{"id":102210,"date":"2023-12-01T12:00:00","date_gmt":"2023-12-01T04:00:00","guid":{"rendered":"https:\/\/gothe.tw\/?p=102210"},"modified":"2023-12-01T12:00:00","modified_gmt":"2023-12-01T04:00:00","slug":"%e4%bf%a1%e9%81%94%e7%94%9f%e7%89%a9%e5%9c%a82023-esmo-asia%e5%a4%a7%e6%9c%83%e5%85%ac%e4%bd%88ibi351%ef%bc%88kras-g12c%e6%8a%91%e5%88%b6%e5%8a%91%ef%bc%89%e5%96%ae%e8%97%a5%e6%b2%bb%e7%99%82%e8%82%ba","status":"publish","type":"post","link":"https:\/\/gothe.tw\/?p=102210","title":{"rendered":"\u4fe1\u9054\u751f\u7269\u57282023 ESMO Asia\u5927\u6703\u516c\u4f48IBI351\uff08KRAS G12C\u6291\u5236\u5291\uff09\u55ae\u85e5\u6cbb\u7642\u80ba\u764c\u53ca\u7d50\u76f4\u8178\u764c\u7684\u5169\u9805\u81e8\u5e8a\u7814\u7a76\u6578\u64da\u66f4\u65b0"},"content":{"rendered":"<div>\n<div>\n<p>\u7f8e\u570b\u7f85\u514b\u7dad\u723e\u548c\u4e2d\u570b\u8607\u5dde2023\u5e7412\u67081\u65e5 \/\u7f8e\u901a\u793e\/ \u2014 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type=\"disc\">\n<li>IBI351\u986f\u793a\u51fa\u512a\u7570\u7684\u6297\u816b\u7624\u6d3b\u6027\u3002\u7368\u7acb\u5f71\u50cf\u5b78\u8a55\u5be9\u59d4\u54e1\u6703\uff08IRRC\uff09\u8a55\u4f30\u7684\u78ba\u8a8d\u7684<b>\u5ba2\u89c0\u7de9\u89e3\u7387\uff08<\/b><b>ORR\uff09\u905446.6% (95%CI: 37.2-56.0)\uff0c\u9054\u5230\u4e86\u9810\u8a2d\u7684\u4e3b\u8981\u7d42\u9ede\uff1b\u75be\u75c5\u63a7\u5236\u7387\uff08DCR\uff09\u905490.5% (95%CI: 83.7, 95.2)\u3002<\/b>\u4e2d\u4f4d\u7de9\u89e3\u6301\u7e8c\u6642\u9593\uff08DoR\uff09\u70ba8.3\u500b\u6708\uff0c\u51fa\u73fe\u816b\u7624\u7de9\u89e3\u7684\u53d7\u8a66\u8005\uff0c53.7%\uff0829\/54\uff09\u4ecd\u5728\u6cbb\u7642\u4e2d\u3002<b>\u4e2d\u4f4d\u7121\u9032\u5c55\u751f\u5b58\u671f\uff08<\/b><b>PFS\uff098.3\u500b\u6708\uff0895%CI: 5.6-10.4\uff09\uff0c\u4e2d\u4f4d\u751f\u5b58\u671f\uff08OS\uff09\u5c1a\u672a\u9054\u5230\u3002<\/b><\/li>\n<li>IBI351\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\u3002\u622a\u81f3\u6578\u64da\u5206\u6790\u65e5\uff0c\u5171\u670990.5%\uff08105\/116\uff09\u7684\u53d7\u8a66\u8005\u767c\u751f\u6cbb\u7642\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAE\uff09\uff0c\u5927\u90e8\u5206\u70ba1-2\u7d1a\uff0c\u6700\u5e38\u898b\u7684TRAEs\u70ba\u8ca7\u8840\u3001\u4e19\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u5347\u9ad8\u3001\u5929\u9580\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u5347\u9ad8\u3001\u4e4f\u529b\u548c\u86cb\u767d\u5c3f\u300240.5%\u7684\u53d7\u8a66\u8005\u767c\u751f3\u7d1a\u53ca\u4ee5\u4e0aTRAEs\u3002<\/li>\n<\/ul>\n<p><b>\u672c\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u5ee3\u6771\u7701\u4eba\u6c11\u91ab\u9662\u5433\u4e00\u9f8d\u6559\u6388<\/b>\u8868\u793a<b>\uff1a<\/b>\u300cKRAS\u4f5c\u70ba\u6700\u65e9\u88ab\u767c\u73fe\u7684\u764c\u57fa\u56e0\u4e4b\u4e00\uff0c\u66fe\u7d93\u7684\u300e\u4e0d\u53ef\u6210\u85e5\u300f\u9776\u9ede\u5df2\u6210\u70ba\u76ee\u524d\u7814\u767c\u7684\u71b1\u9580\u65b9\u5411\uff0c\u96d6\u6d77\u5916\u5df2\u6709FDA\u7372\u6279\u7684KRAS G12C\u9776\u5411\u85e5\u7269\uff0c\u4e2d\u570b\u5c1a\u7121\u76f8\u95dc\u85e5\u7269\u7372\u6279\u4e0a\u5e02\u3002IBI351 \u662f\u4e2d\u570b\u9996\u500bNDA\u7372\u53d7\u7406\u7684KRAS G12C\u6291\u5236\u5291\uff0c\u4f5c\u70ba\u4e00\u7a2e\u7279\u7570\u6027\u5171\u50f9\u4e0d\u53ef\u9006\u7684KRAS G12C\u6291\u5236\u5291\uff0c\u55ae\u85e5\u5728\u81f3\u5c11\u4e00\u7dda\u7cfb\u7d71\u6cbb\u7642\u5931\u6557\u7684\u651c\u5e36KRAS G12C \u7a81\u8b8a\u665a\u671f\u80ba\u764c\u7684\u95dc\u9375\u8a3b\u518a\u7814\u7a76\u4e2d\u5c55\u793a\u51fa\u4e86\u512a\u7570\u7684\u7642\u6548\u548c\u826f\u597d\u7684\u5b89\u5168\u6027\u3002\u6211\u5011\u671f\u5f85\u8a72\u85e5\u7269\u65e9\u65e5\u7372\u6279\uff0c\u8b93\u66f4\u591aKRAS G12C \u7a81\u8b8a\u7684\u665a\u671f\u5f8c\u7dda\u80ba\u764c\u60a3\u8005\u7372\u76ca\u3002\u300d<\/p>\n<p><b>IBI351\u55ae\u85e5\u6cbb\u7642\u5728\u651c\u5e36KRAS G12C\u7a81\u8b8a\u7684\u665a\u671f\u7d50\u76f4\u8178\u764c\uff08CRC\uff09\u60a3\u8005\u4e2d\u7684\u5b89\u5168\u6027\u548c\u6709\u6548\u6027\uff1a\u4f86\u81ea\u5169\u9805\u81e8\u5e8aI\u671f\u7814\u7a76\u7684\u532f\u7e3d\u5206\u6790\u66f4\u65b0<\/b><\/p>\n<p>\u6458\u8981\u7de8\u865f\uff1a106P<\/p>\n<p>IBI351\uff08GFH925\uff09\u662f\u4e00\u7a2e\u7279\u7570\u6027\u5171\u50f9\u4e0d\u53ef\u9006\u7684KRAS G12C \u6291\u5236\u5291\u3002\u672c\u6b21\u5831\u9053\u7684\u6578\u64da\u662f\u57fa\u65bc\u5169\u9805\u6b63\u5728\u9032\u884c\u7684\u81e8\u5e8a\u7814\u7a76\u7684\u532f\u7e3d\u7d50\u679c\u7684\u6578\u64da\u66f4\u65b0\uff08NCT05005234, NCT05497336\uff09\u3002<\/p>\n<p>\u622a\u81f32023\u5e74\uff16\u67081\uff13\u65e5\uff0c\u5171\u670956\u4f8b\u665a\u671fCRC\u53d7\u8a66\u8005\u7d0d\u5165\u5206\u6790\uff08\u5176\u4e2d700mg QD\u5291\u91cf\u7d443\u4f8b\uff0c 450mg BID\u5291\u91cf\u7d444\u4f8b\uff0c600mg BID\u5291\u91cf\u7d4448\u4f8b\uff0c750mg BID\u5291\u91cf\u7d441\u4f8b\uff09\u3002\u7814\u7a76\u7d50\u679c\u986f\u793a\uff1a<\/p>\n<ul type=\"disc\">\n<li><b>600mg BID\u5291\u91cf\u7d44\u4e2d\u5171\u670948\u4f8b\u53d7\u8a66\u8005\u63a5\u53d7\u4e86\u81f3\u5c11\u4e00\u6b21\u816b\u7624\u8a55\u4f30\uff0c\u78ba\u8a8d\u7684ORR\u70ba45.8%\uff0cDCR\u70ba89.6%\u3002<\/b>\u4e2d\u4f4dDoR\u5c1a\u672a\u9054\u5230\uff0c6\u500b\u6708DoR\u738765.5%\u3002\u4e2d\u4f4dPFS 7.6\u500b\u6708\u3002\u4e2d\u4f4dOS\u5c1a\u672a\u9054\u5230\uff0c6\u500b\u6708OS\u738791.1%\u3002<\/li>\n<li><b>600mg BID\u5291\u91cf\u7d44\u4e2d\u5171\u670927\u4f8b\u53d7\u8a66\u8005\u65e2\u5f80\u63a5\u53d7\u4e862\u7dda\u53ca\u4ee5\u4e0a\u7684\u7cfb\u7d71\u6027\u6cbb\u7642\u3002\u78ba\u8a8d\u7684ORR\u70ba63.0%\uff0cDCR\u70ba88.9%<\/b>\u3002<\/li>\n<li>\u5b89\u5168\u6027\u65b9\u9762\uff0c\u622a\u81f3\u6578\u64da\u5206\u6790\u65e5\uff0c\u7e3d\u9ad4\u8010\u53d7\u6027\u826f\u597d\u3002\u5171\u670994.6%\u7684\u53d7\u8a66\u8005\u767c\u751f\u85e5\u7269\u76f8\u95dc\u4e0d\u826f\u4e8b\u4ef6\uff08TRAEs\uff09\uff0c\u5927\u90e8\u5206\u70ba1-2\u7d1a\uff0c\u6700\u5e38\u898b\u7684TRAE\u70ba\u8ca7\u8840\u3001\u767d\u7d30\u80de\u8a08\u6578\u964d\u4f4e\u3001\u8840\u81bd\u7d05\u7d20\u5347\u9ad8\u3001\u7619\u7662\u3001\u4e2d\u6027\u7c92\u7d30\u80de\u8a08\u6578\u964d\u4f4e\u3001\u5929\u9580\u51ac\u6c28\u9178\u6c28\u57fa\u8f49\u79fb\u9176\u5347\u9ad8\u548c\u03b3-\u8c37\u6c28\u9170\u8f49\u80bd\u9176\u5347\u9ad8\u3002\u7d0423.2%\u7684\u53d7\u8a66\u8005\u767c\u751f3\u7d1aTRAEs\uff0c\u71214\u7d1a\u548c5\u7d1a\u7684TRAEs\u4ee5\u53ca\u5c0e\u81f4\u6cbb\u7642\u7d42\u6b62\u7684TRAEs\u767c\u751f\u3002<\/li>\n<\/ul>\n<p><b>\u672c\u7814\u7a76\u4e3b\u8981\u7814\u7a76\u8005\uff0c\u6d59\u6c5f\u5927\u5b78\u91ab\u5b78\u9662\u9644\u5c6c\u7b2c\u4e8c\u91ab\u9662\u8881\u745b\u6559\u6388<\/b>\u8868\u793a\uff1a\u300cKRAS G12C\u7a81\u8b8a\u7684\u665a\u671f\u7d50\u76f4\u8178\u764c\u60a3\u8005\u9810\u5f8c\u5dee\uff0c\u751f\u5b58\u671f\u77ed\uff0c\u73fe\u6709\u6cbb\u7642\u624b\u6bb5\u6709\u9650\u7642\u6548\u6b20\u4f73\uff0c\u76ee\u524d\u5c1a\u7121\u91dd\u5c0d\u8a72\u9776\u9ede\u8a72\u9069\u61c9\u75c7\u7684\u85e5\u7269\u7372\u6279\uff0c\u81e8\u5e8a\u5b58\u5728\u8feb\u5207\u9700\u6c42\u3002IBI351\u662f\u4e00\u7a2e\u7279\u7570\u6027\u5171\u50f9\u4e0d\u53ef\u9006\u7684KRAS G12C\u6291\u5236\u5291\u3002IBI351\u55ae\u85e5\u5728KRAS G12C 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href=\"https:\/\/www.innoventbio.com\/\" target=\"_blank\" rel=\"nofollow noopener\">www.innoventbio.com<\/a>\u6216\u516c\u53f8\u9818\u82f1\u8cec\u865f<a href=\"https:\/\/www.linkedin.com\/company\/innovent-biologics\/\" target=\"_blank\" rel=\"nofollow 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