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\u65bd\u7dad\u96c5\u4e2d\u570b\u5340\u7e3d\u7d93\u7406<\/b>Manuel RUIZ<\/b>\u8868\u793a\uff1a\u300c<\/span> <\/b>\u6211\u5011\u5c0d\u65bc\u5c07\u62d3\u8212\u6c83\u00ae<\/sup>\u7d0d\u5165\u65bd\u7dad\u96c5\u4e2d\u570b\u7684\u7522\u54c1\u7ba1\u7dda\u611f\u5230\u9a55\u50b2\u548c\u8208\u596e\u3002\u4f5c\u70ba\u9996\u500b\u4e14\u552f\u4e00\u7372\u6279\u7684\u9776\u5411\u7642\u6cd5\uff0c\u62d3\u8212\u6c83\u00ae<\/sup>\u5c07\u70ba\u651c\u5e36IDH1\u7a81\u8b8a\u7684\u5fa9\u767c\u6216\u96e3\u6cbb\u6027\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\uff08AML\uff09\u60a3\u8005\u5e36\u4f86\u65b0\u7684\u89e3\u6c7a\u65b9\u6848\uff0c\u5f37\u5316\u65bd\u7dad\u96c5\u5728IDH1\u7a81\u8b8a\u65b9\u9762\u7684\u9818\u5148\u512a\u52e2\uff0c\u4e26\u9032\u4e00\u6b65\u592f\u5be6\u6211\u5011\u70ba\u4e2d\u570b\u96e3\u6cbb\u6027\u764c\u75c7\u60a3\u8005\u63d0\u4f9b\u5275\u65b0\u6cbb\u7642\u65b9\u6848\u7684\u627f\u8afe\u3002\u300d<\/span>\u00a0<\/p>\n

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AML\u662f\u6210\u4eba\u6025\u6027\u767d\u8840\u75c5\u4e2d\u6700\u5e38\u898b\u7684\u985e\u578b\uff0c\u6b50\u6d32\u5e74\u767c\u75c5\u7387\u7d04\u70ba5\/100,000\u4eba\uff0c\u5373\u6bcf\u5e74\u6709\u8d85\u904e2\u842c\u4f8b\u65b0\u767c\u75c5\u4f8b[5]\u300275\u6b72\u60a3\u8005\u7684\u5169\u5e74\u751f\u5b58\u7387\u4f4e\u65bc10%[6]\u3002<\/p>\n

\u5728\u4e2d\u570b\uff0cAML\u5728\u6bcf\u5e74\u65b0\u8a3a\u65b7\u764c\u75c7\u75c5\u4f8b\u4e2d\u53601%\uff0c\u7d04\u5360\u6240\u6709\u767d\u8840\u75c5\u8a3a\u65b7\u75c5\u4f8b\u7684\u4e00\u534a\uff0c\u6bcf\u5e74\u5c0e\u81f422000\u4eba\u6b7b\u4ea1\u3002[7]<\/p>\n

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\u9019\u7a2e\u764c\u75c7\u7531\u4e00\u7a2e\u672a\u6210\u719f\u7d30\u80de\u7684\u7570\u5e38\u589e\u6b96\u5c0e\u81f4\uff0c\u9019\u4e9b\u7d30\u80de\u6c92\u6709\u5b8c\u5168\u767c\u80b2\uff0c\u56e0\u6b64\u7121\u6cd5\u767c\u63ee\u5176\u6b63\u5e38\u4f5c\u7528\u3002\u9019\u4e9b\u764c\u7d30\u80de\u5b58\u5728\u65bc\u8840\u6db2\u4e2d\uff0c\u56e0\u6b64\u88ab\u7a31\u70ba\u300c<\/span> \u767d\u8840\u75c5\u300d<\/span> \uff1b\u800c\u56e0\u70ba\u5b83\u5011\u8d77\u6e90\u65bc\u9aa8\u9ad3\uff0c\u56e0\u6b64\u88ab\u7a31\u70ba\u300c<\/span> \u9ad3\u7cfb\u300d<\/span> \u3002\u9aa8\u9ad3\u662f\u4eba\u9ad4\u9aa8\u9abc\u4e2d\u7684\u4e00\u7a2e\u7d44\u7e54\uff0c\u662f\u7522\u751f\u8840\u7d30\u80de\uff08\u7a31\u70ba\u300c<\/span> \u6bcd\u7d30\u80de\u300d<\/span> \uff09\u7684\u91cd\u8981\u7d44\u7e54\u3002<\/p>\n

\u95dc\u65bc\u65bd\u7dad\u96c5\u4e2d\u570b<\/b><\/p>\n

\u65bd\u7dad\u96c5\u662f\u4e00\u5bb6\u7531\u57fa\u91d1\u6703\u7ba1\u7406\u7684\u5168\u7403\u6027\u88fd\u85e5\u96c6\u5718\uff0c\u4ee5\u670d\u52d9\u4eba\u985e\u5065\u5eb7\u70ba\u5b97\u65e8\uff0c\u671f\u671b\u70ba\u60a3\u8005\u548c\u4e16\u754c\u53ef\u6301\u7e8c\u767c\u5c55\u5e36\u4f86\u610f\u7fa9\u6df1\u9060\u7684\u793e\u6703\u5f71\u97ff\u3002\u4f5c\u70ba\u9996\u6279\u9032\u5165\u4e2d\u570b\u7684\u8de8\u570b\u88fd\u85e5\u4f01\u696d\u4e4b\u4e00\uff0c\u65bd\u7dad\u96c5\u5df2\u6df1\u8015\u4e2d\u570b\u5e02\u583445\u5e74\u3002\u7d93\u904e\u5e7e\u5341\u5e74\u7684\u7a4d\u7d2f\u6c89\u6fb1\uff0c\u65bd\u7dad\u96c5\u4e2d\u570b\u5df2\u7d93\u6210\u70ba\u4e00\u5bb6\u5145\u6eff\u6d3b\u529b\u7684\u516c\u53f8\uff0c\u5728\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u3001\u975c\u8108\u75be\u75c5\u7ba1\u7406\u65b9\u9762\u5c45\u65bc\u9818\u5148\u5730\u4f4d\u7684\u540c\u6642\uff0c\u7a4d\u6975\u62d3\u5c55\u816b\u7624\u5b78\u9818\u57df\uff0c\u5982\u7d50\u76f4\u8178\u764c\u3001\u81a0\u8cea\u7624\u548c\u6db2\u9ad4\u816b\u7624\u3002\u65bd\u7dad\u96c5\u81f4\u529b\u65bc\u70ba\u66f4\u591a\u4e2d\u570b\u60a3\u8005\u63d0\u4f9b\u9776\u5411\u6cbb\u7642\u85e5\u7269\u548c\u89e3\u6c7a\u65b9\u6848\u3002\u65bd\u7dad\u96c5\u4e2d\u570b\u7e3d\u90e8\u4f4d\u65bc\u5317\u4eac\uff0c\u64c1\u6709\u4e00\u652f\u8d85\u904e1000\u4eba\u7684\u5f37\u5927\u5c08\u696d\u5718\u968a\u3002<\/p>\n

\u6b32\u77ad\u89e3\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u8a2a\u554fservier.com.cn<\/a>\u202f \u202f<\/p>\n

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[1]\u00a0FDA News Release: https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-first-targeted-treatment-patients-relapsed-or-refractory-acute-myeloid-leukemia-who<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[2]\u00a0\u6839\u64da\u570b\u5bb6\u764c\u75c7\u4e2d\u5fc3\u300a2016\u5e74\u4e2d\u570b\u764c\u75c7\u767c\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u300b\u7d71\u8a08\u6578\u64da<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[3]\u00a0\u674e\u96c5,\u9673\u745c,\u674e\u8ecd\u6c11.\u8001\u5e74\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u7684\u6cbb\u7642\u9032\u5c55[J].\u5167\u79d1\u7406\u8ad6\u8207\u5be6\u8e10,2019,14(06): 391-394.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[4]\u00a0\u65b0\u82f1\u683c\u862d\u91ab\u5b78\u96dc\u8a8c\uff0c2018\u5e74\uff0c378\uff0825\uff09\uff1a2386-2398<\/span><\/p>\n<\/td>\n<\/tr>\n

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[5]\u00a0ESMO Guidelines 2020 \u2013 Acute myeloid leukemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up<\/span><\/p>\n<\/td>\n<\/tr>\n

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[6]\u00a0National Cancer Institute. Surveillance, Epidemiology, and End Results (SEER) Program. Cancer Stat Facts: Acute Myeloid Leukemia (AML). https:\/\/seer.cancer.gov\/statfacts\/html\/amyl.html<\/span><\/p>\n<\/td>\n<\/tr>\n

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[7]\u00a0\u674e\u96c5,\u9673\u745c,\u674e\u8ecd\u6c11.\u8001\u5e74\u6025\u6027\u9ad3\u7cfb\u767d\u8840\u75c5\u7684\u6cbb\u7642\u9032\u5c55[J].\u5167\u79d1\u7406\u8ad6\u8207\u5be6\u8e10,2019,14(06): 391-394.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

[8]\u00a0By National Cancer Center, 2022 National Cancer Report (phirda.com)<\/span><\/p>\n<\/td>\n<\/tr>\n

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[9]\u00a0GLOBOCAN Cancer Today Database, International Agency for Research on Cancer, World Health Organisation.Population Fact Sheets in 2018. Available at: http:\/\/gco.iarc.fr\/today\/data\/factsheets\/populations\/160-china-factsheets.pdf. Last accessed March 2020.<\/span><\/p>\n<\/td>\n<\/tr>\n

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[10] https:\/\/www.cancer.org\/cancer\/acute-myeloid-leukemia\/about\/key-satatist<\/a><\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<\/div>\n

\n\u65b0\u805e\u4f86\u6e90\uff1aPR Newswire<\/p>\n

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