{"id":103599,"date":"2023-12-06T08:16:00","date_gmt":"2023-12-06T00:16:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=103599"},"modified":"2023-12-06T08:16:00","modified_gmt":"2023-12-06T00:16:00","slug":"%e3%80%8a%e7%be%8e%e5%9c%8b%e9%86%ab%e5%ad%b8%e6%9c%83%e9%9b%9c%e8%aa%8c%e3%80%8b%ef%bc%88jama%ef%bc%89%e7%99%bc%e8%a1%a8%e4%bf%a1%e8%bf%aa%e5%88%a9%e5%96%ae%e6%8a%97%e8%81%af%e5%90%88%e5%8c%96","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=103599","title":{"rendered":"\u300a\u7f8e\u570b\u91ab\u5b78\u6703\u96dc\u8a8c\u300b\uff08JAMA\uff09\u767c\u8868\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u4e00\u7dda\u6cbb\u7642\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u7684III\u671f\u81e8\u5e8aORIENT-16\u7814\u7a76\u7d50\u679c"},"content":{"rendered":"<div>\n<div>\n<p><span class=\"legendSpanClass\">\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde<\/span><span class=\"legendSpanClass\">2023\u5e7412\u67086\u65e5<\/span> 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type=\"disc\">\n<li>\u671f\u4e2d\u5206\u6790\u7d50\u679c\u986f\u793a\uff08\u622a\u81f32021\u5e746\u670820\u65e5\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u959318.8\u500b\u6708\uff09\uff0c\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u986f\u8457\u964d\u4f4e\u7e3d\u9ad4\u4eba\u7fa4\uff08HR 0.77\uff0c95%CI 0.63-0.94\uff0cp=0.009\uff09\u548cCPS\u22655\u4eba\u7fa4\uff08HR 0.66\uff0c95%CI 0.50-0.86\uff0cp=0.002\uff09\u7684\u6b7b\u4ea1\u98a8\u96aa\uff0c\u9054\u5230\u9810\u8a2d\u7684\u512a\u6548\u6027\u6a19\u6e96\uff1b\u4e2d\u4f4d\u751f\u5b58\u671f\uff08mOS\uff09\u5728\u7e3d\u9ad4\u4eba\u7fa4\u5ef6\u95772.9\u500b\u6708\uff08mOS 15.2\u6708 vs. 12.3\u6708\uff09\uff0c\u5728CPS\u22655\u4eba\u7fa4\u5ef6\u95775.5\u500b\u6708\uff08mOS 18.4\u6708 vs. 12.9\u6708\uff09\u3002\u7e3d\u751f\u5b58\u671f\u5728\u9810\u8a2d\u7684\u6240\u6709\u4e9e\u7d44\u5206\u6790\u4e2d\u7372\u76ca\u8da8\u52e2\u4e00\u81f4\u3002\u5b89\u5168\u6027\u7279\u5fb5\u8207\u65e2\u5f80\u5831\u9053\u7684\u4fe1\u8fea\u5229\u55ae\u6297\u76f8\u95dc\u81e8\u5e8a\u7814\u7a76\u7d50\u679c\u4e00\u81f4\uff0c\u7121\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002<\/li>\n<\/ul>\n<p><b>\u6b64\u5916\uff0c<\/b><b>ORIENT-16\u7814\u7a76\u7684\u6700\u7d42\u5206\u6790\u7d50\u679c\u5df2\u57282023\u5e74\u7f8e\u570b\u764c\u75c7\u7814\u7a76\u5354\u6703\u5e74\u6703\uff08AACR 2023\uff09\u767c\u8868\uff0c<\/b>\u6700\u7d42\u5206\u6790\u7684\u7d50\u679c\u8868\u660e\uff0c\u96a8\u8457\u96a8\u8a2a\u6642\u9593\u7684\u5ef6\u9577\uff0c\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u5728\u4e00\u7dda\u80c3\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u7684\u5168\u4eba\u7fa4\u8207CPS\u22655\u7684\u4eba\u7fa4\u4e2d\u986f\u793a\u51fa\u6301\u4e45\u986f\u8457\u7684\u751f\u5b58\u7372\u76ca\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u61c9\u4f5c\u70ba\u665a\u671f\u4e00\u7dda\u80c3\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u60a3\u8005\u7684\u6a19\u6e96\u6cbb\u7642\u3002<\/p>\n<ul type=\"disc\">\n<li>\u6700\u7d42\u5206\u6790\u7d50\u679c\u986f\u793a\uff08\u622a\u81f32022\u5e749\u67082\u65e5\uff0c\u4e2d\u4f4d\u96a8\u8a2a\u6642\u959333.9\u6708\uff09\uff0c\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u986f\u8457\u964d\u4f4e\u7e3d\u9ad4\u4eba\u7fa4\uff08HR 0.68 [95% CI: 0.57, 0.81]; P<0.0001\uff09\u548cCPS\u22655\u4eba\u7fa4\uff08HR 0.59 [95% CI: 0.47, 0.74]; P<0.0001\uff09\u7684\u6b7b\u4ea1\u98a8\u96aa\uff1b\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\uff08mOS\uff09\u5728\u7e3d\u9ad4\u4eba\u7fa4\u5ef6\u95772.9\u500b\u6708\uff08mOS 15.2\u6708 vs. 12.3\u6708\uff09\uff0c\u5728CPS\u22655\u4eba\u7fa4\u5ef6\u95776.3\u500b\u6708\uff08mOS 19.2\u6708 vs 12.9 \u6708\uff09\uff0c\u4e26\u4e14\u5728\u9810\u8a2d\u7684\u6240\u6709\u4e9e\u7d44\u5206\u6790\u4e2d\u7372\u76ca\u8da8\u52e2\u4e00\u81f4\u3002\u5b89\u5168\u6027\u7279\u5fb5\u8207\u671f\u4e2d\u5206\u6790\u5831\u9053\u7684\u7814\u7a76\u7d50\u679c\u57fa\u672c\u4e00\u81f4\uff0c\u7121\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002<\/li>\n<\/ul>\n<p>\u57fa\u65bc\u8a72\u8a3b\u518a\u7814\u7a76\u7684\u7642\u6548\u8207\u5b89\u5168\u6027\u7d50\u679c\uff0c\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u5df2\u65bc2022\u5e746\u6708\u6279\u51c6\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u7528\u65bc\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff0c\u4e26\u901a\u904e\u91ab\u4fdd\u8ac7\u5224\u6210\u529f\u7d0d\u51652022\u5e74\u7248\u570b\u5bb6\u91ab\u4fdd\u85e5\u54c1\u76ee\u9304\uff0c\u6210\u70ba\u4e2d\u570b\u9996\u500b\u4e14\u552f\u4e00\u80c3\u764c\u4e00\u7dda\u5168\u4eba\u7fa4\u91ab\u4fdd\u7684PD-1\u6291\u5236\u5291\u3002<\/p>\n<p><b>\u8a72\u6587\u7ae0\u7684\u901a\u8a0a\u4f5c\u8005\u3001<\/b><b>ORIENT-16\u7814\u7a76\u7684\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u89e3\u653e\u8ecd\u7e3d\u91ab\u9662\u7b2c\u4e94\u91ab\u5b78\u4e2d\u5fc3\u6d88\u5316\u816b\u7624\u5167\u79d1\u5f90\u5efa\u660e\u4e3b\u4efb<\/b>\u8868\u793a\uff1a\u300cORIENT-16\u7814\u7a76\u662f\u9996\u500b\u57fa\u65bc\u4e2d\u570b\u4eba\u7fa4\u8b49\u5be6PD-1\u55ae\u6297\u806f\u5408\u5316\u7642\u4e00\u7dda\u6cbb\u7642\u80fd\u5920\u986f\u8457\u5ef6\u9577\u5c40\u90e8\u665a\u671f\u3001\u8f49\u79fb\u6027\u80c3\u764c\u75c5\u4eba\u7e3d\u751f\u5b58\u671f\u7684\u96a8\u6a5f\u5c0d\u7167III\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u4fe1\u8fea\u5229\u55ae\u6297\u4e5f\u662f\u9996\u500b\u4e14\u552f\u4e00\u80c3\u764c\u4e00\u7dda\u5168\u4eba\u7fa4\u91ab\u4fdd\u7684PD-1\u6291\u5236\u5291\uff0c\u540c\u6642\u552f\u4e00\u7372\u4e2d\u570b\u81e8\u5e8a\u816b\u7624\u5b78\u6703\uff08CSCO\uff09\u6307\u5357\u80c3\u764c\u4e00\u7dda\u5168\u4eba\u7fa4\u63a8\u85a6\u3002\u672c\u7814\u7a76\u5728\u9810\u8a2d\u7684\u671f\u4e2d\u5206\u6790\u5373\u9054\u5230\u4e86\u7814\u7a76\u7684\u4e3b\u8981\u7d42\u9ede\uff0c\u4e26\u5728\u6700\u7d42\u5206\u6790\u8b49\u5be6\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u5728\u4e00\u7dda\u80c3\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u7684\u5168\u4eba\u7fa4\u4e2d\u5177\u6709\u6301\u7e8c\u986f\u8457\u7684\u751f\u5b58\u7372\u76ca\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u61c9\u4f5c\u70ba\u4e2d\u570b\u5c40\u90e8\u665a\u671f\u53ca\u8f49\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u60a3\u8005\u7684\u4e00\u7dda\u6a19\u6e96\u6cbb\u7642\u3002\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u5728\u4e00\u7dda\u80c3\u6216\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\uff0c\u7d66\u5ee3\u5927\u80c3\u764c\u60a3\u8005\u5e36\u4f86\u4e86\u65b0\u7684\u66f4\u6709\u6548\u7684\u6cbb\u7642\u9078\u64c7\u3002\u300d<\/p>\n<p><b>\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u96c6\u5718\u9ad8\u7d1a\u526f\u7e3d\u88c1\u5468\u8f1d\u535a\u58eb<\/b>\u8868\u793a\uff1a\u300c\u665a\u671f\u80c3\u764c\u7684\u6cbb\u7642\u624b\u6bb5\u5b58\u5728\u5de8\u5927\u7684\u672a\u6eff\u8db3\u7684\u81e8\u5e8a\u9700\u6c42\u3002ORIENT-16\u662f\u570b\u5167\u9996\u500b\u8b49\u5be6PD-1\u55ae\u6297\u806f\u5408\u5316\u7642\u5728\u665a\u671f\u4e00\u7dda\u80c3\u764c\u5168\u4eba\u7fa4\u4e2d\u986f\u8457\u5ef6\u9577\u7e3d\u751f\u5b58\u671f\u7684\u96a8\u6a5f\u5c0d\u7167III\u671f\u81e8\u5e8a\u7814\u7a76\u3002\u6b64\u6b21\u671f\u4e2d\u5206\u6790\u7d50\u679c\u5728\u570b\u969b\u91cd\u78c5\u671f\u520a\u96dc\u8a8cJAMA\u4e0a\u7684\u5168\u6587\u767c\u8868\uff0c\u9032\u4e00\u6b65\u8b49\u5be6\u4e86\u4fe1\u8fea\u5229\u55ae\u6297\u806f\u5408\u5316\u7642\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6027\u6216\u8f49\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u7684\u81e8\u5e8a\u50f9\u503c\u3002\u6211\u5011\u7531\u8877\u5730\u611f\u8b1d\u53c3\u52a0\u672c\u7814\u7a76\u7684\u5168\u9ad4\u7814\u7a76\u8005\u548c\u53d7\u8a66\u8005\uff0c\u8207\u6211\u5011\u4e00\u8d77\u5b8c\u6210\u4e86\u9019\u9805\u5177\u6709\u91cc\u7a0b\u7891\u610f\u7fa9\u7684\u81e8\u5e8a\u7814\u7a76\u3002\u9019\u9805\u7814\u7a76\u7684\u6210\u529f\u4e5f\u4f7f\u5f97\u9054\u4f2f\u8212\u6210\u70ba\u552f\u4e00\u5c07\u4e94\u5927\u9ad8\u767c\u7624\u7a2e\uff08\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\u3001\u809d\u764c\u3001\u98df\u7ba1\u764c\u548c\u80c3\u764c\uff09\u4e00\u7dda\u6cbb\u7642\u5747\u7372\u6279\u4e26\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\u7684PD-1\u6291\u5236\u5291\u3002\u76ee\u524d\u9054\u4f2f\u8212\u4e5f\u662f\u552f\u4e00\u80c3\u764c\u4e00\u7dda\u5168\u4eba\u7fa4\u91ab\u4fdd\u7684PD-1\u6291\u5236\u5291\uff0c\u5e0c\u671b\u9020\u798f\u66f4\u5ee3\u95ca\u7684\u80c3\u764c\u60a3\u8005\u3002\u300d<\/p>\n<p><b>\u95dc\u65bc<\/b><b>JAMA<\/b><\/p>\n<p>JAMA\u662f\u540c\u884c\u8a55\u5be9\u7684\u570b\u969b\u7d9c\u5408\u6027\u91ab\u5b78\u671f\u520a\uff0c\u4ee5\u4fc3\u9032\u91ab\u5b78\u7684\u79d1\u5b78\u8207\u85dd\u8853\u4ee5\u53ca\u6539\u5584\u516c\u5171\u885b\u751f\u70ba\u4e3b\u8981\u76ee\u6a19\u3002\u81ea1883\u5e74\u9023\u7e8c\u51fa\u7248\u4ee5\u4f86\uff0cJAMA\u5df2\u6210\u70ba\u91ab\u5b78\u548c\u79d1\u5b78\u9818\u57df\u6700\u5177\u5f71\u97ff\u529b\u7684\u671f\u520a\u4e4b\u4e00\uff0c2023\u5e74\u6700\u65b0\u5f71\u97ff\u56e0\u5b50\u70ba120.7\u5206\u3002JAMA\u4e5f\u662f\u4e16\u754c\u4e0a\u767c\u884c\u6700\u5ee3\u6cdb\u7684\u7d9c\u5408\u6027\u91ab\u5b78\u985e\u671f\u520a\uff0c\u5370\u5237\u7248\u8a02\u95b1\u6578\u8d85\u904e29\u842c\uff0c\u7db2\u7d61\u8a02\u95b1\u6578\u8d85\u904e160\u842c\uff0c\u671f\u520a\u7db2\u7ad9\u7684\u5e74\u8a2a\u554f\u91cf\u8d85\u904e3800\u842c\uff0c\u5177\u6709\u5f37\u5927\u7684\u793e\u4ea4\u5a92\u9ad4\u5f71\u97ff\u529b\u548c\u570b\u969b\u65b0\u805e\u5a92\u9ad4\u7684\u66dd\u5149\u7387\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>ORIENT-16\u7814\u7a76<\/b><\/p>\n<p>ORIENT-16\u7814\u7a76\u662f\u4e00\u9805\u6bd4\u8f03\u4fe1\u8fea\u5229\u55ae\u6297\u6216\u5b89\u6170\u5291\uff0c\u806f\u5408\u5316\u7642\uff08\u5967\u6c99\u5229\u9251+\u5361\u57f9\u4ed6\u6ff1\uff09\u4e00\u7dda\u6cbb\u7642\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6027\u6216\u8f49\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u7684\u6709\u6548\u6027\u548c\u5b89\u5168\u6027\u7684\u96a8\u6a5f\u3001\u96d9\u76f2\u3001\u591a\u4e2d\u5fc3\u3001III\u671f\u7814\u7a76\uff08ClinicalTrials.gov, NCT03745170\uff09\u3002\u4e3b\u8981\u7814\u7a76\u7d42\u9ede\u70ba\u7e3d\u9ad4\u4eba\u7fa4\u548cPD-L1\u967d\u6027\u4eba\u7fa4(CPS\u22655)\u7684\u7e3d\u751f\u5b58\u671f\uff08OS\uff09\u3002<\/p>\n<p><b>\u95dc\u65bc\u80c3\u764c<\/b><\/p>\n<p>\u80c3\u764c\u662f\u5168\u4e16\u754c\u5e38\u898b\u7684\u60e1\u6027\u816b\u7624\u4e4b\u4e00\uff0c\u6839\u64da\u4e16\u754c\u885b\u751f\u7d44\u7e54GLOBOCAN\u7db2\u7d61\u7684\u6578\u64da\uff0c2020\u5e74\u5168\u7403\u80c3\u764c\u65b0\u767c\u75c5\u4f8b\u8d85\u904e100\u842c\uff08\u7d04\u5360\u6240\u6709\u764c\u75c7\u65b0\u767c\u75c5\u4f8b\u76845.6%\uff09\uff0c\u6210\u70ba\u5168\u4e16\u754c\u7b2c\u4e94\u5927\u5e38\u898b\u60e1\u6027\u816b\u7624\u3002\u5176\u4e2d\u4e00\u534a\u7684\u75c5\u4f8b\u767c\u751f\u5728\u6771\u4e9e\uff0c\u4e3b\u8981\u662f\u5728\u4e2d\u570b\u3002\u80c3\u764c\u662f\u5168\u7403\u764c\u75c7\u6b7b\u4ea1\u7684\u7b2c\u4e09\u5927\u539f\u56e0\uff0c\u5168\u4e16\u754c\u6bcf\u5e74\u7d04\u6709769,000\u540d\u60a3\u8005\u6b7b\u65bc\u80c3\u764c<sup>[ii]<\/sup>\u3002\u665a\u671f\u6216\u8f49\u79fb\u6027\u80c3\u764c\u76845\u5e74\u751f\u5b58\u7387\u7d04\u70ba5%\u81f320%\uff0c\u63a5\u53d7\u55ae\u7d14\u5316\u7642\u7684\u60a3\u8005\u4e2d\u4f4d\u7e3d\u751f\u5b58\u671f\u50c51\u5e74\u5de6\u53f3<sup>[iii][iv]<\/sup>\u3002<\/p>\n<p><b>\u95dc\u65bc\u4fe1\u8fea\u5229\u55ae\u6297<\/b><\/p>\n<p>\u4fe1\u8fea\u5229\u55ae\u6297\uff0c\u4e2d\u570b\u5546\u54c1\u540d\u70ba\u9054\u4f2f\u8212\u00ae\uff08\u4fe1\u8fea\u5229\u55ae\u6297\u6ce8\u5c04\u6db2\uff09\uff0c\u662f\u4fe1\u9054\u751f\u7269\u88fd\u85e5\u548c\u79ae\u4f86\u88fd\u85e5\u5171\u540c\u5408\u4f5c\u7814\u767c\u7684\u5177\u6709\u570b\u969b\u54c1\u8cea\u7684\u5275\u65b0PD-1\u6291\u5236\u5291\u85e5\u7269\u3002\u4fe1\u8fea\u5229\u55ae\u6297\u662f\u4e00\u7a2e\u4eba\u985e\u514d\u75ab\u7403\u86cb\u767dG4\uff08IgG4\uff09\u55ae\u514b\u9686\u6297\u9ad4\uff0c\u80fd\u7279\u7570\u6027\u7d50\u5408T\u7d30\u80de\u8868\u9762\u7684PD-1\u5206\u5b50\uff0c\u5f9e\u800c\u963b\u65b7\u5c0e\u81f4\u816b\u7624\u514d\u75ab\u8010\u53d7\u7684 PD-1\/\u7a0b\u5e8f\u6027\u6b7b\u4ea1\u53d7\u9ad4\u914d\u9ad41\uff08Programmed Death-Ligand 1, PD-L1\uff09\u901a\u8def\uff0c\u91cd\u65b0\u6fc0\u6d3b\u6dcb\u5df4\u7d30\u80de\u7684\u6297\u816b\u7624\u6d3b\u6027\uff0c\u5f9e\u800c\u9054\u5230\u6cbb\u7642\u816b\u7624\u7684\u76ee\u7684<sup>[v]<\/sup>\u3002\u76ee\u524d\u6709\u8d85\u904e\u4e8c\u5341\u591a\u500b\u81e8\u5e8a\u7814\u7a76\uff08\u5176\u4e2d10\u591a\u9805\u662f\u8a3b\u518a\u81e8\u5e8a\u8a66\u9a57\uff09\u6b63\u5728\u9032\u884c\uff0c\u4ee5\u8a55\u4f30\u4fe1\u8fea\u5229\u55ae\u6297\u5728\u5404\u985e\u5be6\u9ad4\u816b\u7624\u548c\u8840\u6db2\u816b\u7624\u4e0a\u7684\u6297\u816b\u7624\u4f5c\u7528\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u55ae\u6297\u5df2\u5728\u4e2d\u570b\u7372\u6279\u4e03\u9805\u9069\u61c9\u75c7\uff0c\u5176\u4e2d\u524d\u516d\u9805\u5df2\u7d0d\u5165\u570b\u5bb6\u91ab\u4fdd\u76ee\u9304\uff0c\u5354\u8b70\u671f\u5167\u91ab\u4fdd\u76ee\u9304\u63cf\u8ff0\u7684\u9650\u5b9a\u652f\u4ed8\u7bc4\u570d\u5305\u62ec\uff1a<\/p>\n<ul type=\"disc\">\n<li>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u98df\u7ba1\u9c57\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u4e0d\u53ef\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u3001\u5fa9\u767c\u6216\u8f49\u79fb\u6027\u80c3\u53ca\u80c3\u98df\u7ba1\u4ea4\u754c\u8655\u817a\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4(EGFR\uff09\u57fa\u56e0\u7a81\u8b8a\u9670\u6027\u548c\u9593\u8b8a\u6027\u6dcb\u5df4\u7624\u6fc0\u9176\uff08ALK\uff09\u9670\u6027\u3001\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u4e0d\u53ef\u624b\u8853\u5207\u9664\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u65e2\u5f80\u672a\u63a5\u53d7\u904e\u7cfb\u7d71\u6cbb\u7642\u7684\u4e0d\u53ef\u5207\u9664\u6216\u8f49\u79fb\u6027\u809d\u7d30\u80de\u764c\u7684\u4e00\u7dda\u6cbb\u7642\uff1b<\/li>\n<li>\u81f3\u5c11\u7d93\u904e\u4e8c\u7dda\u7cfb\u7d71\u5316\u7642\u7684\u5fa9\u767c\u6216\u96e3\u6cbb\u6027\u7d93\u5178\u578b\u970d\u5947\u91d1\u6dcb\u5df4\u7624\u7684\u6cbb\u7642\u3002<\/li>\n<\/ul>\n<p>\u53e6\u5916\uff0c \u4fe1\u8fea\u5229\u55ae\u6297\u5df2\u7372\u6279\u806f\u5408\u8c9d\u4f10\u73e0\u55ae\u6297\u3001\u57f9\u7f8e\u66f2\u585e\u548c\u9806\u9251\uff0c\u7528\u65bc\u7d93\u8868\u76ae\u751f\u9577\u56e0\u5b50\u53d7\u9ad4\u916a\u6c28\u9178\u6fc0\u9176\u6291\u5236\u5291\uff08EGFR-TKI\uff09\u6cbb\u7642\u5931\u6557\u7684EGFR\u57fa\u56e0\u7a81\u8b8a\u967d\u6027\u7684\u5c40\u90e8\u665a\u671f\u6216\u8f49\u79fb\u6027\u975e\u9c57\u72c0\u975e\u5c0f\u7d30\u80de\u80ba\u764c\uff08NSCLC\uff09\u60a3\u8005\u7684\u6cbb\u7642\u3002<\/p>\n<p>\u4fe1\u8fea\u5229\u55ae\u6297\u53e6\u6709\u5169\u9805\u81e8\u5e8a\u8a66\u9a57\u9054\u5230\u7814\u7a76\u7d42\u9ede\uff0c\u5305\u62ec\uff1a<\/p>\n<ul 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(a) \u66f4\u6b63\u6216\u66f4\u65b0\u672c\u7db2\u7ad9\u6240\u8f09\u524d\u77bb\u6027\u8868\u8ff0\u7684\u4efb\u4f55\u7fa9\u52d9;\u53ca (b) \u82e5\u56e0\u4efb\u4f55\u524d\u77bb\u6027\u8868\u8ff0\u4e0d\u80fd\u5be6\u73fe\u6216\u8b8a\u6210\u4e0d\u6b63\u78ba\u800c\u5f15\u81f4\u7684\u4efb\u4f55\u8cac\u4efb\u3002<\/p>\n<div>\n<table border=\"0\" cellspacing=\"0\" cellpadding=\"1\" class=\"prnbcc\">\n<tbody>\n<tr>\n<td class=\"prnpr2 prnpl2 prnvab prnsbtb0 prnrbrb0 prnsbbb0 prnsblb0\" colspan=\"1\" rowspan=\"1\">\n<p class=\"prnml4\"><span class=\"prnews_span\">[i] Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3): 209-249.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[ii] Fuchs CS, Shitara K, Di Bartolomeo M, et al. Ramucirumab with cisplatin and fluoropyrimidine as first-line therapy in patients with metastatic gastric or junctional adenocarcinoma (RAINFALL): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Oncol. 2019; 20(3): 420-435.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[iii] Wang H, Guo W, Hu Y, et al. Superiority of the 8th edition of the TNM staging system for predicting overall survival in gastric cancer: Comparative analysis of the 7th and 8th editions in a monoinstitutional cohort[J]. Molecular and Clinical Oncology, 2018, 9(4): 423-431.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[iv] Price TJ, Shapiro JD, Segelov E, Karapetis CS, Pavlakis N, Van Cutsem E, Shah MA, Kang YK, Tebbutt NC. Management of advanced gastric cancer. Expert Rev Gastroenterol Hepatol. 2012 Apr;6(2):199-208; quiz 209. doi: 10.1586\/egh.11.103. PMID: 22375525.<\/span><\/p>\n<p class=\"prnml4\"><span class=\"prnews_span\">[v] Wang J, Fei K, Jing H, et al. Durable blockade of PD-1 signaling links preclinical efficacy of sintilimab to its clinical benefit. mAbs 2019;11(8): 1443-1451.<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<p>\u00a0<\/p>\n<\/div>\n<p>\n\u65b0\u805e\u4f86\u6e90\uff1aPR Newswire<\/p>\n<p>\u4ee5\u4e0a\u65b0\u805e\u6295\u7a3f\u5167\u5bb9\u7531PR Newswire \u7f8e\u901a\u793e\u5168\u6b0a\u81ea\u8ca0\u8cac\u4efb\uff0c\u82e5\u6709\u6d89\u53ca\u4efb\u4f55\u9055\u53cd\u6cd5\u4ee4\u3001\u9055\u53cd\u672c\u7db2\u7ad9\u6703\u54e1\u689d\u6b3e\u3001\u6709\u4fb5\u5bb3\u7b2c\u4e09\u4eba\u6b0a\u76ca\u4e4b\u865e\uff0c\u5c07\u4e00\u6982\u7531PR Newswire \u7f8e\u901a\u793e\u627f\u64d4\u6cd5\u5f8b\u53ca\u640d\u5bb3\u8ce0\u511f\u4e4b\u8cac\u4efb\uff0c\u8207\u65b0\u982d\u689dThehubnews\u7121\u95dc\u3002<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2023\u5e7412\u67086\u65e5 <\/p>\n","protected":false},"author":6,"featured_media":103600,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[36],"tags":[423],"class_list":["post-103599","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-life","tag-423","two-columns"],"_links":{"self":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts\/103599","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=103599"}],"version-history":[{"count":0,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/posts\/103599\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=\/wp\/v2\/media\/103600"}],"wp:attachment":[{"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=103599"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=103599"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/gothe.tw\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=103599"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}