<\/p>\n

\u56db\u5ddd\u5927\u5b78\u83ef\u897f\u91ab\u9662\u816b\u7624\u4e2d\u5fc3\u526f\u4e3b\u4efb\u3001<\/b>SCB-219M \u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u9996\u5e2d\u7814\u7a76\u54e1\u738b\u6c38\u751f\u6559\u6388<\/b>\u8a8d\u70ba\uff1a\u300c\u8fc4\u4eca\u70ba\u6b62SCB-219M \u7684\u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u7d50\u679c\u4ee4\u4eba\u9f13\u821e\uff0c\u6211\u5011\u671f\u5f85\u5c0dSCB-219M\u9032\u884c\u5f8c\u7e8c\u8a55\u4f30\uff0c\u5c0d\u65bc\u63a5\u53d7\u6297\u816b\u7624\u6cbb\u7642\u7684\u60a3\u8005\u4f86\u8aaa\uff0cCIT \u7684\u9ad8\u6548\u81e8\u5e8a\u7ba1\u7406\u4ecd\u7136\u662f\u4e00\u500b\u975e\u5e38\u91cd\u8981\u7684\u81e8\u5e8a\u9700\u6c42\u3002\u300d<\/p>\n

\u300c\u6211\u5011\u5f88\u9ad8\u8208\u5730\u516c\u5e03\uff0cSCB-219M \u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u6578\u64da\u986f\u793a\u51fa\u5176\u5feb\u901f\u800c\u6301\u4e45\u7684\u7642\u6548\u53ca\u826f\u597d\u7684\u5b89\u5168\u6027\u6578\u64da\u3002\u300d\u4e09\u8449\u8349\u751f\u7269\u8463\u4e8b\u9577\u517c\u9996\u5e2d\u79d1\u5b78\u5b98\u3001SCB-219M\u7684\u767c\u660e\u4eba\u6881\u670b\u535a\u58eb\u8868\u793a<\/b>\uff0c\u300c\u521d\u6b65\u6578\u64da\u8868\u660e\uff0c\u8207\u4e2d\u570b\u548c\u5168\u7403\u76ee\u524d\u6cbb\u7642CIT\u548cCTIT\u7684\u6a19\u51c6\u7642\u6cd5\u76f8\u6bd4\uff0cSCB-219M\u5177\u6709\u6f5b\u5728\u7684\u5dee\u7570\u5316\u7279\u5f81\u3002\u4e2d\u570b\u76ee\u524d\u6cbb\u7642CIT\u7684\u6a19\u51c6\u751f\u7269\u7642\u6cd5\u9700\u8981\u6bcf\u5929\u6ce8\u5c04\u7d66\u85e5[1]<\/sup>\uff0c\u800c\u5728\u5168\u7403\u76ee\u524d\u6cbb\u7642CIT\u7684\u6a19\u51c6\u751f\u7269\u7642\u6cd5\u9700\u8981\u6bcf\u5468\u6ce8\u5c04\u7d66\u85e5[2]<\/sup>\uff0c\u76f8\u6bd4\u4e4b\u4e0b\uff0c\u8fc4\u4eca\u70ba\u6b62\u89c0\u5bdf\u5230SCB-219M\u7684\u6301\u4e45\u7642\u6548\u548c\u85e5\u4ee3\u52d5\u529b\u5b78\u7279\u6027\u4f7f\u5176\u6f5b\u5728\u53ef\u652f\u6301\u22652 \u5468\u7d66\u85e5\u9593\u9694\uff0c\u8b93\u914d\u5408\u5316\u7642\u7642\u7a0b\u5be6\u73fe\u540c\u6b65\u7d66\u85e5\u6210\u70ba\u53ef\u80fd\uff0c\u7d66\u60a3\u8005\u63d0\u4f9b\u65b9\u4fbf\u548c\u4fdd\u8b77\u3002\u300d<\/p>\n

\u672c\u9805\u2160\u671f\u81e8\u5e8a\u8a66\u9a57\u662f\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u958b\u653e\u6027\u3001\u5291\u91cf\u722c\u5761\u548c\u5291\u91cf\u64f4\u589e\u7684\u7814\u7a76\uff0c\u63a2\u7d22SCB-219M\u7d93\u76ae\u4e0b\u6ce8\u5c04\u5728CIT\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u3001\u8010\u53d7\u6027\u3001\u514d\u75ab\u539f\u6027\u3001\u85e5\u7269\u52d5\u529b\u5b78\u7279\u5f81\u53ca\u6709\u6548\u6027\u3002\u53c3\u52a0\u672c\u81e8\u5e8a\u8a66\u9a57\u7684\u7814\u7a76\u4e2d\u5fc3\u5305\u62ec\u56db\u5ddd\u5927\u5b78\u83ef\u897f\u91ab\u9662\u816b\u7624\u4e2d\u5fc3\uff0c\u56db\u5ddd\u7701\u4eba\u6c11\u91ab\u9662\u548c\u6210\u90fd\u5e02\u7b2c\u516d\u4eba\u6c11\u91ab\u9662\u3002\u4e09\u8449\u8349\u751f\u7269\u8a08\u5283\u65bc 2024 \u5e74\u555f\u52d5\u2160b\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u8a55\u4f30SCB-219M\u5728CIT\u548cCTIT\u60a3\u8005\u4e2d\u91cd\u5fa9\u7d66\u85e5\u7684\u60c5\u6cc1\u3002<\/p>\n

CIT\u662f\u4e00\u7a2e\u56b4\u91cd\u7684\u3001\u5316\u7642\u5f15\u8d77\u7684\u4e26\u767c\u75c7\uff0c\u53ef\u5ee3\u6cdb\u51fa\u73fe\u65bc\u816b\u7624\u60a3\u8005\u4e2d\u3002\u5728\u63a5\u53d7\u6a19\u51c6\u5316\u7642\u65b9\u6848\u7684\u60a3\u8005\u4e2d\uff0cCIT\u7684\u767c\u751f\u7387\u53ef\u8d85\u904e50%[3]<\/sup>\uff0c\u4e26\u6703\u5c0d\u6cbb\u7642\u7d50\u679c\u7522\u751f\u56b4\u91cd\u4e0d\u5229\u5f71\u97ff\uff0c\u5c0e\u81f4\u5316\u7642\u6642\u9593\u5ef6\u9072\u6216\u5316\u7642\u5291\u91cf\u6e1b\u5c11\uff0c\u4ee5\u53ca\u6f5b\u5728\u7684\u81f4\u547d\u6027\u51fa\u8840\u4e8b\u4ef6\u3002<\/p>\n

\n\n\n\n\n\n
\n

1. TPIAO (3SBio; https:\/\/ypk.39.net\/666055\/manual).<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

2. Nplate; romiplostim (https:\/\/doi.org\/10.3324\/haematol.2020.251900; https:\/\/doi.org\/10.1200\/JCO.18.01931<\/a>).<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

3. Ying Wu, Suresh Aravind, Gayatri Ranganathan, et al. Anemia and thrombocytopenia in patients undergoing chemotherapy for solid tumors: A descriptive study of a large outpatient oncology practice database, 2000\u2013 2007[J]. Clinical Therapeutics, Volume 31, Part 2,2009, Pages 2416-2432\u00a0<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n

\u00a0<\/p>\n

\u95dc\u65bc\u4e09\u8449\u8349\u751f\u7269<\/b>\u00a0<\/p>\n

\u4e09\u8449\u8349\u751f\u7269\u662f\u4e00\u5bb6\u8655\u65bc\u5546\u696d\u5316\u968e\u6bb5\u7684\u5168\u7403\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u81f4\u529b\u4ee5\u5275\u65b0\u578b\u75ab\u82d7\u53ca\u751f\u7269\u5236\u85e5\u62ef\u6551\u751f\u547d\u548c\u6539\u5584\u5168\u7403\u5065\u5eb7\u6c34\u5e73\u3002 \u6191\u501f\u7d9c\u5408\u7814\u767c\u5be6\u529b\u3001\u751f\u7522\u548c\u5546\u696d\u5316\u80fd\u529b\uff0c\u4ee5\u53ca\u8207\u5206\u5e03\u5168\u7403\u7684\u76f8\u95dc\u6a5f\u69cb\u5f37\u5927\u7684\u5408\u4f5c\u4f19\u4f34\u95dc\u7cfb\uff0c\u6211\u5011\u5df2\u7d93\u958b\u767c\u51fa\u591a\u6a23\u5316\u7684\u5019\u9078\u75ab\u82d7\u7ba1\u7dda\uff0c\u4ee5\u671f\u6211\u5011\u7684\u75ab\u82d7\u53ef\u4f7f\u66f4\u591a\u75be\u75c5\u5f97\u5230\u9810\u9632\uff0c\u52a9\u529b\u6e1b\u8f15\u516c\u5171\u885b\u751f\u7684\u8ca0\u64d4\u3002\u00a0\u00a0\u00a0\u00a0<\/p>\n

\u4e09\u8449\u8349\u751f\u7269\u524d\u77bb\u6027\u8072\u660e<\/b>\u00a0<\/p>\n

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