{"id":102969,"date":"2023-12-04T08:49:00","date_gmt":"2023-12-04T00:49:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=102969"},"modified":"2023-12-04T08:49:00","modified_gmt":"2023-12-04T00:49:00","slug":"%e9%9b%b2%e9%a0%82%e6%96%b0%e8%80%80%e5%ae%a3%e5%b8%83%e4%b8%ad%e5%9c%8b%e5%9c%8b%e5%ae%b6%e8%97%a5%e5%93%81%e7%9b%a3%e7%9d%a3%e7%ae%a1%e7%90%86%e5%b1%80%e5%8f%97%e7%90%86zetomipzomib%ef%bc%88","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=102969","title":{"rendered":"\u96f2\u9802\u65b0\u8000\u5ba3\u5e03\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\u53d7\u7406Zetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\u7533\u8acb"},"content":{"rendered":"<div>\n<div>\n<p class=\"prntac\"><i>\u2014 <\/i><i>\u96f2\u9802\u65b0\u8000\u8a08\u5283\u8207\u5408\u4f5c\u4f19\u4f34<\/i><i>Kezar<\/i><i>\u5171\u540c\u63a8\u9032\u6b63\u5728\u958b\u5c55\u7684<\/i><i>zetomipzomib<\/i><i>\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u6cbb\u7642\u6d3b\u52d5\u6027\u72fc\u7621\u6027\u814e\u708e\u7684\u5168\u7403<\/i><i><span class=\"xn-money\">2b<\/span><\/i><i>\u671f<\/i><i>PALIZADE<\/i><i>\u7814\u7a76<\/i><i> \u2013 <\/i><\/p>\n<p class=\"prntac\"><i>\u2014 Zetomipzomib<\/i><i>\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u5728\u65e9\u524d\u7684<\/i><i>2<\/i><i>\u671f\u7814\u7a76\u4e2d\u7372\u5f97\u7a4d\u6975\u7d50\u679c\uff0c\u7b2c<\/i><i>25<\/i><i>\u5468\uff08\u6cbb\u7642\u7d50\u675f\uff09\u548c\u7b2c<\/i><i>37<\/i><i>\u5468\uff08\u5373\u505c\u85e5\u96a8\u8a2a\u7b2c<\/i><i>12<\/i><i>\u5468\uff09\u6642\uff0c\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u7e3d\u9ad4\u814e\u9ad2\u7de9\u89e3\u7387\uff08<\/i><i>ORR<\/i><i>\uff09\u5206\u5225\u70ba<\/i><i>64.7%<\/i><i>\u548c<\/i><i>88.2%<\/i><i>\uff0c\u5b8c\u5168\u814e\u9ad2\u7de9\u89e3\u7387\uff08<\/i><i>CRR<\/i><i>\uff09\u5206\u5225\u70ba<\/i><i>35.3%<\/i><i>\u548c<\/i><i>41.2%<\/i><i>\uff0c\u5c3f\u86cb\u767d\u808c\u9150\u6bd4\u503c\uff08<\/i><i>UPCR<\/i><i>\uff09\u5206\u5225\u8f03\u57fa\u7dda\u5e73\u5747\u4e0b\u964d<\/i><i>57.0%<\/i><i>\u548c<\/i><i>83.0%<\/i><i>\uff0c\u540c\u6642\u814e\u5c0f\u7403\u6ffe\u904e\u7387\u4f30\u8a08\u503c\uff08<\/i><i>eGFR<\/i><i>\uff09\u5728\u6cbb\u7642\u671f\u9593\u4fdd\u6301\u7a69\u5b9a<\/i>\u00a0<i>\u2013<\/i>\u00a0<\/p>\n<p class=\"prntac\"><i>\u2014<\/i><i>\u814e\u75c5\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u662f\u96f2\u9802\u65b0\u8000\u7684\u91cd\u9ede\u95dc\u6ce8\u9818\u57df\uff0c<\/i><i>zetomipzomib<\/i><i>\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u53ef\u958b\u767c\u7528\u65bc\u6cbb\u7642\u5305\u62ec\u72fc\u7621\u6027\u814e\u708e\u3001\u7cfb\u7d71\u6027\u7d05\u6591\u72fc\u7621\u5728\u5167\u7684\u4e00\u7cfb\u5217\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u6709\u671b\u9032\u4e00\u6b65\u52a0\u5f37\u516c\u53f8\u5728\u81ea\u514d\u75be\u75c5\u9818\u57df\u7684\u9818\u5148\u5730\u4f4d<\/i><i>\u2014<\/i><\/p>\n<p><span class=\"legendSpanClass\">\u4e0a\u6d77<\/span><span class=\"legendSpanClass\">2023\u5e7412\u67084\u65e5<\/span> \/\u7f8e\u901a\u793e\/ \u2014 \u96f2\u9802\u65b0\u8000\uff08HKEX 1952.HK\uff09\u662f\u4e00\u5bb6\u5c08\u6ce8\u65bc\u5275\u65b0\u85e5\u548c\u75ab\u82d7\u958b\u767c\u3001\u5236\u9020\u3001\u5546\u696d\u5316\u7684\u751f\u7269\u5236\u85e5\u516c\u53f8\uff0c\u4eca\u65e5\u5ba3\u5e03\u4e2d\u570b\u570b\u5bb6\u85e5\u54c1\u76e3\u7763\u7ba1\u7406\u5c40\uff08NMPA\uff09\u5df2\u53d7\u7406zetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u5728\u4e2d\u570b\u7684\u65b0\u85e5\u81e8\u5e8a\u8a66\u9a57\uff08IND\uff09\u7533\u8acb\u3002Zetomipzomib\u662f\u4e00\u6b3e\u65b0\u4e00\u985e\u9996\u5275\u3001\u9078\u64c7\u6027\u514d\u75ab\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\uff0c\u7528\u65bc\u6cbb\u7642\u5305\u62ec\u72fc\u7621\u6027\u814e\u708e\u3001\u7cfb\u7d71\u6027\u7d05\u6591\u72fc\u7621\u5728\u5167\u7684\u4e00\u7cfb\u5217\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u3002<\/p>\n<p>\u8a31\u591a\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\uff0c\u5305\u62ec\u72fc\u7621\u6027\u814e\u708e\u548c\u7cfb\u7d71\u6027\u7d05\u6591\u72fc\u7621\uff0c\u5728\u4e9e\u6d32\u7684\u767c\u75c5\u7387\u76f8\u6bd4\u5176\u4ed6\u5730\u5340\u66f4\u9ad8\u3002\u64da\u4f30\u8a08\uff0c\u50c5\u5728\u4e2d\u570b\u5c31\u6709100\u842c\u7cfb\u7d71\u6027\u7d05\u6591\u72fc\u7621\u60a3\u8005\uff0c 40%~60% \u7cfb\u7d71\u6027\u7d05\u6591\u72fc\u7621\u60a3\u8005\u7684\u75be\u75c5\u7d2f\u53ca\u814e\u9ad2\uff0c\u5373\u72fc\u7621\u6027\u814e\u708e\u3002\u72fc\u7621\u6027\u814e\u708e\u662f\u6700\u5e38\u898b\u7684\u7e7c\u767c\u6027\u514d\u75ab\u6027\u814e\u5c0f\u7403\u75be\u75c5\uff0c\u96a8\u8457\u75be\u75c5\u767c\u5c55\u53ef\u9010\u6f38\u5c0e\u81f4\u814e\u529f\u80fd\u8870\u7aed\uff0c\u662f\u7d42\u672b\u671f\u814e\u75c5\u7684\u5e38\u898b\u75c5\u56e0\u4e4b\u4e00\u3002\u5340\u5225\u65bc\u50b3\u7d71\u7684\u76f4\u63a5\u514d\u75ab\u6291\u5236\u5291\u4f5c\u7528\uff0czetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u53ef\u4ee5\u8abf\u7bc0\u5148\u5929\u514d\u75ab\u548c\u7372\u5f97\u6027\u514d\u75ab\u53cd\u61c9\uff0c\u5f9e\u800c\u964d\u4f4e\u708e\u75c7\u5c0d\u5668\u5b98\u9020\u6210\u7684\u640d\u50b7\uff0c\u9019\u4e00\u7279\u6027\u4f7f\u5176\u5177\u6709\u6cbb\u7642\u591a\u7a2e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u6f5b\u529b\uff0c\u4e14zetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u5c0d\u514d\u75ab\u86cb\u767d\u9176\u9ad4\u7684\u9078\u64c7\u6027\u6291\u5236\u53c8\u53ef\u907f\u514d\u96d9\u91cd\u9776\u5411\u86cb\u767d\u9176\u9ad4\u6291\u5236\u76f8\u95dc\u7684\u5168\u8eab\u526f\u4f5c\u7528\u3002<\/p>\n<p>\u96f2\u9802\u65b0\u8000\u8a08\u5283\u8207\u5408\u4f5c\u4f19\u4f34Kezar Life Sciences\u5171\u540c\u63a8\u9032PALIZADE\u7814\u7a76\uff0c\u9019\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u5b89\u6170\u5291\u5c0d\u71672b\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u5169\u7a2e\u5291\u91cf\u6c34\u5e73\u7684zetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u5728\u6d3b\u52d5\u6027\u72fc\u7621\u6027\u814e\u708e\u60a3\u8005\u4e2d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002<\/p>\n<p>\u96f2\u9802\u65b0\u8000\u9996\u5e2d\u57f7\u884c\u5b98\u7f85\u6c38\u6176\u8868\u793a\uff1a\u300cZetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u7684IND\u7533\u8acb\u9806\u5229\u53d7\u7406\u6a19\u5fd7\u8457\u6211\u5011\u671d\u8457\u5728\u4e2d\u570b\u958b\u5c55\u8a72\u5019\u9078\u85e5\u7269\u7684\u81e8\u5e8a\u7814\u7a76\u9081\u51fa\u4e86\u91cd\u8981\u4e00\u6b65\uff0c\u6211\u5011\u671f\u5f85\u5728\u72fc\u7621\u6027\u814e\u708e\u9ad8\u767c\u7684\u4e2d\u570b\u5165\u7d44\u60a3\u8005\uff0c\u6210\u70baPALIZADE\u5168\u7403\u7814\u7a76\u7684\u91cd\u8981\u7d44\u6210\u90e8\u5206\uff0c\u4e26\u5229\u7528\u516c\u53f8\u5728\u81e8\u5e8a\u958b\u767c\u548c\u6ce8\u518a\u4e0a\u5e02\u7b49\u65b9\u9762\u7684\u8c50\u5bcc\u7d93\u9a57\uff0c\u76e1\u5feb\u5c07\u9019\u4e00\u91cd\u8981\u7684\u5275\u65b0\u7642\u6cd5\u5e36\u7d66\u4e9e\u6d32\u60a3\u8005\u3002\u814e\u75c5\u548c\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u662f\u516c\u53f8\u7684\u91cd\u9ede\u6cbb\u7642\u9818\u57df\uff0c\u6191\u501fzetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u5728\u72fc\u7621\u6027\u814e\u708e\u548c\u5176\u4ed6\u81ea\u514d\u6027\u75be\u75c5\u9818\u57df\u7684\u6f5b\u529b\uff0c\u5c07\u9032\u4e00\u6b65\u978f\u56fa\u96f2\u9802\u65b0\u8000\u5728\u4e9e\u6d32\u7684\u9818\u5148\u5730\u4f4d\u3002\u300d<\/p>\n<p>Zetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u5728\u65e9\u524d\u76842\u671f\u81e8\u5e8a\u7814\u7a76\u4e2d\u7372\u5f97\u7a4d\u6975\u7d50\u679c\uff0c\u7b2c25\u5468\uff08\u6cbb\u7642\u7d50\u675f\uff09\u548c\u7b2c37\u5468\uff08\u5373\u505c\u85e5\u96a8\u8a2a\u7b2c12\u5468\uff09\u6642\uff0c\u5177\u6709\u81e8\u5e8a\u610f\u7fa9\u7684\u7e3d\u9ad4\u814e\u9ad2\u7de9\u89e3\u7387\uff08ORR\uff09\u5206\u5225\u70ba64.7%\u548c88.2%\uff0c\u5b8c\u5168\u814e\u9ad2\u7de9\u89e3\u7387\uff08CRR\uff09\u5206\u5225\u70ba35.3%\u548c41.2%\uff0c\u5c3f\u86cb\u767d\u808c\u9150\u6bd4\u503c\uff08UPCR\uff09\u5206\u5225\u8f03\u57fa\u7dda\u5e73\u5747\u4e0b\u964d57.0%\u548c83.0%\uff0c\u540c\u6642\u814e\u5c0f\u7403\u6ffe\u904e\u7387\u4f30\u8a08\u503c\uff08eGFR\uff09\u5728\u6cbb\u7642\u671f\u9593\u4fdd\u6301\u7a69\u5b9a\u3002\u7814\u7a76\u671f\u9593\uff0czetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u9084\u8868\u73fe\u51fa\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\uff0c\u4e14\u96a8\u8a2a\u671f\u5167\u672a\u767c\u73fe\u65b0\u7684\u5b89\u5168\u6027\u4fe1\u865f\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>Zetomipzomib <\/b><b>\uff08\u6fa4\u6258\u4f50\u7c73\uff09<\/b><\/p>\n<p>Zetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff0cKZR-616\uff09\u662f\u4e00\u6b3e\u65b0\u578b\u3001\u540c\u985e\u9996\u5275\u3001\u9078\u64c7\u6027\u514d\u75ab\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5291\uff0c\u5728\u591a\u7a2e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u4e2d\u5177\u6709\u5ee3\u6cdb\u7684\u6cbb\u7642\u6f5b\u529b\u3002\u81e8\u5e8a\u524d\u7814\u7a76\u8868\u660e\uff0c\u9078\u64c7\u6027\u514d\u75ab\u86cb\u767d\u9176\u9ad4\u6291\u5236\u5728\u591a\u7a2e\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u7684\u52d5\u7269\u6a21\u578b\u4e2d\u7522\u751f\u5ee3\u6cdb\u7684\u6297\u708e\u53cd\u61c9\uff0c\u540c\u6642\u907f\u514d\u514d\u75ab\u6291\u5236\u4f5c\u7528\u30021\u671f\u548c2\u671f\u81e8\u5e8a\u8a66\u9a57\u7684\u6578\u64da\u5145\u5206\u8868\u660ezetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u5728\u6cbb\u7642\u56b4\u91cd\u3001\u6162\u6027\u81ea\u8eab\u514d\u75ab\u6027\u75be\u75c5\u65b9\u9762\u5177\u6709\u826f\u597d\u7684\u5b89\u5168\u6027\u548c\u8010\u53d7\u6027\u7279\u5f81\u3002<\/p>\n<p><b>\u95dc\u65bc<\/b><b>PALIZADE<\/b><b>\u7814\u7a76<\/b><\/p>\n<p>PALIZADE\u662f\u4e00\u9805\u5168\u7403\u6027\u3001\u5b89\u6170\u5291\u5c0d\u7167\u3001\u96a8\u6a5f\u3001\u96d9\u76f22b\u671f\u81e8\u5e8a\u8a66\u9a57\uff0c\u65e8\u5728\u8a55\u4f30\u5169\u7a2e\u5291\u91cf\u6c34\u5e73\u7684zetomipzomib\uff08\u6fa4\u6258\u4f50\u7c73\uff09\u5728\u6d3b\u52d5\u6027\u72fc\u7621\u6027\u814e\u708e\u60a3\u8005\u4e2d\u7684\u7642\u6548\u548c\u5b89\u5168\u6027\u3002\u76ee\u6a19\u5165\u7d44\u4eba\u6578\u70ba279\u540d\u60a3\u8005\uff0c\u9019\u4e9b\u60a3\u8005\u5728\u6a19\u51c6\u80cc\u666f\u6cbb\u7642\u7684\u57fa\u790e\u4e0a\u88ab\u96a8\u6a5f\u5206\u914d\u63a5\u53d730 mg zetomipzomib\u300160 mg zetomipzomib\u6216\u5b89\u6170\u5291\uff0c\u76ae\u4e0b\u7d66\u85e5\uff0c\u6bcf\u54681\u6b21\uff0c\u6301\u7e8c52\u5468\u3002\u80cc\u666f\u6cbb\u7642\u53ef\u5305\u62ec\u6a19\u51c6\u8a98\u5c0e\u6cbb\u7642\uff08\u975e\u5f37\u5236\u8981\u6c42\uff09\u3002\u5728\u6700\u521d\u768416\u5468\u5167\uff0c\u5c07\u5f37\u5236\u5c07\u76ae\u8cea\u985e\u56fa\u9187\u9010\u6f38\u6e1b\u91cf\u81f35 mg\/d\u6216\u66f4\u5c11\u3002\u6cbb\u7642\u7d50\u675f\u8a55\u4f30\u5c07\u5728\u7b2c53\u5468\u9032\u884c\u3002\u4e3b\u8981\u7642\u6548\u7d42\u9ede\u662f\u7b2c37\u5468\u6642\u9054\u5230\u5b8c\u5168\u814e\u9ad2\u7de9\u89e3\uff08CRR\uff09\u7684\u60a3\u8005\u6bd4\u4f8b\uff0c\u5b8c\u5168\u814e\u9ad2\u7de9\u89e3\u5305\u62ec\u5728\u672a\u63a5\u53d7\u633d\u6551\u6216\u7981\u7528\u85e5\u7269\u7684\u60c5\u6cc1\u4e0b\uff0c\u5c3f\u86cb\u767d\u808c\u9150\u6bd4\u503c\uff08UPCR\uff09\u5c0f\u65bc\u6216\u7b49\u65bc0.5\u3002\u6709\u95dcPALIZADE\u7684\u66f4\u591a\u4fe1\u606f\uff0c\u8acb\u53c3\u898b<a href=\"https:\/\/www.clinicaltrials.gov\/study\/NCT05781750?spons=Kezar%20Life%20Sciences,%20Inc.&aggFilters=phase:2&rank=1\" target=\"_blank\" rel=\"nofollow 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href=\"http:\/\/www.everestmedicines.com\/\" target=\"_blank\" rel=\"nofollow 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