{"id":107581,"date":"2023-12-18T08:00:00","date_gmt":"2023-12-18T00:00:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=107581"},"modified":"2023-12-18T08:00:00","modified_gmt":"2023-12-18T00:00:00","slug":"nature-communications-%e7%99%bc%e8%a1%a8%e7%91%aa%e4%bb%95%e5%ba%a6%e8%82%bd-ibi362-%e5%9c%a8%e4%b8%ad%e5%9c%8b%e8%b6%85%e9%87%8d%e6%88%96%e8%82%a5%e8%83%96%e5%8f%97%e8%a9%a6%e8%80%85%e4%b8%ad","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=107581","title":{"rendered":"Nature Communications \u767c\u8868\u746a\u4ed5\u5ea6\u80bd (IBI362) \u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u7684II\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5168\u6587"},"content":{"rendered":"<div>\n<div>\n<p><span class=\"legendSpanClass\">\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2023\u5e7412\u670818\u65e5<\/span> <span>\/\u7f8e\u901a\u793e\/ \u2014 \u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\uff08\u9999\u6e2f\u806f\u4ea4\u6240\u80a1\u7968\u4ee3\u78bc\uff1a<\/span><span>01801<\/span><span>\uff09\uff0c\u4e00\u5bb6\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u5275\u65b0\u85e5\u7269\u7684\u751f\u7269\u88fd\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u4f48\uff1a\u65b0\u4e00\u4ee3\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd<\/span><span>-1<\/span><span>\u53d7\u9ad4\uff08<\/span><span>glucagon-like peptide-1 receptor, GLP-1R<\/span><span>\uff09<\/span><span>\/<\/span><span>\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4\uff08<\/span><span>glucagon receptor, GCGR<\/span><span>\uff09\u96d9\u91cd\u6fc0\u52d5\u5291\u746a\u4ed5\u5ea6\u80bd\uff08\u7814\u767c\u4ee3\u865f\uff1a<\/span><span>IBI362<\/span><span>\uff09\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u7684<\/span><span>II<\/span><span>\u671f\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5168\u6587\u8fd1\u65e5\u5728\u570b\u969b\u77e5\u540d\u671f\u520a<\/span><span><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-44067-4\" target=\"_blank\" rel=\"nofollow noopener\"><i>Nature Communications<\/i><span>\u5728\u7dda\u767c\u8868<\/span><\/a><\/span><span>\u3002\u5317\u5927\u4eba\u6c11\u91ab\u9662\u7d00\u7acb\u8fb2\u6559\u6388\uff0c\u6cb3\u5357\u79d1\u6280\u5927\u5b78\u4e00\u9644\u9662\u59dc\u5b8f\u885b\u6559\u6388\u7b49\u56db\u4f4d\u7814\u7a76\u8005\u70ba\u4e26\u5217\u7b2c\u4e00\u4f5c\u8005\uff1b\u7d00\u7acb\u8fb2\u6559\u6388\u8207\u4fe1\u9054\u751f\u7269\u9322\u9433\u70ba\u4e26\u5217\u901a\u8a0a\u4f5c\u8005<\/span><span>\u3002<\/span><\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder8552\">\n<p style=\"TEXT-ALIGN: center; WIDTH: 100%\"><span>\u4f5c\u70ba\u5168\u7403\u540c\u985e\u9996\u5275\u7684\u65b0\u4e00\u4ee3GLP-1R\/GCGR\u96d9\u91cd\u6fc0\u52d5\u5291\uff0c\u746a\u4ed5\u5ea6\u80bd\u7528\u65bc\u6cbb\u7642\u80a5\u80d6\/\u8d85\u91cd\u53ca2\u578b\u7cd6\u5c3f\u75c5\u7684\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u5df2\u767c\u8868\u5728\u5168\u7403\u6838\u5fc3\u671f\u520a\u96dc\u8a8c\uff0c\u5305\u62eceClinicalMedicine, Nature Communications, \u53caDiabetes Care.<\/span><\/p>\n<\/div>\n<p><b><span>\u672c\u6587\u901a\u8a0a\u4f5c\u8005\uff0c\u66a8\u672c\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5317\u4eac\u5927\u5b78\u4eba\u6c11\u91ab\u9662\u7d00\u7acb\u8fb2\u6559\u6388<\/span><\/b><span>\u8868\u793a\uff1a\u300c\u80a5\u80d6\u662f\u4e00\u9805\u6210\u56e0\u8907\u96dc\u7684\u6162\u6027\u4ee3\u8b1d\u6027\u75be\u75c5\uff0c\u662f\u7cd6\u5c3f\u75c5\u3001\u8102\u80aa\u809d\u3001\u5fc3\u8166\u8840\u7ba1\u75be\u75c5\u3001\u95dc\u7bc0\u75be\u75c5\u3001\u547c\u5438\u7761\u7720\u969c\u7919\u548c\u764c\u75c7\u7b49\u4e00\u7cfb\u5217\u7684\u91cd\u8981\u75c5\u56e0\u6216\u5371\u96aa\u56e0\u7d20\uff0c\u9700\u8981\u5f15\u8d77\u5168\u793e\u6703\u7684\u9ad8\u5ea6\u91cd\u8996\uff0c\u5171\u540c\u63d0\u5021\u79d1\u5b78\u6709\u6548\u7684\u7d9c\u5408\u8a3a\u6cbb\u548c\u9577\u671f\u9ad4\u91cd\u7ba1\u7406\u3002\u4e2d\u570b\u80a5\u80d6\u4eba\u6578\u5c45\u5168\u7403\u4e4b\u9996\uff0c\u800c\u76ee\u524d\u5c1a\u6c92\u6709\u5b89\u5168\u4e14\u5341\u5206\u6709\u6548\u7684\u85e5\u7269\u7642\u6cd5\u7372\u6279\u6e1b\u91cd\u9069\u61c9\u75c7\u3002\u5f88\u9ad8\u8208\u746a\u4ed5\u5ea6\u80bd\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d\u7684<\/span><span>II<\/span><span>\u671f\u7814\u7a76\u7684\u7d50\u679c\u88ab<\/span><i><span>Nature Communications<\/span><\/i><span>\u63a5\u53d7\u4e26\u5168\u6587\u767c\u8868\u3002\u8a72\u7814\u7a76\u7d50\u679c\u5c55\u73fe\u4e86\u746a\u4ed5\u5ea6\u80bd\u4f5c\u70ba\u65b0\u4e00\u4ee3<\/span><span>GLP-1R\/GCGR<\/span><span>\u96d9\u91cd\u6fc0\u52d5\u5291\u512a\u7570\u7684\u81e8\u5e8a\u7279\u5fb5\u3002\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u70ba\u53d7\u8a66\u8005\u7684\u7528\u85e5\u4f9d\u5f9e\u63d0\u4f9b\u4e86\u4fdd\u969c\uff0c\u4e26\u5be6\u73fe\u4e86\u5f37\u52c1\u7684\u6e1b\u91cd\u7642\u6548\u548c\u5305\u62ec\u8170\u570d\uff0c\u8840\u58d3\uff0c\u8840\u8102\u3001\u809d\u9176\u548c\u8840\u5c3f\u9178\u5728\u5167\u7684\u591a\u91cd\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u7372\u76ca\u3002\u671f\u5f85\u746a\u4ed5\u5ea6\u80bd\u5728\u8a3b\u518a\u81e8\u5e8a<\/span><span>III<\/span><span>\u671f\u7814\u7a76\u80fd\u9032\u4e00\u6b65\u7372\u5f97\u5f97\u78ba\u8b49\u6027\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u7684\u7d50\u679c\uff0c\u65e9\u65e5\u70ba\u6211\u570b\u8d85\u91cd\u548c\u80a5\u80d6\u7684\u53d7\u8a66\u8005\u5e36\u4f86\u7a81\u7834\u6027\u7684\u6cbb\u7642\u9078\u64c7\u3002<\/span><span>\u300d<\/span><\/p>\n<p><b><span>\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u81e8\u5e8a\u526f\u7e3d\u88c1\u9322\u9433\u535a\u58eb<\/span><\/b><span>\u8868\u793a\uff1a\u300c\u746a\u4ed5\u5ea6\u80bd\u662f\u5168\u7403\u540c\u985e\u9996\u5275\u7684\u65b0\u4e00\u4ee3<\/span><span>GLP-1R\/GCGR<\/span><span>\u96d9\u91cd\u6fc0\u52d5\u5291\u3002\u672c\u9805<\/span><span>II<\/span><span>\u671f\u7814\u7a76\u7d50\u679c\u8868\u660e\uff0c\u5728\u5b89\u5168\u6027\u826f\u597d\u7684\u524d\u63d0\u4e0b\uff0c\u746a\u4ed5\u5ea6\u80bd\u7684\u6e1b\u91cd\u6548\u679c\u5feb\u901f\u4e14\u5f37\u52c1\uff0c\u4e26\u5e36\u4f86\u5168\u9762\u7684\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u7d9c\u5408\u7372\u76ca\uff0c\u9032\u4e00\u6b65\u986f\u793a\u4e86\u76f8\u8f03<\/span><span>GLP-1R<\/span><span>\u55ae\u9776\u85e5\u7269\u7684\u6f5b\u5728\u5dee\u7570\u5316\u512a\u52e2\u3002\u76ee\u524d\uff0c\u746a\u4ed5\u5ea6\u80bd<\/span><span>4 mg<\/span><span>\u548c<\/span><span>6 mg<\/span><span>\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u53d7\u8a66\u8005\u4e2d<\/span><span>III<\/span><span>\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\uff08<\/span><span>GLORY-1<\/span><span>\uff09\u6b63\u5728\u9032\u884c\u4e2d\uff0c\u8a72\u7814\u7a76\u5c07\u63d0\u4f9b\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\u4eba\u7fa4\u4e2d\u7684\u5927\u6a23\u672c\u91cf\u6e1b\u91cd\u7814\u7a76\u91ab\u5b78\u8b49\u64da\u3002\u746a\u4ed5\u5ea6\u80bd\u9ad8\u5291\u91cf<\/span><span>9 mg<\/span><span>\u7528\u65bc\u4e2d\u91cd\u5ea6\u80a5\u80d6\u4eba\u7fa4\u7684<\/span><span>III<\/span><span>\u671f\u8a3b\u518a\u81e8\u5e8a\u7814\u7a76\u4e5f\u5df2\u555f\u52d5\u3002\u6211\u5011\u5e0c\u671b\u9019\u6b3e\u9ad8\u8cea\u91cf\u85e5\u7269\u65e9\u65e5\u60e0\u53ca\u4e2d\u570b\u5ee3\u5927\u8d85\u91cd\u548c\u80a5\u80d6\u60a3\u8005\uff0c\u4e26\u901a\u904e\u500b\u6027\u5316\u7684\u65b9\u6848\u70ba\u4e0d\u540c\u7a0b\u5ea6\u80a5\u80d6\u4eba\u7fa4\u5e36\u4f86\u66f4\u597d\u7684\u7372\u76ca\u3002<\/span><span>\u300d<\/span><\/p>\n<p><span>\u672c\u6587\u7ae0\u767c\u8868\u7684\u7814\u7a76\u7d50\u679c\u4f86\u81ea\u4e00\u9805\u591a\u4e2d\u5fc3\u3001\u96d9\u76f2\u3001\u96a8\u6a5f\u3001\u5b89\u6170\u5291\u5c0d\u7167\u7684<\/span><span>II<\/span><span>\u671f\u81e8\u5e8a\u7814\u7a76\uff08<\/span><span>ClinicalTrials.gov, NCT04904913<\/span><span>\uff09\u7b2c\u4e00\u968e\u6bb5\u7684\u7d50\u679c\uff08\u8a72\u7814\u7a76\u7b2c\u4e00\u968e\u6bb5\u70ba<\/span><span>3.0 mg<\/span><span>\u3001<\/span><span>4.5 mg<\/span><span>\u548c<\/span><span>6.0 mg<\/span><span>\u968a\u5217\uff0c\u7b2c\u4e8c\u968e\u6bb5\u70ba<\/span><span>9mg <\/span><span>\u968a\u5217\uff09\u3002\u7814\u7a76\u7b2c\u4e00\u968e\u6bb5\u5171\u5165\u7d44<\/span><span>248<\/span><span>\u4f8b\u80a5\u80d6\uff08<\/span><span>BMI\u226528.0 kg\/m<sup>2<\/sup><\/span><span>\uff09\u6216\u8d85\u91cd\uff08<\/span><span>24.0 kg\/m<sup>2<\/sup>\u2264 BMI <\/span><span>\uff1c<\/span><span>28.0 kg\/m<sup>2<\/sup><\/span><span>\uff09\u4e26\u4f34\u6709\u81f3\u5c11\u4e00\u7a2e\u80a5\u80d6\u76f8\u95dc\u4f75\u767c\u75c7\u7684\u53d7\u8a66\u8005\uff0c\u96a8\u6a5f\u63a5\u53d7\u746a\u4ed5\u5ea6\u80bd<\/span><span> 3 mg<\/span><span>\u3001<\/span><span>4.5 mg<\/span><span>\u3001<\/span><span>6 mg<\/span><span>\u6216\u5b89\u6170\u5291\uff0c\u6bcf\u9031\u4e00\u6b21\u3001\u76ae\u4e0b\u6ce8\u5c04\u7d66\u85e5<\/span><span>24<\/span><span>\u5468\u3002\u7814\u7a76\u4e3b\u8981\u7d42\u9ede\u70ba\u7b2c<\/span><span>24<\/span><span>\u5468\u6642\u9ad4\u91cd\u8f03\u57fa\u7dda\u7684\u767e\u5206\u6bd4\u8b8a\u5316\u3002\u53d7\u8a66\u8005\u57fa\u7dda\u5e73\u5747\u9ad4\u91cd\u70ba<\/span><span>89.4 kg<\/span><span>\uff0c\u57fa\u7dda\u5e73\u5747<\/span><span>BMI<\/span><span>\u70ba<\/span><span>31.8 kg\/m<sup>2<\/sup><\/span><span>\u3002<\/span><\/p>\n<p><b><span>\u7814\u7a76\u7d50\u679c\u986f\u793a\uff0c\u8207\u5b89\u6170\u5291\u76f8\u6bd4\uff0c\u5404\u5291\u91cf\u746a\u4ed5\u5ea6\u80bd\u5747\u53ef\u986f\u8457\u964d\u4f4e\u9ad4\u91cd<\/span><\/b><b><span>\u3002<\/span><\/b><\/p>\n<ul type=\"disc\">\n<li><span>\u7b2c<\/span><span>24<\/span><span>\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd<\/span><span>3 mg<\/span><span>\u3001<\/span><span>4.5 mg<\/span><span>\u548c<\/span><span>6 mg<\/span><span>\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u767e\u5206\u6bd4\u8b8a\u5316\u5747\u503c\u70ba<\/span><span>-6.7%<\/span><span>\u3001<\/span><span>-10.4%<\/span><span>\u548c<\/span><span>-11.3%<\/span><span>\uff0c\u5b89\u6170\u5291\u7d44\u70ba<\/span><span>1.0%<\/span><span>\u3002\u746a\u4ed5\u5ea6\u80bd<\/span><span>3 mg<\/span><span>\u3001<\/span><span>4.5 mg<\/span><span>\u548c<\/span><span>6 mg<\/span><span>\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u767e\u5206\u6bd4\u8b8a\u5316\u8207\u5b89\u6170\u5291\u7d44\u7684\u5dee\u503c\u5206\u5225\u70ba<\/span><span>-7.7%<\/span><span>\u3001<\/span><span>-11.4%<\/span><span>\u548c<\/span><span>-12.3%<\/span><span>\u3002<\/span><\/li>\n<li><span>\u7b2c<\/span><span>24<\/span><span>\u5468\u6642\uff0c\u746a\u4ed5\u5ea6\u80bd<\/span><span>3 mg<\/span><span>\u3001<\/span><span>4.5 mg<\/span><span>\u548c<\/span><span>6 mg<\/span><span>\u7d44\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45<\/span><span>\u22655.0%<\/span><span>\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u9054<\/span><span>58.1%<\/span><span>\u3001<\/span><span>82.5%<\/span><span>\u548c<\/span><span>80.3%<\/span><span>\uff0c\u5b89\u6170\u5291\u7d44\u70ba<\/span><span>4.8%<\/span><span>\uff1b\u9ad4\u91cd\u8f03\u57fa\u7dda\u964d\u5e45<\/span><span>\u226510.0%<\/span><span>\u7684\u53d7\u8a66\u8005\u6bd4\u4f8b\u5206\u5225\u9054<\/span><span>19.4%<\/span><span>\u3001<\/span><span>49.2%<\/span><span>\u548c<\/span><span>50.8%<\/span><span>\uff0c\u5b89\u6170\u5291\u7d44\u70ba<\/span><span>0<\/span><span>\u3002<\/span><\/li>\n<\/ul>\n<p><b><span>\u746a\u4ed5\u5ea6\u80bd\u7e3d\u9ad4\u8010\u53d7\u6027\u548c\u5b89\u5168\u6027\u826f\u597d<\/span><\/b><b><span>\u3002<\/span><\/b><\/p>\n<ul type=\"disc\">\n<li><span>\u7814\u7a76\u671f\u9593\uff0c\u746a\u4ed5\u5ea6\u80bd\u7d44\u672a\u767c\u751f\u7814\u7a76\u8005\u5224\u5b9a\u8207\u746a\u4ed5\u5ea6\u80bd\u76f8\u95dc\u7684\u56b4\u91cd\u4e0d\u826f\u4e8b\u4ef6\u6216\u5c0e\u81f4\u7814\u7a76\u85e5\u7269\u6c38\u4e45\u505c\u7528\u7684\u4e0d\u826f\u4e8b\u4ef6<\/span><span>\u3002<\/span><\/li>\n<li><span>\u746a\u4ed5\u5ea6\u80bd\u7d44\u7684\u6574\u9ad4\u5b89\u5168\u6027\u7279\u5fb5\u8207\u746a\u4ed5\u5ea6\u80bd\u7684\u65e2\u5f80\u7814\u7a76\u548c\u5176\u4ed6<\/span><span>GLP-1R<\/span><span>\u985e\u85e5\u7269\u76f8\u4f3c\u3002\u6700\u5e38\u5831\u544a\u7684\u6cbb\u7642\u671f\u4e0d\u826f\u4e8b\u4ef6\u5305\u62ec\u5641\u5fc3\u3001\u8179\u7009\u548c\u5614\u5410\uff0c\u7d55\u5927\u90e8\u5206\u70ba\u8f15\u5ea6\u6216\u4e2d\u5ea6\uff0c\u5927\u591a\u767c\u751f\u65bc\u5291\u91cf\u6ef4\u5b9a\u671f<\/span><span>\u3002<\/span><\/li>\n<li><span>\u672c\u7814\u7a76\u4e2d\u89c0\u5bdf\u5230\u7684\u746a\u4ed5\u5ea6\u80bd\u5c0d\u53d7\u8a66\u8005\u5fc3\u7387\u7684\u5f71\u97ff\u8207\u5176\u4ed6<\/span><span>GLP-1R<\/span><span>\u985e\u85e5\u7269\u76f8\u8fd1\u3002\u672a\u89c0\u5bdf\u5230\u5fc3\u8840\u7ba1\u98a8\u96aa\u589e\u52a0\u7684\u5b89\u5168\u6027\u4fe1\u865f<\/span><span>\u3002<\/span><\/li>\n<\/ul>\n<p><span>\u9664\u6b64\u4e4b\u5916\uff0c\u746a\u4ed5\u5ea6\u80bd\u9084\u53ef\u660e\u986f\u964d\u4f4e\u8d85\u91cd\u548c\u80a5\u80d6\u53d7\u8a66\u8005\u7684\u8170\u570d\u3001\u8840\u58d3\u3001\u8840\u8102\u3001\u8f49\u6c28\u9176\u3001\u8840\u5c3f\u9178\u6c34\u5e73\u7b49\u5fc3\u8840\u7ba1\u4ee3\u8b1d\u6307\u6a19\u3002\u8a73\u7d30\u6578\u64da\u898b<\/span><span><a href=\"https:\/\/www.nature.com\/articles\/s41467-023-44067-4\" target=\"_blank\" rel=\"nofollow noopener\">Nature Communications<span>\u5168\u6587<\/span><\/a><\/span><span>\u3002<\/span><\/p>\n<p><b><span>\u95dc\u65bc\u80a5<\/span><\/b><b><span>\u80d6<\/span><\/b><\/p>\n<p><span>\u6211\u570b\u662f\u5168\u7403\u8d85\u91cd\u548c\u80a5\u80d6\u4eba\u53e3\u6700\u591a\u7684\u570b\u5bb6\uff0c\u4e14\u5448\u73fe\u9010\u6f38\u4e0a\u5347\u8da8\u52e2<\/span><span>\u3002<\/span><\/p>\n<p><span>\u80a5\u80d6\u53ef\u4ee5\u5c0e\u81f4\u4e00\u7cfb\u5217\u4f75\u767c\u75c7\u6216\u8005\u76f8\u95dc\u75be\u75c5\uff0c\u9032\u800c\u5f71\u97ff\u9810\u671f\u58fd\u547d\u6216\u8005\u5c0e\u81f4\u751f\u6d3b\u8cea\u91cf\u4e0b\u964d\u3002\u5728\u8f03\u70ba\u56b4\u91cd\u7684\u80a5\u80d6\u60a3\u8005\u4e2d\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u3001\u7cd6\u5c3f\u75c5\u548c\u67d0\u4e9b\u816b\u7624\u7684\u767c\u751f\u7387\u53ca\u6b7b\u4ea1\u7387\u660e\u986f\u4e0a\u5347\u3002<\/span><span>2019<\/span><span>\u5e74\u8d85\u91cd\u548c\u80a5\u80d6\u5c0e\u81f4\u7684\u6b7b\u4ea1\u5728\u6162\u6027\u975e\u50b3\u67d3\u6027\u75be\u75c5\u76f8\u95dc\u6b7b\u4ea1\u4e2d\u5360\u6bd4<\/span><span>11.1%<\/span><span>\uff0c\u76f8\u6bd4<\/span><span>1990<\/span><span>\u5e74\u7684<\/span><span>5.7%<\/span><span>\u986f\u8457\u589e\u52a0<\/span><span>[i]<\/span><span>\u3002<\/span><\/p>\n<p><span>\u80a5\u80d6\u75c7\u662f\u9700\u8981\u9577\u671f\u6cbb\u7642\u7684\u6162\u6027\u75be\u75c5\uff0c\u76ee\u524d\u7f3a\u4e4f\u9577\u671f\u6709\u6548\u4e14\u5b89\u5168\u7684\u6cbb\u7642\u624b\u6bb5\u3002\u751f\u6d3b\u65b9\u5f0f\u5e72\u9810\u662f\u8d85\u91cd\u6216\u80a5\u80d6\u8005\u7684\u9996\u9078\u548c\u57fa\u790e\u6cbb\u7642\u624b\u6bb5\uff0c\u4f46\u662f\u4ecd\u6709\u76f8\u7576\u4e00\u90e8\u5206\u60a3\u8005\u7531\u65bc\u7a2e\u7a2e\u539f\u56e0\u4e0d\u80fd\u9054\u5230\u671f\u671b\u7684\u6e1b\u91cd\u76ee\u6a19\uff0c\u9700\u7528\u85e5\u7269\u8f14\u52a9\u6e1b\u91cd\u3002\u50b3\u7d71\u6e1b\u80a5\u85e5\u6e1b\u91cd\u6548\u679c\u6709\u9650\uff0c\u4e14\u5b58\u5728\u5b89\u5168\u6027\u554f\u984c\uff0c\u5c0d\u7642\u6548\u66f4\u597d\u4e14\u5b89\u5168\u7684\u6e1b\u80a5\u7642\u6cd5\u7684\u9700\u6c42\u5c1a\u672a\u5f97\u5230\u6eff\u8db3<\/span><span>\u3002<\/span><\/p>\n<p><b><span>\u95dc\u65bc\u746a\u4ed5\u5ea6\u80bd\uff08<\/span><\/b><b><span>IBI362<\/span><\/b><b><span>\uff09<\/span><\/b><\/p>\n<p><span>\u746a\u4ed5\u5ea6\u80bd\uff08<\/span><span>IBI362<\/span><span>\uff09\u662f\u4fe1\u9054\u751f\u7269\u8207\u79ae\u4f86\u88fd\u85e5\u5171\u540c\u63a8\u9032\u7684\u4e00\u6b3e\u80f0\u9ad8\u8840\u7cd6\u7d20\u6a23\u80bd<\/span><span>-1<\/span><span>\u53d7\u9ad4\uff08<\/span><span>GLP-1R<\/span><span>\uff09<\/span><span>\/<\/span><span>\u80f0\u9ad8\u8840\u7cd6\u7d20\u53d7\u9ad4\uff08<\/span><span>GCGR<\/span><span>\uff09\u96d9\u91cd\u6fc0\u52d5\u5291\u3002\u4f5c\u70ba\u4e00\u7a2e\u54fa\u4e73\u52d5\u7269\u80c3\u6ccc\u9178\u8abf\u7bc0\u7d20\uff08<\/span><span>OXM<\/span><span>\uff09\u985e\u4f3c\u7269\uff0c\u746a\u4ed5\u5ea6\u80bd\u9664\u4e86\u901a\u904e\u6fc0\u52d5<\/span><span>GLP-1R<\/span><span>\u4fc3\u9032\u80f0\u5cf6\u7d20\u5206\u6ccc\u3001\u964d\u4f4e\u8840\u7cd6\u548c\u6e1b\u8f15\u9ad4\u91cd\u5916\uff0c\u9084\u53ef\u901a\u904e\u6fc0\u52d5<\/span><span>GCGR<\/span><span>\u589e\u52a0\u80fd\u91cf\u6d88\u8017\u589e\u5f37\u6e1b\u91cd\u7642\u6548\uff0c\u540c\u6642\u6539\u5584\u809d\u81df\u8102\u80aa\u4ee3\u8b1d\u3002\u746a\u4ed5\u5ea6\u80bd\u5df2\u5728\u591a\u9805\u81e8\u5e8a\u7814\u7a76\u4e2d\u5c55\u73fe\u51fa\u512a\u79c0\u7684\u6e1b\u91cd\u548c\u964d\u7cd6\u7642\u6548\uff0c\u4ee5\u53ca\u964d\u4f4e\u8170\u570d\u3001\u8840\u8102\u3001\u8840\u58d3\u3001\u8840\u5c3f\u9178\u3001\u809d\u9176\u53ca\u809d\u81df\u8102\u80aa\u542b\u91cf\uff0c\u4ee5\u53ca\u6539\u5584\u80f0\u5cf6\u7d20\u654f\u611f\u6027\uff0c\u5e36\u4f86\u591a\u91cd\u4ee3\u8b1d\u7372\u76ca\u3002\u76ee\u524d\uff0c\u746a\u4ed5\u5ea6\u80bd<\/span><span>4 mg<\/span><span>\u548c<\/span><span>6 mg<\/span><span>\u5728\u4e2d\u570b\u8d85\u91cd\u6216\u80a5\u80d6\uff08<\/span><span>GLORY-1<\/span><span>\uff09\u53d7\u8a66\u8005\u548c<\/span><span>2<\/span><span>\u578b\u7cd6\u5c3f\u75c5\uff08<\/span><span>DREAMS-1<\/span><span>\u548c<\/span><span>DREAMS-2<\/span><span>\uff09\u53d7\u8a66\u8005\u4e2d\u7684\u4e09\u9805<\/span><span>III<\/span><span>\u671f\u8a3b\u518a\u7814\u7a76\u6b63\u5728\u9032\u884c\u4e2d\uff1b\u746a\u4ed5\u5ea6\u80bd<\/span><span>9 mg<\/span><span>\u5728\u4e2d\u570b\u80a5\u80d6\u53d7\u8a66\u8005\u7684<\/span><span>III<\/span><span>\u671f\u81e8\u5e8a\u7814\u7a76\u5df2\u65bc<\/span><span>2023<\/span><span>\u5e74\u5e95\u555f\u52d5<\/span><span>\u3002<\/span><\/p>\n<p><b><span>\u95dc\u65bc\u4fe1\u9054\u751f<\/span><\/b><b><span>\u7269<\/span><\/b><\/p>\n<p><span>\u300c\u59cb\u65bc\u4fe1\uff0c\u9054\u65bc\u884c\u300d\uff0c\u958b\u767c\u51fa\u8001\u767e\u59d3\u7528\u5f97\u8d77\u7684\u9ad8\u8cea\u91cf\u751f\u7269\u85e5\uff0c\u662f\u4fe1\u9054\u751f\u7269\u7684\u4f7f\u547d\u548c\u76ee\u6a19\u3002\u4fe1\u9054\u751f\u7269\u6210\u7acb\u65bc<\/span><span>2011<\/span><span>\u5e74\uff0c\u81f4\u529b\u65bc\u7814\u767c\u3001\u751f\u7522\u548c\u92b7\u552e\u816b\u7624\u3001\u81ea\u8eab\u514d\u75ab\u3001\u4ee3\u8b1d\u3001\u773c\u79d1\u7b49\u91cd\u5927\u75be\u75c5\u9818\u57df\u7684\u5275\u65b0\u85e5\u7269\uff0c\u8b93\u6211\u5011\u7684\u5de5\u4f5c\u60e0\u53ca\u66f4\u591a\u7684\u751f\u547d\u3002\u516c\u53f8\u5df2\u6709<\/span><span>10<\/span><span>\u500b\u7522\u54c1\u7372\u5f97\u6279\u51c6\u4e0a\u5e02\uff0c\u5b83\u5011\u5206\u5225\u662f\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u8212<\/span><span>\u00ae<\/span><span>\uff09\uff0c\u8c9d\u4f10\u73e0\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u6538\u540c<\/span><span>\u00ae<\/span><span>\uff09\uff0c\u963f\u9054\u6728\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u8607\u7acb\u4fe1<\/span><span>\u00ae<\/span><span>\uff09\uff0c\u5229\u59a5\u6614\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u9054\u4f2f\u83ef<\/span><span>\u00ae<\/span><span>\uff09\uff0c\u4f69\u7c73\u66ff\u5c3c\u7247\uff08\u9054\u4f2f\u5766<\/span><span>\u00ae<\/span><span>\uff09\uff0c\u5967\u96f7\u5df4\u66ff\u5c3c\u7247\uff08\u8010\u7acb\u514b<\/span><span>\u00ae<\/span><span>\uff09\uff0c\u96f7\u83ab\u897f\u5c24\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u5e0c\u5189\u64c7<\/span><span>\u00ae<\/span><span>\uff09\uff0c\u585e\u666e\u66ff\u5c3c\u81a0\u56ca\uff08\u777f\u59a5<\/span><span>\u00ae<\/span><span>\uff09\uff0c\u4f0a\u57fa\u5967\u4f96\u8cfd\u6ce8\u5c04\u6db2\uff08\u798f\u53ef\u8607<\/span><span>\u00ae<\/span><span>\uff09\u548c\u6258\u840a\u897f\u55ae\u6297\u6ce8\u5c04\u6db2\uff08\u4fe1\u5fc5\u6a02<\/span><span>\u00ae<\/span><span>\uff09\u3002\u76ee\u524d\uff0c\u540c\u6642\u9084\u6709<\/span><span>2<\/span><span>\u500b\u54c1\u7a2e\u5728<\/span><span>NMPA<\/span><span>\u5be9\u8a55\u4e2d\uff0c<\/span><span>5<\/span><span>\u500b\u65b0\u85e5\u5206\u5b50\u9032\u5165<\/span><span>III<\/span><span>\u671f\u6216\u95dc\u9375\u6027\u81e8\u5e8a\u7814\u7a76\uff0c\u53e6\u5916\u9084\u6709<\/span><span>19<\/span><span>\u500b\u65b0\u85e5\u54c1\u7a2e\u5df2\u9032\u5165\u81e8\u5e8a\u7814\u7a76<\/span><span>\u3002<\/span><\/p>\n<p><span>\u516c\u53f8\u5df2\u8207\u79ae\u4f86\u3001\u7f85\u6c0f\u3001\u8cfd\u8afe\u83f2\u3001<\/span><span>Adimab<\/span><span>\u3001<\/span><span>Incyte<\/span><span>\u548c<\/span><span>MD Anderson <\/span><span>\u764c\u75c7\u4e2d\u5fc3\u7b49\u570b\u969b\u5408\u4f5c\u65b9\u9054\u6210<\/span><span>30<\/span><span>\u9805\u6230\u7565\u5408\u4f5c\u3002\u4fe1\u9054\u751f\u7269\u5728\u4e0d\u65b7\u81ea\u7814\u5275\u65b0\u85e5\u7269\u3001\u8b00\u6c42\u81ea\u8eab\u767c\u5c55\u7684\u540c\u6642\uff0c\u79c9\u627f\u7d93\u6fdf\u5efa\u8a2d\u4ee5\u4eba\u6c11\u70ba\u4e2d\u5fc3\u7684\u767c\u5c55\u601d\u60f3\u3002\u591a\u5e74\u4f86\uff0c\u59cb\u7d42\u5fc3\u61f7\u79d1\u5b78\u5584\u5ff5\uff0c\u5805\u5b88\u300c\u4ee5\u60a3\u8005\u70ba\u4e2d\u5fc3\u300d\uff0c\u5fc3\u7e6b\u60a3\u8005\u4e26\u95dc\u6ce8\u60a3\u8005\u5bb6\u5ead\uff0c\u7a4d\u6975\u5c65\u884c\u793e\u6703\u8cac\u4efb\u3002\u516c\u53f8\u9678\u7e8c\u767c\u8d77\u3001\u53c3\u8207\u4e86\u591a\u9805\u85e5\u54c1\u516c\u76ca\u63f4\u52a9\u9805\u76ee\uff0c\u8b93\u8d8a\u4f86\u8d8a\u591a\u7684\u60a3\u8005\u80fd\u5920\u5f97\u76ca\u65bc\u751f\u547d\u79d1\u5b78\u7684\u9032\u6b65\uff0c\u8cb7\u5f97\u5230\u3001\u7528\u5f97\u8d77\u9ad8\u8cea\u91cf\u7684\u751f\u7269\u85e5\u3002\u81f3<\/span><span>2023<\/span><span>\u5e74<\/span><span>10<\/span><span>\u6708\uff0c\u4fe1\u9054\u751f\u7269\u60a3\u8005\u63f4\u52a9\u9805\u76ee\u5df2\u60e0\u53ca<\/span><span>17<\/span><span>\u4f59\u842c\u666e\u901a\u60a3\u8005\uff0c\u85e5\u7269\u6350\u8d08\u7e3d\u50f9\u503c<\/span><span>34<\/span><span>\u5104\u4eba\u6c11\u5e63\u3002\u4fe1\u9054\u751f\u7269\u5e0c\u671b\u548c\u5927\u5bb6\u4e00\u8d77\u52aa\u529b\uff0c\u63d0\u9ad8\u4e2d\u570b\u751f\u7269\u88fd\u85e5\u7522\u696d\u7684\u767c\u5c55\u6c34\u5e73\uff0c\u4ee5\u6eff\u8db3\u767e\u59d3\u7528\u85e5\u53ef\u53ca\u6027\u548c\u4eba\u6c11\u5c0d\u751f\u547d\u5065\u5eb7\u7f8e\u597d\u9858\u671b\u7684\u8ffd\u6c42<\/span><span>\u3002<\/span><\/p>\n<p><span>\u8a73\u60c5\u8acb\u8a2a\u554f\u516c\u53f8\u7db2\u7ad9\uff1a<\/span><span><a href=\"http:\/\/www.innoventbio.com\/\" rel=\"nofollow\">www.innoventbio.com<\/a><\/span><span>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f<\/span><span><a href=\"http:\/\/www.linkedin.com\/company\/innovent-biologics\/\" rel=\"nofollow\">www.linkedin.com\/company\/innovent-biologics\/<\/a><\/span><span>\u3002<\/span><\/p>\n<p><span>\u8072\u660e\uff1a<i>\u4fe1\u9054\u4e0d\u63a8\u85a6\u4efb\u4f55\u672a\u7372\u6279\u7684\u85e5\u54c1<\/i><\/span><i><span>\/<\/span><\/i><i><span>\u9069\u61c9\u75c7\u4f7f\u7528<\/span><\/i><i><span>\u3002<\/span><\/i><\/p>\n<p><b><span>\u524d\u77bb\u6027\u8072<\/span><\/b><b><span>\u660e<\/span><\/b><\/p>\n<p><span>\u672c\u65b0\u805e\u7a3f\u6240\u767c\u4f48\u7684\u4fe1\u606f\u4e2d\u53ef\u80fd\u6703\u5305\u542b\u67d0\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u3002\u9019\u4e9b\u8868\u8ff0\u672c\u8cea\u4e0a\u5177\u6709\u76f8\u7576\u98a8\u96aa\u548c\u4e0d\u78ba\u5b9a\u6027\u3002\u5728\u4f7f\u7528\u300c\u9810\u671f\u300d\u3001\u300c\u76f8\u4fe1\u300d\u3001\u300c\u9810\u6e2c\u300d\u3001\u300c\u671f\u671b\u300d\u3001\u300c\u6253\u7b97\u300d\u53ca\u5176\u4ed6\u985e\u4f3c\u8a5e\u8a9e\u9032\u884c\u8868\u8ff0\u6642\uff0c\u51e1\u8207\u672c\u516c\u53f8\u6709\u95dc\u7684\uff0c\u76ee\u7684\u5747\u662f\u8981\u6307\u660e\u5176\u5c6c\u524d\u77bb\u6027\u8868\u8ff0\u3002\u672c\u516c\u53f8\u4e26\u7121\u7fa9\u52d9\u4e0d\u65b7\u5730\u66f4\u65b0\u9019\u4e9b\u9810\u6e2c\u6027\u9673\u8ff0<\/span><span>\u3002<\/span><\/p>\n<p><span>\u9019\u4e9b\u524d\u77bb\u6027\u8868\u8ff0\u4e43\u57fa\u65bc\u672c\u516c\u53f8\u7ba1\u7406\u5c64\u5728\u505a\u51fa\u8868\u8ff0\u6642\u5c0d\u672a\u4f86\u4e8b\u52d9\u7684\u73fe\u6709\u770b\u6cd5\u3001\u5047\u8a2d\u3001\u671f\u671b\u3001\u4f30\u8a08\u3001\u9810\u6e2c\u548c\u7406\u89e3\u3002\u9019\u4e9b\u8868\u8ff0\u4e26\u975e\u5c0d\u672a\u4f86\u767c\u5c55\u7684\u4fdd\u8b49\uff0c\u6703\u53d7\u5230\u98a8\u96aa\u3001\u4e0d\u78ba\u6027\u53ca\u5176\u4ed6\u56e0\u7d20\u7684\u5f71\u97ff\uff0c\u6709\u4e9b\u4e43\u8d85\u51fa\u672c\u516c\u53f8\u7684\u63a7\u5236\u7bc4\u570d\uff0c\u96e3\u4ee5\u9810\u8a08\u3002\u56e0\u6b64\uff0c\u53d7\u6211\u5011\u7684\u696d\u52d9\u3001\u7af6\u722d\u74b0\u5883\u3001\u653f\u6cbb\u3001\u7d93\u6fdf\u3001\u6cd5\u5f8b\u548c\u793e\u6703\u60c5\u6cc1\u7684\u672a\u4f86\u8b8a\u5316\u53ca\u767c\u5c55\u7684\u5f71\u97ff\uff0c\u5be6\u969b\u7d50\u679c\u53ef\u80fd\u6703\u8207\u524d\u77bb\u6027\u8868\u8ff0\u6240\u542b\u8cc7\u6599\u6709\u8f03\u5927\u5dee\u5225<\/span><span>\u3002<\/span><\/p>\n<p><span>\u53c3\u8003\u6587<\/span><span>\u737b<\/span><\/p>\n<p><sup><span>[i]<\/span><\/sup> Institute for Health Metrics and Evaluation. Global Health Data Exchange. GBD results tool. <a href=\"http:\/\/ghdx.healthdata.org\/gbd-resultstool\" target=\"_blank\" rel=\"nofollow noopener\">http:\/\/ghdx.healthdata.org\/gbd-resultstool<\/a> (accessed <span class=\"xn-chron\">Jan 10, 2021<\/span>).<\/p>\n<div class=\"PRN_ImbeddedAssetReference\" id=\"DivAssetPlaceHolder0\">  <\/div>\n<\/div>\n<p>\n\u65b0\u805e\u4f86\u6e90\uff1aPR Newswire<\/p>\n<p>\u4ee5\u4e0a\u65b0\u805e\u6295\u7a3f\u5167\u5bb9\u7531PR Newswire \u7f8e\u901a\u793e\u5168\u6b0a\u81ea\u8ca0\u8cac\u4efb\uff0c\u82e5\u6709\u6d89\u53ca\u4efb\u4f55\u9055\u53cd\u6cd5\u4ee4\u3001\u9055\u53cd\u672c\u7db2\u7ad9\u6703\u54e1\u689d\u6b3e\u3001\u6709\u4fb5\u5bb3\u7b2c\u4e09\u4eba\u6b0a\u76ca\u4e4b\u865e\uff0c\u5c07\u4e00\u6982\u7531PR Newswire \u7f8e\u901a\u793e\u627f\u64d4\u6cd5\u5f8b\u53ca\u640d\u5bb3\u8ce0\u511f\u4e4b\u8cac\u4efb\uff0c\u8207\u65b0\u982d\u689dThehubnews\u7121\u95dc\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2023\u5e7412\u670818\u65e5<\/p>\n","protected":false},"author":6,"featured_media":107582,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[423],"class_list":["post-107581","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-life","tag-423","two-columns"],"_links":{"self":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts\/107581","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=107581"}],"version-history":[{"count":0,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts\/107581\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/media\/107582"}],"wp:attachment":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=107581"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=107581"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=107581"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}